RESUMEN
(1) Background: Vitiligo is characterized by white patches on the skin caused by loss of melanocyte activity or the absence of these cells. The available treatments minimize the symptoms by retarding the process of skin depigmentation or re-pigmenting the affected regions. New studies are required for a better comprehension of the mechanisms that trigger the disease and for the development of more efficient treatments. Studies have suggested an autoimmune feature for vitiligo, based on the occurrence of other autoimmune diseases in vitiligo patients and their relatives, and on the involvement of genes related to the immune response. (2) Methods: We evaluated, by massive parallel sequencing, polymorphisms of the HLA-G gene in vitiligo patients and control samples, to verify if variants of this gene could influence the susceptibility to vitiligo. (3) Results: We detected an association with non-segmental vitiligo regarding the haplotype Distal-010101a/G*01:01:01:01/UTR-1, adjusting for population stratification by using ancestry-informative markers (AIMs). (4) Conclusions: It remains unclear whether the HLA-G variants associated with vitiligo were detected because of the high linkage disequilibrium (LD) with HLA-A*02, or if the HLA-A variants previously reported as associated with vitiligo were detected because of the high LD with HLA-G*01:01:01:01/UTR-1, or if both genes jointly contribute to vitiligo susceptibility.
Asunto(s)
Antígenos HLA-G/genética , Polimorfismo Genético , Vitíligo/genética , Adolescente , Adulto , Anciano , Brasil , Femenino , Predisposición Genética a la Enfermedad/genética , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
Dentistas e técnicos estäo constantemente à procura dos melhores resultados com restauraçöes em porcelana, quanto a estética, funçäo e adaptaçäo marginal. O IPS Empress II (Ivoclar-Vivadent) é um dos novos sistemas de cerâmica encontrados no mercado que podem ser usados para restauraçöes livres de metal. Os objetivos deste artigo säo apresentar um caso clínico de restauraçäo posterior com o IPS Empress II e discutir aspectos técnicos da preparaçäo do dente e das características do material