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2.
Drug Discov Ther ; 13(5): 288-293, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31723101

RESUMEN

Paclitaxel, a taxane, is frequently administered intravenously as an anticancer agent. When a peripheral intravenous catheter is used for paclitaxel infusion, clinical nurses often observe signs such as slight swelling at the catheter placement site, lack of blood return, and difficulty in continuing the infusion. However, the cause(s) of such phenomena at the puncture site has not yet been elucidated. The aim of this study was to obtain ultrasonography images of subcutaneous tissues and veins of patients undergoing paclitaxel and carboplatin chemotherapy and compare ultrasonography images taken immediately before catheter removal with those of patients receiving other types of taxanes. We studied 24 patients receiving chemotherapy, including seven receiving paclitaxel and carboplatin chemotherapy, through a peripheral intravenous catheter in a chemotherapy unit for outpatients of a university hospital in Japan. Ultrasonography images of venipuncture sites were obtained before catheter insertion and immediately before catheter removal. We observed subcutaneous edema in the absence of visible manifestations at the puncture sites of all patients undergoing paclitaxel and carboplatin chemotherapy, but not in any patients receiving other types of taxanes. When vesicant agents and vehicles have caused subclinical subcutaneous edema, clinical nurses may detect early slight extravasation by using ultrasonography.


Asunto(s)
Administración Intravenosa/efectos adversos , Extravasación de Materiales Terapéuticos y Diagnósticos/diagnóstico por imagen , Paclitaxel/efectos adversos , Tejido Subcutáneo/patología , Adulto , Carboplatino/administración & dosificación , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Paclitaxel/administración & dosificación , Tejido Subcutáneo/diagnóstico por imagen , Tejido Subcutáneo/efectos de los fármacos , Ultrasonografía
3.
J Infus Nurs ; 40(4): 224-231, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28683001

RESUMEN

This prospective observational study was designed to clarify the rate of peripheral intravenous catheter, especially short peripheral catheter, failures among adult patients in medical and surgical wards. The study was conducted during a 2-month period at a university hospital in Tokyo, Japan. A total of 5316 catheters from 2442 patients were studied. The rate of catheter removal as a result of catheter failure was 18.8%. The reasons for removal in catheter failures were infiltration (41.3%) and pain (19.3%). Pain was a major reason for catheter failure and removal. For this reason, observing changes under the skin before signs and symptoms appear might help prevent catheter failures.


Asunto(s)
Cateterismo Periférico/efectos adversos , Catéteres de Permanencia , Remoción de Dispositivos , Hospitales , Adulto , Cateterismo Periférico/instrumentación , Cateterismo Periférico/métodos , Humanos , Japón , Dolor/etiología , Flebitis/prevención & control , Estudios Prospectivos , Encuestas y Cuestionarios
4.
Eur J Oncol Nurs ; 28: 56-61, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28478856

RESUMEN

PURPOSE: Extravasation, or leakage of vesicant drugs into subcutaneous tissues, causes serious complications such as induration and necrosis in chemotherapy-treated patients. As macroscopic observation may overlook symptoms during infusion, we focused on skin temperature changes at puncture sites and studied thermographic patterns related to induration or necrosis caused by extravasation. METHODS: Outpatients undergoing chemotherapy using peripheral intravenous catheters were enrolled in this prospective observational study. We filmed and classified infrared thermography movies of puncture sites during infusion; ultrasonography was also utilized at puncture sites to observe the subcutaneous condition. Multiple logistic regression analysis was performed to examine the association of thermographic patterns with induration or necrosis observed on the next chemotherapy day. Differences in patient characteristics, puncture sites, and infusions were analyzed by Mann-Whitney's U test and Fisher's exact test according to thermographic patterns. RESULTS: Eight patients developed induration among 74 observations in 62 patients. Among six thermographic patterns, a fan-shaped lower temperature area gradually spreading from the puncture site (fan at puncture site) was significantly associated with induration. Ultrasonography revealed that catheters of patients with fan at puncture site remained in the vein at the end of infusion, indicating that the infusion probably leaked from the puncture site. Patients with fan at puncture site had no significant differences in characteristics and infusion conditions compared with those with the other five thermographic patterns. CONCLUSION: We determined that fan at puncture site was related to induration caused by extravasation. Continuous thermographic observation may enable us to predict adverse events of chemotherapy.


