Red and near-infrared light-activated photoelectrochemical nanobiosensors for biomedical target detection.

Photoelectrochemical (PEC) nanobiosensors integrate molecular (bio)recognition elements with semiconductor/plasmonic photoactive nanomaterials to produce measurable signals after light-induced reactions. Recent advancements in PEC nanobiosensors, using light-matter interactions, have significantly improved sensitivity, specificity, and signal-to-noise ratio in detecting (bio)analytes. Tunable nanomaterials activated by a wide spectral radiation window coupled to electrochemical transduction platforms have further improved detection by stabilizing and amplifying electrical signals. This work reviews PEC biosensors based on nanomaterials like metal oxides, carbon nitrides, quantum dots, and transition metal chalcogenides (TMCs), showing their superior optoelectronic properties and analytical performance for the detection of clinically relevant biomarkers. Furthermore, it highlights the innovative role of red light and NIR-activated PEC nanobiosensors in enhancing charge transfer processes, protecting them from biomolecule photodamage in vitro and in vivo applications. Overall, advances in PEC detection systems have the potential to revolutionize rapid and accurate measurements in clinical diagnostic applications. Their integration into miniaturized devices also supports the development of portable, easy-to-use diagnostic tools, facilitating point-of-care (POC) testing solutions and real-time monitoring.

Effect of lung volume preservation during spontaneous breathing trial on successful extubation in patients receiving mechanical ventilation: protocol for a multicenter clinical trial.

BACKGROUND: In standard weaning from mechanical ventilation, a successful spontaneous breathing test (SBT) consisting of 30 min 8 cmH2O pressure-support ventilation (PSV8) without positive end-expiratory pressure (PEEP) is followed by extubation with continuous suctioning; however, these practices might promote derecruitment. Evidence supports the feasibility and safety of extubation without suctioning. Ultrasound can assess lung aeration and respiratory muscles. We hypothesize that weaning aiming to preserve lung volume can yield higher rates of successful extubation. METHODS: This multicenter superiority trial will randomly assign eligible patients to receive either standard weaning [SBT: 30-min PSV8 without PEEP followed by extubation with continuous suctioning] or lung-volume-preservation weaning [SBT: 30-min PSV8 + 5 cmH2O PEEP followed by extubation with positive pressure without suctioning]. We will compare the rates of successful extubation and reintubation, ICU and hospital stays, and ultrasound measurements of the volume of aerated lung (modified lung ultrasound score), diaphragm and intercostal muscle thickness, and thickening fraction before and after successful or failed SBT. Patients will be followed for 90 days after randomization. DISCUSSION: We aim to recruit a large sample of representative patients (N = 1600). Our study cannot elucidate the specific effects of PEEP during SBT and of positive pressure during extubation; the results will show the joint effects derived from the synergy of these two factors. Although universal ultrasound monitoring of lungs, diaphragm, and intercostal muscles throughout weaning is unfeasible, if derecruitment is a major cause of weaning failure, ultrasound may help clinicians decide about extubation in high-risk and borderline patients. TRIAL REGISTRATION: The Research Ethics Committee (CEIm) of the Fundació Unió Catalana d'Hospitals approved the study (CEI 22/67 and 23/26). Registered at ClinicalTrials.gov in August 2023. Identifier: NCT05526053.

Complete atrioventricular block secondary to the BBIBP-CorV vaccine The report of a rare adverse event; the first description in Colombia

Introduction: cardiovascular complications due to COVID-19 infection are very frequent. However, these complications are rarely reported as a vaccine reaction. Case presentation: a female patient with no significant cardiovascular history developed functional class deterioration 14 days after her third dose of the BBIBP-CorV vaccine, along with three syncopal episodes. She was seen at a primary care level and an electrocardiogram was ordered which showed Mobitz 2 atrioventricular block which progressed to a complete block. Molecular tests for COVID-19 infection were negative, as were immunological studies for collagen disease, Chagas, and viral myocarditis. A transthoracic echocardiogram showed no regional kinetic disturbances, and the ejection fraction was preserved at 60%. Cardiac magnetic resonance imaging showed edema in the T2-STIR sequences, and subepicardial enhancement in the medial distal lateral region was compatible with acute myocarditis. The patient required a permanent pacemaker. Discussion: electrical or mechanical dysfunction secondary to a COVID-19 vaccine is anecdotal, with few reports in the literature. In a review of both the 2021 European Society of Cardiology and the 2018 American Heart Association Guidelines on cardiac pacing and cardiac resynchronization therapy, no recommendation was found for these types of events associated with COVID-19 or following vaccination. An international network should be created to report these events and thus determine general management guidelines. For now, the recommendations must be individualized for these patients. (Acta Med Colomb 2022; 48. DOI:https://doi.org/10.36104/amc.2023.2602).

