RESUMEN
A glue, based on dynamic covalent chemistry, with a strong adhesion (2.38â kg cm-2 ), water resistance and carbohydrate responsive reversibility is presented. Using surface initiated atom transfer radical polymerization (SI-ATRP), glass and silicon surfaces were coated with copolymers functionalized with phenylboronic acids and catechols. In combination with microcontact printing (µCP) these polymer brushes give access to a carbohydrate responsive "supramolecular Velcro".
RESUMEN
The ligation of gold(I) metalloamphiphiles with biomolecules is reported, using water-soluble AuI -N-alkynyl substituted maleimide complexes. For this purpose, two different polar ligands were applied: 1) a neutral, dendritic tetraethylene glycol-functionalized phosphane and 2) a charged, sulfonated N-heterocyclic carbene (NHC). The retro Diels-Alder reaction of a furan-protected maleimide gold(I) complex, followed by cycloaddition with a diene-functionalized biotin under mild conditions leads to a novel gold(I) metalloamphiphile. The strong streptavidin-biotin binding affinity in buffered aqueous solution of the resulting biotin alkynyl gold(I) phosphane conjugate remains intact. The cytotoxicity of the biotinylated gold(I) complex against a T47D human breast cancer cell line is higher than for cisplatin.
