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Nat Rev Drug Discov ; 7(11): 900-7, 2008 11.
Artículo en Inglés | MEDLINE | ID: mdl-18927591

RESUMEN

The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.


Asunto(s)
Enfermedades Transmisibles , Bases de Datos Genéticas , Diseño de Fármacos , Genoma , Animales , Enfermedades Transmisibles/tratamiento farmacológico , Enfermedades Transmisibles/microbiología , Enfermedades Transmisibles/parasitología , Enfermedades Transmisibles/virología , Humanos
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