STARS: Un instrumento útil para evaluar la ansiedad a la estadística / STARS: A useful tool to evaluate anxiety to statistics

Resumen. La ansiedad a la estadística se define como un conjunto de reacciones emocionales que generan incomodidad en el individuo, como preocupación excesiva, ideas intrusivas y tensión al asistir a una asignatura que involucre estadística o análisis estadísticos. Para su medición, se han diseñado distintos instrumentos; el más usado es la Statistical Anxiety Rating Scale (STARS). El objetivo del presente estudio fue adaptar y validar la escala STARS en una muestra colombiana para explorar sus propiedades psicométricas. Participaron 357 estudiantes universitarios con edades entre los 18 y 36 años (M= 19.19, DE = 1.87). Los resultados evidencian que las subescalas de la STARS muestran excelentes niveles de fiabilidad; el análisis factorial confirma la estructura de seis dimensiones y se reporta una validez concurrente importante. Se recomienda su uso para investigación y como herramienta para la toma de decisiones en procesos de acompañamiento académico en universidades.

Abstract. Statistics anxiety is defined as a set of emotional reactions that generate discomfort in the students, such as excessive worry, intrusive ideas and tension when they attending a course that involves statistics or statistical analysis. For its measurement, different instruments have been designed; the most used is the Statistical Anxiety Rating Scale (STARS). The objective of the present study was to adapt and validate the STARS in a Colombian sample to explore its psychometric properties. A total of 357 university students with ages between 18 and 36 years participated (X = 19.19, D.E. = 1.87). The results show that the subscales of the STARS show excellent levels of reliability; factor analysis confirms the six-dimensional structure and important concurrent validity is reported. It is recommended for research and as a tool for decision making in academic support processes in universities.

Bienestar subjetivo e imagen corporal en estudiantes universitarias de Arequipa / Subjective wellbeing and body image in college students in Arequipa

Este estudio exploró la correlación entre el bienestar subjetivo y la imagen corporal de las estudiantes mujeres en una universidad de Arequipa. La muestra estuvo constituida de 155 estudiantes mujeres entre los 17 y 24 años de las tres carreras profesionales. Las participantes fueron evaluadas en sus respectivos salones. La validación del Cuestionario de la Imagen Corporal (BSQ) fue calculada con Alfa de Cronbach y se obtuvo un valor de 0.92. Los resultados indicaron que existe una correlación negativa significativa entre el bienestar subjetivo y la imagen corporal (r = -0.478; p < 0.001). Asimismo, se indicó que no existe diferencia estadísticamente significativa entre las carreras de administración y derecho con respecto al bienestar subjetivo (t = 0.201; p > 0.05) y a la imagen corporal (t = -0.606; p > 0.05). Esto muestra que la distorsión de la imagen corporal tiene un impacto negativo en el bienestar subjetivo de las estudiantes universitarias mujeres.

This study explored the correlation between subjective wellbeing and body image of female students at a university in Arequipa. The sample consisted by 155 female students between 17 and 24 years old from the three professional careers. The participants were evaluated in their respective classrooms. The validation of the Body Shape Questionnaire (BSQ) was calculated using CronbachÆs alpha and obtained a value of 0.92. The results indicated that there is significant negative correlation between the subjective wellbeing and body image (r = -0.478; p < 0.001). It was also noted that there is no statistical significant difference between management and law careers with respect to the subjective wellbeing (t = 0.201; p > 0.05) and body image (t = -0.606; p > 0.05). This shows that the distortion of body image has a negative impact on the subjective wellbeing of women university students.

