RESUMEN
The systematic decline of rural areas in the process of rapid urbanization has become a global trend, creating greater challenges for sustainable rural development. As the spatial projection of socio-economic development and living environment in rural areas, the continuous tracking of rural settlements (RUS) is crucial to quantify the imbalance of rural development. However, consistent information on RUS is highly needed but is quite deficient in current research. In this study, a cost-effective mapping model was proposed to produce an annual RUS dataset in the rapid urbanization region of Beijing-Tianjin-Hebei (BTH) in North China during 1990-2020, and the temporal-spatial regularity of RUS changes was further analyzed. The location-based and the area-based comparison verified the effectiveness of our model, with a mean overall accuracy of 85% and a mean correlation value of 0.88, respectively. The total area of RUS in the BTH region increased by 2561 km2 from 1990 to 2020, while the average size of RUS remained stable after 2005. The annual change trends in RUS appeared with increasing and decreasing accounting for 76.33% and 23.67%, respectively. The centroids of RUS in Tianjin and Hebei have moved closer to Beijing, while those in Beijing have moved away from the former. Notably, we have identified 56.3% counties in the BTH region belong to the "Convex-I" change type in RUS. In general, our work can help to consistently quantify the spatiotemporal patterns of RUS in a cost-effective way, providing more explicit spatial information and continuous temporal information for rural residential land management.
RESUMEN
Seawater drowning-induced acute lung injury (ALI) is a serious clinical condition characterized by increased alveolar-capillary permeability, excessive inflammatory responses, and refractory hypoxemia. However, current therapeutic options are largely supportive; thus, it is of great interest to search for alternative agents to treat seawater aspiration-induced ALI. Erythropoietin (EPO) is a multifunctional agent with antiinflammatory, antioxidative, and antiapoptotic properties. However, the effects of EPO on seawater aspiration-induced ALI remain unclear. In the present study, male rats were randomly assigned to the naive group, normal saline group, seawater group, or seawater + EPO group. EPO was administered intraperitoneally at 48 and 24 h before seawater aspiration. Arterial blood gas analysis was performed with a gas analyzer at baseline, 30 min, 1 h, 4 h, and 24 h after seawater aspiration, respectively. Histological scores, computed tomography scan, nuclear factor kappa B p65, inducible nitric oxide synthase, caspase-3, tumor necrosis factor-alpha, interleukin (IL)-1ß, IL-6, IL-10, wet-to-dry weight ratio, myeloperoxidase activity, malondialdehyde, and superoxide dismutase in the lung were determined 30 min after seawater aspiration. Our results showed that EPO pretreatment alleviated seawater aspiration-induced ALI, as indicated by increased arterial partial oxygen tension and decreased lung histological scores. Furthermore, EPO pretreatment attenuated seawater aspiration-induced increase in the expressions of pulmonary nuclear factor kappa B p65, inducible nitric oxide synthase, caspase-3, tumor necrosis factor-alpha, IL-1ß, myeloperoxidase activity, and malondialdehyde when compared with the seawater group. Collectively, our study suggested that EPO pretreatment attenuates seawater aspiration-induced ALI by down-regulation of pulmonary pro-inflammatory cytokines, oxidative stress, and apoptosis.
