RESUMEN
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
Asunto(s)
Compuestos Policíclicos/síntesis química , Bibliotecas de Moléculas Pequeñas/síntesis química , Sulfóxidos/síntesis química , Compuestos Bicíclicos Heterocíclicos con Puentes/síntesis química , Reacción de Cicloadición , Descubrimiento de Drogas , Estructura Molecular , Pirazoles/síntesis química , Pirazoles/química , Compuestos de Espiro/síntesis química , EstereoisomerismoRESUMEN
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.