Psoriatic inflammation-induced atypically located venous thromboembolism: A case of immuno-thrombosis.

The immune and hemostatic systems share a common evolutionary origin, both defend against threats to organisms, and inflammation can cause venous thromboembolism. We would like to report a patient with a history of psoriasis, a chronic inflammatory disease, who has been admitted to our clinic with a swollen right arm and collateral veins visible throughout the right upper arm and right pectoral region, which have been present for almost 2 years. Investigations revealed a thrombus extending from the proximal basilic vein into the axillary and subclavian veins but sparing the superior vena cava. Further investigation was performed to reveal any likely cause other than psoriasis, including malignancy, rheumatological disease, or genetic thrombophilia, but none were revealed. This report illustrates that psoriasis-related inflammation can cause atypically located venous thromboembolic events.

Relapse of melanoma presenting as jejunal intussusception.

Melanoma is a relatively rare tumour with tendency to metastasize to the gastrointestinal tract. Metastasis to the intestine constitutes a majority of the gastrointestinal tract melanoma metastases and confers a poor prognosis. While post-mortem studies detect that more than half of the melanoma patients have gastrointestinal tract metastasis, only minority are diagnosed, and even rarer present with intussusception. Intussusception, mainly a paediatric entity, is also seen among adult patients with underlying inflammatory bowel disease or tumour. In this report, we describe a patient with a melanoma in remission who presented with intestinal obstruction after months of vague abdominal complaints. Laparotomy revealed jejunal intussusception and histopathological staining confirmed the melanoma diagnosis. No other distant metastases other than the jejunum were revealed after extensive investigation.