Artículos publicados en EMERGENCIAS entre 2000 y 2004: participación de los urgenciólogos y comparación con su aportación en las revistas indexadas / Scientific papers published in “EMERGENCIAS” from 2000 to 2004: participation of emergency department physicians and comparison with their contribution to indexed journals

Objetivos: Analizar las principales características de la producción científica de los urgenciólogos españoles entre 2000 y 2004, tanto en revistas indexadas por el Scienci Citation Index (SCI) como en la revista EMERGENCIAS, al no encontrarse ésta incluida endicha base de datos. Método: Se revisaron manualmente todos los documentos publicados en EMERGENCIAS durante el período 2000-2004. Se aceptó como documento de un urgenciólogo español si en la filiación figuraba su erradicación en España y cualquiera de las siguientes expresiones identificativas de un servicio-dispositivo de urgencias: urgencias, urgències,urxencias, larrialdiak, larrialdia, emergentziak, emergencias, emergències, emerxencias,emergency, 061, SAMU, 1006, SUC, SEM, SEMSA, SERCAM, 112, DEIAK o EPES. Esta misma estrategia fue la utilizada para la búsqueda en revistas del SCI durante el mismo período. Se registraron y analizaron los principales datos e indicadores bibliométricos utilizados en los estudios previos de nuestro grupo. Para determinar las líneas de investigación se utilizó el índice del Tratado de Medicina de Urgencias de Tintinalli,ligeramente modificado. Resultados: En el periodo estudiado, los urgenciólogos españoles publicaron 594 documentos,290 en EMERGENCIAS y 304 indexados por el SCI. El 51% de ellos fueron realizados por autores pertenecientes a 26 servicios de urgencias hospitalarios y 3 Sistemas de Emergencias, además de la propia SEMES. Hubo diferencias importantes entre la aportación que realizó cada Comunidad y cada Centro a EMERGENCIAS y al SCI en cuanto a la producción científica, en las características bibliométricas y en los temas delos trabajos. Madrid predominó en EMERGENCIAS, Cataluña y Andalucía en el SCI y presentaron una producción balanceada Galicia y el País Vasco. La producción científica publicada en EMERGENCIAS presentaba un menor número de originales, fue firmada por menos autores, el urgenciólogo firmó con mayor frecuencia en primer lugar, hubo una mayor frecuencia de urgenciólogos extrahospitalarios y de pertenencia a un servicio de urgencias independiente. Conclusiones: Los urgenciólogos que publican en EMERGENCIAS aportan un volumen similar de trabajos a los que publican en revistas indexadas en el SCI, aunque la mayoría de características bibliométricas y la temática difieren entre ambas (AU)

Aims: To assess the predominant characteristics of scientific papers published by Spanish clinicians from emergency departments physicians, from 2000 to 2004, in journals indexed in the Science Citation Index (SCI) database and in the journal EMERGENCIAS, which is not included in the aforementioned index. Material and method: All the articles published in the journal EMERGENCIAS during the period 2000-2004 were reviewed. A scientific paper was considered a Spanish emergency department physician document if the setting was Spain and if it included any of the following expressions related to an emergency service: urgencias, urgències, urxencias,larrialdiak, larrialdia, emergentziak, emergencias, emergències, emerxencias, emergency, 061, SAMU, 1006, SUC, SEM,SEMSA, SERCAM, 112, DEIAK or EPES. The same strategy was used to search for journals in the SCI during the sameperiod. All data and bibliometric indicators used in previous studies by our group were registered and analyzed. Aslightly modified index of the text “Tratado de Medicina de Urgencias” by Tintinalli was used to determine the lines ofinvestigation. Results: Throughout the whole study period, the Spanish emergency department clinicians published 594 scientific papers; among which 290 appeared in EMERGENCIAS and 304 were indexed in SCI. 51% were written by clinicians from 26 hospitalary emergency departments and 3 emergency systems, in addition to the SEMES. Significant differences were observed in the contribution of each community are centre to the scientific prroduction, the bibliometriccharacteristics and the topics reported between EMERGENCIAS and the SCI. Madrid prevailed in EMERGENCIAS, Cataloniaand Andalusia in the SCI and Galicia and the Basque Country had a balanced scientific production. EMERGENCIAS had a lower number of original studies, signed by fewer authors, emergency department physicians more frequently signed in first place, and frequency of physicians from extrahospitalary emergency departments and independent emergency services was hister. Conclusions: The volume of studies by emergency department physicians pulishing in EMERGENCIAS is similr to that of studies published in journals indexed in the SCI albeit with differences in the bibliometric characteristics and subjects (AU)

Proyecto EMERGER: primera valoración de resultados / EMERGER project: first outcome assessment

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La nueva imagen de EMERGENCIAS / The new image of EMERGENCIES

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