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1.
Arq. bras. med. vet. zootec. (Online) ; 73(3): 693-702, May-June 2021. tab, graf, mapas
Artículo en Inglés | LILACS, VETINDEX | ID: biblio-1278362

RESUMEN

The objective of this study was to evaluate the spatial distribution of purebred Bos taurus taurus bovine breeds raised in Brazil in association with climatic, physical and socioeconomic variables. The breeds Aberdeen Angus, Ayrshire, Braford, Brangus, Charolais, Devon, Flemish, Hereford, Pinzgauer, Shorthorn and Simental were classified according to their aptitude (milk, meat or dual-purpose). They were spatialized according to their aptitude using state and municipal information. The milk breeds were found in the states of Rio Grande do Sul and Santa Catarina, while the dual-purpose breeds were found in Minas Gerais and Rio Grande do Sul states and the beef breeds were concentrated in the southern region. Only the Aberdeen Angus meat breed showed higher dispersion in other regions. Meat and dual-purpose breeds tended to be raised in regions with lower maximum temperature, average temperature, thermal amplitude and temperature-humidity index. Dual-purpose breeds were found in municipalities with high humidity and altitude, but with a low gross domestic product, little technical guidance received from cooperatives and the government, low control of diseases and parasites, as well as low use of pasture rotation systems. The spatial distribution of Brazilian bovine taurine breeds, regardless of aptitude, was related to climatic, physical and socioeconomic factors.(AU)


O objetivo deste estudo foi avaliar a distribuição espacial de raças bovinas puras Bos taurus taurus criadas no Brasil, associadas a variáveis climáticas, físicas e socioeconômicas. As raças Aberdeen Angus, Ayrshire, Braford, Brangus, Charolês, Devon, Flamenga, Hereford, Pinzgauer, Shorthorn e Simental foram classificadas de acordo com sua aptidão (leite, carne ou duplo-propósito). Elas foram espacializadas de acordo com sua aptidão a partir de informações estaduais e municipais. As raças leiteiras foram encontradas nos estados do Rio Grande do Sul e de Santa Catarina, enquanto as raças de duplo-propósito foram encontradas nos estados de Minas Gerais e Rio Grande do Sul, e as raças de carne concentraram-se na região Sul. Apenas a raça de carne Aberdeen Angus apresentou maior dispersão nas demais regiões. As raças de carne e de duplo-propósito tendem a ser criadas em regiões com menores temperatura máxima, temperatura média, amplitude térmica e índice de temperatura e umidade. As raças de duplo-propósito foram encontradas em municípios com alta umidade e altitude, mas com baixo produto interno bruto, pouca orientação técnica recebida de cooperativas e do governo, baixo controle de doenças e de parasitas e baixo uso de sistema de rotação de pastagens. A distribuição espacial das raças taurinas bovinas brasileiras, independentemente da aptidão, foi relacionada a fatores climáticos, físicos e socioeconômicos.(AU)


Asunto(s)
Animales , Bovinos , Adaptación Biológica , Encuesta Socioeconómica , Clima , Distribución Animal , Crianza de Animales Domésticos/métodos , Brasil
2.
Ecotoxicology ; 29(1): 119-128, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31863232

RESUMEN

Use of pesticides in agroecosystems is considered a major cause of bees diversity losses in the Neotropics, where Plebeia emerina (Friese) and Tetragonisca fiebrigi (Schwarz) (Hymenoptera: Apidae: Meliponini) are wild pollinators of native and crop plants. The aim of this study was to know the acute lethal toxicity of acetamiprid, malathion, phosmet and spinosad insecticides on P. emerina and T. fiebrigi. We obtained the mean concentration and mean lethal dose (LC50 and LD50) and the mean survival of workers after oral and topical exposure to insecticides, respectively. The LC50 values (ng a.i./µl of diet) and the decreasing order of toxicity for P. emerina was spinosad (4.96) > malathion (18.75) > phosmet (97.33) > acetamiprid (4204.06), and for T. fiebrigi also was spinosad (5.65) > malathion (8.39) > phosmet (53.91) > acetamiprid (9841.32), when orally exposed. The LD50 values (ng a.i./bee) and the decreasing order of toxicity for P. emerina was spinosad (1.90) > malathion (10.90) > phosmet (19.54) > acetamiprid (6216.55) and for T. fiebrigi was malathion (29.29) ≥ spinosad (29.79) > phosmet (41.95) > acetamiprid (1421.23), when topically exposed. The mean survival (hours) of contaminated bees by malathion, phosmet, and spinosad, was 11.81, 7.20, and 12.32 for P. emerina and 8.55, 7.20, and 13.34 for T. fiebrigi when orally exposed; and was 4.87, 9.87 and 11.17 for P. emerina, and 4.87, 4.76, and 19.05 for T. fiebrigi when topically exposed. Malathion, phosmet, and spinosad were highly toxic, while acetamiprid was moderately toxic. Our results indicated that the insecticides tested, mainly malathion, phosmet, and spinosad may be harmful to P. emerina and T. fiebrigi, making it essential to propose measures to minimize their impact on wild pollinators.