Asunto(s)
Antineoplásicos/efectos adversos , Antineoplásicos/uso terapéutico , Cateterismo Periférico/efectos adversos , Extravasación de Materiales Terapéuticos y Diagnósticos/diagnóstico por imagen , Extravasación de Materiales Terapéuticos y Diagnósticos/etiología , Neoplasias/tratamiento farmacológico , Termografía , Adulto , Anciano , Anciano de 80 o más Años , Temperatura Corporal , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Ultrasonografía
5.
Drug Discov Ther ; 10(2): 117-22, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27210893

RESUMEN

Infiltration is a frequent complication of infusion therapy. We previously demonstrated the usefulness of infrared thermography as an objective method of detecting infiltration in healthy people. However, whether thermography can detect infiltration in clinical settings remains unknown. Therefore, we report two cases where thermography was useful in detecting infiltration at puncture sites. In both cases, tissue changes were verified ultrasonographically. The patients were a 56-year-old male with cholangitis and a 76-year-old female with hepatoma. In both cases, infiltration symptoms such as swelling and erythema occurred one day after the insertion of a peripheral intravenous catheter. Thermographic images from both patients revealed low-temperature areas spreading from the puncture sites; however, these changes were not observed in other patients. The temperature difference between the low-temperature areas and their surrounding skin surface exceeded 1.0°C. Concurrently, ultrasound images revealed that tissues surrounding the vein had a cobblestone appearance, indicating edema. In both patients, subcutaneous tissue changes suggested infiltration and both had low-temperature areas spreading from the puncture sites. Thus, subcutaneous edema may indicate infusion leakage, resulting in a decrease in the temperature of the associated skin surface. These cases suggest that infrared thermography is an effective method of objectively and noninvasively detecting infiltration.


Asunto(s)
Edema/diagnóstico por imagen , Anciano , Carcinoma Hepatocelular/complicaciones , Cateterismo Periférico/efectos adversos , Colangitis/diagnóstico por imagen , Colangitis/etiología , Femenino , Humanos , Rayos Infrarrojos , Neoplasias Hepáticas/complicaciones , Masculino , Persona de Mediana Edad , Piel/diagnóstico por imagen , Tejido Subcutáneo/diagnóstico por imagen , Temperatura , Termografía , Ultrasonografía
6.
Biosci Trends ; 9(6): 414-9, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26781800

RESUMEN

The present observational study aimed to clarify the relationship between the tip position of an indwelling venous catheter and the subcutaneous edema using ultrasonography images. Data were obtained before catheter removal in a medical ward of a university hospital in Tokyo, Japan. Two hundred peripheral intravenous catheters (PIVCs) from 154 patients were observed just before removal. We analyzed data for 194 PIVCs from 150 patients. Subcutaneous edema was observed in 43.8% of ultrasonography images. According to the univariate analysis, insertion site, PIVC tip contact with the vessel wall, and irritant drug's presence were selected as independent variables for logistic regression analysis. Both irritant drug and PIVC tip contact were associated with the presence of subcutaneous edema [adjusted odds ratio (OR) = 2.68, 95% confidence interval (CI) = 1.14-6.33; and OR = 2.01, 95% CI = 1.04-3.88, respectively]. To the best of our knowledge, this is the first study to use ultrasonography to simultaneously observe PIVC tip position and subcutaneous edema. Using ultrasonography to observe PIVC may be a useful method to understand these mechanisms. Medical staff should select an appropriate vein and indwelling catheter to avoid contact of PIVC tip with the vessel wall. Further studies exploring the causality of the relationship between subcutaneous edema, catheter placement, and thrombus formation is required. In addition, further development of nursing skills and medical devices to reduce mechanical stress is required.


Asunto(s)
Cateterismo Periférico/efectos adversos , Catéteres/efectos adversos , Edema/diagnóstico por imagen , Anciano , Anciano de 80 o más Años , Cateterismo Periférico/métodos , Edema/etiología , Humanos , Modelos Logísticos , Persona de Mediana Edad , Oportunidad Relativa , Factores de Riesgo
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