RESUMEN
Wade's histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior treatment. Clinically, HL resembles keloid or dermatofibroma. Furthermore, HL is rare in children and is difficult to diagnose even by experts. This report describes a case of HL in a 14-year-old Brazilian boy, who presented with multiple nodular and tumor-like lesions, simulating keloids. He had not undergone prior treatment with anti-leprosy drugs, which accentuates the relevance of this case report.
Asunto(s)
Lepra Multibacilar/diagnóstico , Adolescente , Diagnóstico Diferencial , Humanos , Lepra Multibacilar/patología , Masculino , Piel/patologíaRESUMEN
Abstract Wade's histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior treatment. Clinically, HL resembles keloid or dermatofibroma. Furthermore, HL is rare in children and is difficult to diagnose even by experts. This report describes a case of HL in a 14-year-old Brazilian boy, who presented with multiple nodular and tumor-like lesions, simulating keloids. He had not undergone prior treatment with anti-leprosy drugs, which accentuates the relevance of this case report.
Asunto(s)
Humanos , Lepra Multibacilar/patología , Piel/patología , Diagnóstico Diferencial , Lepra Multibacilar/diagnósticoAsunto(s)
Enfermedades Desmielinizantes/inducido químicamente , Fármacos Dermatológicos/efectos adversos , Infliximab/efectos adversos , Trastornos Motores/inducido químicamente , Psoriasis/tratamiento farmacológico , Trastornos de la Sensación/inducido químicamente , Adulto , Humanos , Masculino , Síndrome , Factor de Necrosis Tumoral alfa/antagonistas & inhibidoresAsunto(s)
Humanos , Masculino , Adulto , Psoriasis/tratamiento farmacológico , Enfermedades Desmielinizantes/inducido químicamente , Trastornos de la Sensación/inducido químicamente , Fármacos Dermatológicos/efectos adversos , Infliximab/efectos adversos , Trastornos Motores/inducido químicamente , Síndrome , Linfotoxina-alfa/antagonistas & inhibidoresRESUMEN
Abstract We report an unprecedented case of ectopic thymoma in a young adult. A 33-year-old male presented with a 10-day history of non-productive cough and fever. Investigation revealed mediastinal widening without pulmonary involvement. Computed tomography showed a large mass-14.8 × 10.8 × 8.4 cm-in the mid-posterior mediastinum, and a biopsy obtained by video-assisted thoracoscopy indicated that the mass was a tumor. Immunohistochemistry showed combined thymoma type AB1. Because of the considerable proportions of the tumor and its close proximity to major structures, the patient was treated with chemotherapy.
Resumo Apresentamos caso inédito de volumoso timoma ectópico em adulto jovem. Homem de 33 anos de idade, encaminhado com tosse seca e febre diária havia 10 dias. Durante investigação observou-se alargamento mediastinal sem comprometimento pulmonar. Um tumor mediastinal medioposterior, medindo 14,8 × 10,8 × 8,4 cm, foi diagnosticado após tomografia computadorizada e biópsia videotoracoscópica. A imuno-histoquímica revelou timoma misto AB1. Devido à íntima relação com estruturas nobres e grandes proporções, optou-se pela quimioterapia.
