RESUMEN
A previously healthy 70-year-old woman presented with a 5-month history of an asymptomatic keratotic, papulonodular plaque on her right forearm. The lesion started as a follicular papule followed by progressive peripheral proliferation. No record of trauma, contact with any chemicals, use of immunosuppressive drugs, or history of neoplasm was noted. Clinical examination showed an arciform plaque of 10×5 cm, with infiltrated raised borders and central atrophy (Figure 1). Drops of yellowish material exuded from the coalescent nodules constituting an elevated and indurate border. Results from physical and laboratory examinations revealed no internal organ malignancy. The remainder of the physical examination (x-ray of the forearm and serologies for HIV, hepatitis, and syphilis) was normal.
Asunto(s)
Acitretina/uso terapéutico , Queratoacantoma/tratamiento farmacológico , Queratoacantoma/patología , Queratolíticos/uso terapéutico , Administración Oral , Anciano , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Antebrazo , Humanos , Queratoacantoma/diagnóstico , Enfermedades de la Piel/tratamiento farmacológico , Enfermedades de la Piel/patología , Resultado del TratamientoRESUMEN
A 45-year-old obese woman diagnosed with morphea on her leg, presented with a 7-year history of cutaneous depressions on her thigh, chest, and back. She recalled that the lesions followed a three-phase course: edema, hardening, and atrophy. Clinical examination revealed a cutaneous indurated depression localized to the thigh, chest, and the back (Figure 1).
Asunto(s)
Obesidad/complicaciones , Paniculitis/complicaciones , Psoriasis/complicaciones , Esclerodermia Localizada/complicaciones , Insuficiencia Venosa/complicaciones , Femenino , Humanos , Persona de Mediana Edad , Paniculitis/patologíaRESUMEN
[This corrects the article DOI: 10.1016/j.ijpam.2014.11.004.].
Asunto(s)
Antiprotozoarios/administración & dosificación , Leishmaniasis Mucocutánea/tratamiento farmacológico , Meglumina/administración & dosificación , Compuestos Organometálicos/administración & dosificación , Adolescente , Adulto , Humanos , Inyecciones Intralesiones , Leishmaniasis Mucocutánea/diagnóstico , Labio , Masculino , Antimoniato de Meglumina , Resultado del TratamientoRESUMEN
Erythema nodosum (EN) in association with kerion celsi is a rare condition in children, with only 11 cases having been reported in the English literature. We describe a new case in a 7-year-old boy in whom the disorder had begun 2 months before. He had many inflamed, boggy, suppurative nodules over the left occipitoparietal area of the scalp and, 2 weeks later, developed multiple painful, erythematous subcutaneous nodules of the shins, thighs, and upper limbs. EN was confirmed by histologic examination. Our review of the literature of all cases of EN during kerion showed that it usually occurs at or slightly after the height of infection or after drug introduction. Trichophyton mentagrophytes was involved in the majority of cases, and improvement of EN usually occurs with griseofulvin.
Asunto(s)
Eritema Nudoso/microbiología , Tiña del Cuero Cabelludo/diagnóstico , Tiña del Cuero Cabelludo/microbiología , Trichophyton , Antifúngicos/uso terapéutico , Niño , Eritema Nudoso/tratamiento farmacológico , Humanos , Masculino , Tiña del Cuero Cabelludo/tratamiento farmacológicoRESUMEN
BACKGROUND: Autoimmune bullous dermatoses (ABD) are a rare but significant group of cutaneous disorders posing great diagnostic and therapeutic challenges to the treating dermatologist. Few surveys have been carried out to describe the whole spectrum of ABD in a region. OBJECTIVE: To determine the clinicoepidemiological features of various ABD. METHODS: We retrospectively recruited all ABD cases seen during an 11-year period (1997-2007). RESULTS: One hundred and seventy-four patients were involved (16.3 cases/year). Pemphigus was observed to be the most common ABD (53%), with the majority being pemphigus vulgaris (61%) vs. 36% of pemphigus foliaceus (Tunisian pemphigus). DISCUSSION: Most epidemiological surveys have focused on a single or just one group of ABD. In our series, pemphigus foliaceus was relatively more prevalent than in occidental data. The frequencies of subepidermal immunobullous dermatoses in our study were in agreement with those in the literature.
