Computational analysis of radon progeny deposition patterns in the human respiratory system.

In the last year, the use of computational fluid dynamics (CFD) techniques has gained prominence as a powerful tool for modeling biological phenomena and influencing the design of biomedical devices. In this study, we utilized a computational fluid dynamics (CFD) model to simulate airflow and the deposition of aerosol particles within the human respiratory tract. To achieve this, we meticulously constructed a 3D model of the human tracheobronchial airways using SolidWorks software. Our computational analyses encompassed a range of breathing conditions, ranging from 15 to 60 (L/min). Through the application of discrete phase modeling (DPM), we investigate the behavior of two-phase flow dynamics. Our focus lies in the examination of aerosol particles, with diameters ranging from 1 to 10 (µm), in order to evaluate the influence of aerosol particle size on deposition rates. Our findings encompass velocity contour maps, deposition rates of aerosol particles, and insights into the process of aerosol particle entrapment at various locations within the respiratory tract. Our study reveals a direct correlation between higher inhalation rates and larger aerosol particle sizes, resulting in increased deposition rates. Additionally, we observe a heightened deposition of aerosol-particles at bronchi region. These computational results hold significant value in estimating the distribution of doses resulting from radon progeny exposure in distinct anatomical regions of the respiratory tract.

A new fast algorithm to achieve the dose uniformity around high dose rate brachytherapy stepping source using Tikhonov regularization.

The dose optimization algorithm based on anatomical points is developed to produce rapidly uniform doses over target distances generated on the target volume edges in high-dose-rate (HDR) brachytherapy stepping source application for a treatment length of 6 cm. Monte Carlo modeling of the 60Co HDR brachytherapy source and the surrounding medium were performed using PHITS code. The source dwell times were optimized using Tikhonov regularization in order to obtain uniform dose distribution at the anatomical points located at predefined target distances. The computed dose rates at distances from 0.25 up to 20 cm away from the source were first verified with the literature data sets. Then, the simulation results of the optimization process were compared to the calculations of commercial treatment planning system (TPS) SagiPlan. As a result, the dose uniformity was observed in the isodose curves at the target distances of 10 and 15 mm of the treatment length and the prescribed dose achieved the anatomical points uniformly. The algorithm developed in the present study can be applied for achieving the dose uniformity around the brachytherapy stepping source as a quicker tool for different treatment lengths and different target distances while maintaining the high quality of the treatment plans, saving time by avoiding the manual isodose shaping and then better suitable treatment for patients.

Attached and unattached fractions of short-lived radon decay products in outdoor environments: effect on the human respiratory system.

The authors developed a model for determining the alpha- and beta-activities per unit volume of air due to radon ((222)Rn), thoron ((220)Rn) and their decay products attached and unattached to the aerosol in the outdoor air at the workplace in natural conditions at different locations in Morocco by using both CR-39 and LR-115 type II solid-state nuclear track detectors. In addition, the percentage of (218)Po, (214)Pb and (214)Po radionuclides attached to the aerosols and the unattached fraction f(j) for different values of the attachment rate were evaluated. Radon and thoron concentrations in outdoor air of the studied different locations were found to vary from 9.20±0.8 to 16.30±1.50 Bq m(-3) and 0.22±0.02 to 1.80±0.20 Bq m(-3), respectively. The committed equivalent doses due to the radon short-lived progeny (218)Po and (214)Po attached and unattached to the aerosol air were evaluated in different tissues of the respiratory tract of the members of the public from the inhalation of outdoor air.

Dead layer thickness characterization of an HPGe detector by measurements and Monte Carlo simulations.

To fully characterize the front dead layer (DL) of an HPGe detector at low photon energy range, its intrinsic efficiency curve was measured using a (241)Am radioactive source in 10-60 keV energy range. A comparison between experimental efficiency and MCNPX results showed that the DL value of 0.4 µm initially quoted by the manufacturer has to be changed to 7.5 µm to reproduce measurements.