Sleep in Persons Living with Alzheimer's Disease and Related Dementias.

Over a typical lifespan, the amount of time people spend each day sleeping decreases. Sleep patterns also change as people age. Sleep disorders are common among persons of all ages, and older adults are particularly vulnerable. Development of age-related neurodegenerative diseases, such as Alzheimer's disease and related dementias, is associated with pronounced sleep disruption. This article provides evidence-based guidelines for diagnosis and clinical management of sleep disorders that occur during the course of treatment of Alzheimer's disease and related dementias. The article presents novel interventions and future directions for clinical practice and sleep research, and addresses diversity and inclusivity.

Eficacia de la asociación de lacosamida en neuralgia del trigémino / Effectiveness of the association of lacosamide in trigeminal neuralgia

La neuralgia del trigémino es un motivo de consulta frecuente en neurología, es sumamente complejo e incapacitante. Su abordaje, además de un adecuado enfoque etiológico, precisa de un tratamiento sintomático eficaz. Presentamos dos pacientes con neuralgia del trigémino y buena respuesta al tratamiento con lacosamida. La lacosamida es un fármaco que muestra ser una alternativa segura y eficaz en el tratamiento del dolor neuropático

Trigeminal neuralgia is a frequent reason for consultation in neurology, it is highly complex and incapacitating. Its approach, in addition to an adequate etiological focusing, requires effective symptomatic treatment. We present two patients with trigeminal neuralgia and good response to treatment with lacosamide. Lacosamide is a drug that appears to be a safe and effective alternative in the treatment of neuropathic pain

A geometric morphometric approach to the analysis of skull shape in Triassic dicynodonts (Therapsida, Anomodontia) from South America.

Dicynodont therapsids were a major component of the Permo-Triassic terrestrial ecosystems across Pangea and have been regarded as specialized herbivores. In South America, the group was represented by several taxa of the clade Kannemeyeriiformes spanning from the Middle to the Late Triassic. In order to evaluate if cranial differences among taxa are potentially related to differences in feeding function, we performed a geometric morphometric analysis on 28 South American dicynodont crania. We digitized 19 cranial landmarks and conducted generalized Procrustes analysis, principal component analysis (PCA), principal component analysis between groups (bg-PCA), and a branch weighted squared-change parsimony approach. Phylogenetic inertia was not a significant driver of cranial shape evolution in the group, whereas PCA and bg-PCA support that major morphological shape differences are concentrated in the preorbital region (relative length of the snout and width of the caniniform process), in the position of quadrate condyle in relation to the caniniform process, and in the increase in the intertemporal surface area. In this context, tusked Dinodontosaurus, "Kannemeyeria," and Vinceria have relatively smaller adductor attachment areas and input moment arm than younger taxa lacking tusks, such as Ischigualastia, Stahleckeria, and Jachaleria. Differences in cranial morphology in later dicynodonts reflect modifications in feeding mechanics, probably due to changes in food resources (vegetation) in their habitats toward the end of the Triassic.