Asunto(s)
Enfermedades Autoinmunes/epidemiología , Enfermedades Autoinmunes/patología , Enfermedades Cutáneas Vesiculoampollosas/epidemiología , Enfermedades Cutáneas Vesiculoampollosas/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Recolección de Datos , Femenino , Humanos , Incidencia , Lactante , Masculino , Persona de Mediana Edad , Pacientes Ambulatorios/estadística & datos numéricos , Estudios Retrospectivos , Túnez/epidemiología , Adulto JovenAsunto(s)
Artropatías/diagnóstico , Queratodermia Palmoplantar/diagnóstico , Osteoartropatía Hipertrófica Secundaria/diagnóstico , Dermatoglifia , Articulaciones de la Mano/patología , Humanos , Artropatías/patología , Queratodermia Palmoplantar/patología , Masculino , Persona de Mediana Edad , Osteoartropatía Hipertrófica Secundaria/patología , Fumar/efectos adversosRESUMEN
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with unknown etiology. PG associated with infectious disease is very unsual. We report a singular case of PG with lymph nodes tuberculosis disease.
RESUMEN
Hyperimmunoglobulin E recurrent infection syndrome (HIES) is characterized by recurrent skin and lung infections, eczema, elevated serum immunoglobulin E (IgE) levels (>2000 IU/mL), various connective tissue, skeletal, and vascular abnormalities.(1) We describe herein two brothers with HIES and documented the complications and management of such involvement.
RESUMEN
Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein-Barr Virus (EBV) at some extracutaneous sites is well documented. In contrast, the presence of EBV in LELCs has never been shown in either Caucasians or Asian patients. We present the first case of LELCs in a Tunisian patient, a 78-year-old woman who presented with a nodule of the right cheek of 2 months' duration. The patient underwent surgical excision and there was no evidence of local recurrence 6 months later. Histologically, the entire dermis was occupied by lobules composed of atypical epithelial cells surrounded by a dense lymphoplasmacytic infiltrate. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. In situ hybridization investigations for the presence of EBV-encoded RNA showed negative results. Our findings suggest that LELCs is not related to EBV among North African patients.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Cutáneas/patología , Anciano , Biomarcadores de Tumor/análisis , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/cirugía , Diagnóstico Diferencial , Supervivencia sin Enfermedad , Infecciones por Virus de Epstein-Barr/diagnóstico , Femenino , Humanos , Queratinas/análisis , Mucina-1/análisis , Neoplasias Cutáneas/química , Neoplasias Cutáneas/cirugíaRESUMEN
Pemphigus is a severe, autoimmune, blistering disorder with a high incidence among young women in rural Tunisia. The authors investigated explanatory environmental factors. A multicenter case-control study was conducted prospectively from 1992 to 1996 in Tunisia. Sixty-eight incident female cases of pemphigus and 166 controls matched on age, hospital, and geographic area were included. Data collected concerned socioeconomic status, medical history, drug intakes, lifestyle, and environment. Several factors were significantly associated with pemphigus in multivariate logistic regression analyses: traditional cosmetics (odds ratio (OR) = 4.0, 95% confidence interval (CI): 1.1, 14.8); Turkish baths (OR = 3.2, 95% CI: 1.4, 7.3); cutting up raw poultry (OR = 5.1, 95% CI: 1.3, 19.4); contact with ruminants (OR = 2.7, 95% CI: 1.3, 5.8); and wasp, bee, and spider stings (OR = 3.1, 95% CI: 1.5, 6.4). A dose-dependent relation was observed for traditional cosmetics. All risks except insect bites were higher when analysis was restricted to younger women, the demographic group with higher incidence. The strength of the associations, the dose-dependent relation for traditional cosmetics, and the increase of risk estimates for younger women support a causal relation. Traditional cosmetics widely used by Tunisian women could play a major role in excess of cases of pemphigus.