Asunto(s)
Abejas/fisiología , Himenópteros/fisiología , Insecticidas/toxicidad , Animales , Abejas/efectos de los fármacos , Combinación de Medicamentos , Himenópteros/efectos de los fármacos , Dosificación Letal Mediana , Macrólidos , Malatión , Neonicotinoides , Polinización
3.
Neotrop Entomol ; 47(1): 152-159, 2018 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28378269

RESUMEN

Grapholita molesta (Busck) is one of the main pests in apple crops in Brazil, where it is controlled by mating disruption (MD) with the use of the synthetic sex pheromone. However, sex-pheromone-based monitoring is not effective in MD-treated areas and may result in losses in production. This work has defined a trap model and a bait for luring G. molesta adults in MD apple orchards. The experiments were conducted in commercial apple orchards located in São Joaquim, SC, Brazil. Three trap models-McPhail, Pot, and Ajar-and three baits-grape juice (25%) (GJ), sugarcane molasses (25%) (SM), and a solution containing brown sugar (8.69%) and terpinyl acetate (0.05%) (TAS)-were assessed for luring G. molesta adults in areas subjected to the mating disruption. The assessments were performed weekly by collecting the insects caught in the traps. In addition, time needed to replace traps was also assessed, as well as the selectivity of the trap/bait set. In the laboratory, G. molesta adults were sexed, and the females were dissected to confirm reproductive status. We discuss our results and sugarcane molasses (25%) captured the least number of G. molesta adults regardless of the tested traps. The Ajar/TAS, Pot/TAS, and McPhail/GJ captured the largest number of G. molesta adults. The Ajar/TAS was the most selective and easier to handle. TAS was efficient in catching G. molesta until 14 days after preparation of the solution. Ajar/TAS has potential to be used in the monitoring of G. molesta in apple orchards.


Asunto(s)
Control de Insectos/instrumentación , Control de Insectos/métodos , Mariposas Nocturnas , Animales , Brasil , Femenino , Jugos de Frutas y Vegetales , Masculino , Malus , Melaza , Azúcares , Terpenos
4.
Sci Rep ; 6: 28871, 2016 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-27364139

RESUMEN

Defects in semiconductors can exhibit multiple charge states, which can be used for charge storage applications. Here we consider such charge storage in a series of oxygen deficient phases of TiO2, known as Magnéli phases. These Magnéli phases (TinO2n-1) present well-defined crystalline structures, i.e., their deviation from stoichiometry is accommodated by changes in space group as opposed to point defects. We show that these phases exhibit intermediate bands with an electronic quadruple donor transitions akin to interstitial Ti defect levels in rutile TiO2. Thus, the Magnéli phases behave as if they contained a very large pseudo-defect density: ½ per formula unit TinO2n-1. Depending on the Fermi Energy the whole material will become charged. These crystals are natural charge storage materials with a storage capacity that rivals the best known supercapacitors.

5.
J Phys Condens Matter ; 28(3): 035801, 2016 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-26702713

RESUMEN

Tantalum pentoxide (Ta2O5) is a wide-gap semiconductor that presents good catalytic and dielectric properties, conferring to this compound promising prospective use in a variety of technological applications. However, there is a lack of understanding regarding the relations among its crystalline phases, as some of them are not even completely characterized and there is currently no agreement about which models better explain the crystallographic data. Additionally, its phase diagram is unknown. In this work we performed first-principles density functional theory calculations to study the structural properties of the different phases and models of Ta2O5, the equation of state and the zone-centered vibrational frequencies. From our results, we conclude that the phases that are built up from only distorted octahedra instead of combinations with pentagonal and/or hexagonal bipyramids are energetically more favorable and dynamically stable. More importantly, this study establishes that, given the pressure range considered, the B-phase is the most favorable structure and there is no a crystallographic phase transition to another phase at high-pressure. Additionally, for the equilibrium volume of the B-phase and the λ-model, the description of the electronic structure and optical properties were performed using semi-local and hybrid functionals.


Asunto(s)
Óxidos/química , Tantalio/química , Cristalografía por Rayos X , Estabilidad de Medicamentos , Modelos Moleculares , Conformación Molecular , Transición de Fase , Teoría Cuántica
6.
J Clin Endocrinol Metab ; 99(12): E2652-60, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25127195

