1.
J Antibiot (Tokyo)
; 73(6): 365-371, 2020 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32139881
RESUMEN
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.
Asunto(s)
Antimaláricos/farmacología , Ácidos Hidroxámicos/farmacología , Hypocreales/metabolismo , Plasmodium falciparum/efectos de los fármacos , Antimaláricos/administración & dosificación , Antimaláricos/aislamiento & purificación , Cloroquina/farmacología , Resistencia a Medicamentos , Ácidos Hidroxámicos/administración & dosificación , Ácidos Hidroxámicos/aislamiento & purificación , Concentración 50 Inhibidora , Japón
2.
J Antibiot (Tokyo)
; 71(7): 682-684, 2018 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29563600
RESUMEN
A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-L-phenylalanyl-L-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.