RESUMEN

CONTEXT: Kisspeptin is a recently identified hormone encoded by the KISS1 gene, playing a critical role in human reproduction. Plasma kisspeptin levels rise dramatically during normal pregnancy due to placental synthesis, which implicates it as a potential tool for assessing risks of pregnancy complications. No previous prospective study has investigated the association between plasma kisspeptin and risk of miscarriage. OBJECTIVE: The objective of the study was to determine whether a single plasma kisspeptin or serum human chorionic gonadotropin (hCG) measurement in asymptomatic women attending their booking antenatal visit is associated with miscarriage. DESIGN: This was a prospective cohort study. SETTING: The study was conducted at a tertiary obstetric center. PARTICIPANTS: A total of 993 asymptomatic pregnant women with a gestation of 6 weeks or longer attending routine antenatal booking visit were recruited between January 2010 and December 2012. MAIN OUTCOME MEASURES: Plasma kisspeptin and serum hCG were measured during the antenatal booking visit. Pregnancy outcome was recorded prospectively. RESULTS: Plasma kisspeptin correlated with gestation (r(2) = 0.57; P < .0001). Gestational age-corrected (multiples of median) plasma kisspeptin was 60.4% lower (P < .001), and multiples of median-hCG was 36.1% lower (P < .001) in women later diagnosed with miscarriage compared with women without miscarriage. Increased plasma kisspeptin was associated with reduced miscarriage risk, even after adjusting for age, body mass index, gestational age, smoking, and blood pressure [odds ratio 0.13 (95% confidence interval 0.08-0.22), P = .0001]. Kisspeptin had a higher diagnostic performance for miscarriage than hCG (receiver-operator characteristic-area under the curve 0.899 ± 0.025 plasma kisspeptin; 0.775 ± 0.040, serum hCG, P < .01 vs plasma kisspeptin). CONCLUSION: Our data suggest for the first time that a single plasma kisspeptin measurement taken during the antenatal booking visit provides a potential novel marker for identifying asymptomatic pregnant women at a gestation of 6 weeks or greater at increased risk of miscarriage.


Asunto(s)
Aborto Espontáneo/sangre , Kisspeptinas/sangre , Atención Prenatal , Aborto Espontáneo/epidemiología , Adulto , Gonadotropina Coriónica/sangre , Estudios de Cohortes , Femenino , Edad Gestacional , Humanos , Embarazo , Primer Trimestre del Embarazo , Estudios Prospectivos , Riesgo
7.
Braz J Med Biol Res ; 44(9): 933-8, 2011 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-21956536

RESUMEN

Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for this association is that ouabain binds to the α-subunit of the Na(+) pump, inhibiting its activity. Inhibition of this pump increases intracellular Na(+), which reduces the activity of the sarcolemmal Na(+)/Ca(2+) exchanger and thereby reduces Ca(2+) extrusion. Consequently, intracellular Ca(2+) increases and is taken up by the sarcoplasmic reticulum, which, upon activation, releases more calcium and increases the vascular smooth muscle tone. In fact, acute treatment with ouabain enhances the vascular reactivity to vasopressor agents, increases the release of norepinephrine from the perivascular adrenergic nerve endings and promotes increases in the activity of endothelial angiotensin-converting enzyme and the local synthesis of angiotensin II in the tail vascular bed. Additionally, the hypertension induced by ouabain has been associated with central mechanisms that increase sympathetic tone, subsequent to the activation of the cerebral renin-angiotensin system. Thus, the association with peripheral mechanisms and central mechanisms, mainly involving the renin-angiotensin system, may contribute to the acute effects of ouabain-induced elevation of arterial blood pressure.


Asunto(s)
Presión Sanguínea/efectos de los fármacos , Cardiotónicos/farmacología , Hipertensión/inducido químicamente , Ouabaína/farmacología , Angiotensina II/biosíntesis , Animales , Calcio/metabolismo , Cardiotónicos/administración & dosificación , Cardiotónicos/metabolismo , Sistema Nervioso Central/efectos de los fármacos , Humanos , Hipertensión/metabolismo , Inyecciones Intravenosas , Norepinefrina/metabolismo , Ouabaína/administración & dosificación , Ouabaína/metabolismo , Peptidil-Dipeptidasa A/metabolismo , Ratas , Sistema Renina-Angiotensina/efectos de los fármacos , ATPasa Intercambiadora de Sodio-Potasio/efectos de los fármacos , ATPasa Intercambiadora de Sodio-Potasio/fisiología
8.
Braz. j. med. biol. res ; 44(9): 933-938, Sept. 2011. ilus
Artículo en Inglés | LILACS | ID: lil-599668

RESUMEN

Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for this association is that ouabain binds to the α-subunit of the Na+ pump, inhibiting its activity. Inhibition of this pump increases intracellular Na+, which reduces the activity of the sarcolemmal Na+/Ca2+ exchanger and thereby reduces Ca2+ extrusion. Consequently, intracellular Ca2+ increases and is taken up by the sarcoplasmic reticulum, which, upon activation, releases more calcium and increases the vascular smooth muscle tone. In fact, acute treatment with ouabain enhances the vascular reactivity to vasopressor agents, increases the release of norepinephrine from the perivascular adrenergic nerve endings and promotes increases in the activity of endothelial angiotensin-converting enzyme and the local synthesis of angiotensin II in the tail vascular bed. Additionally, the hypertension induced by ouabain has been associated with central mechanisms that increase sympathetic tone, subsequent to the activation of the cerebral renin-angiotensin system. Thus, the association with peripheral mechanisms and central mechanisms, mainly involving the renin-angiotensin system, may contribute to the acute effects of ouabain-induced elevation of arterial blood pressure.


Asunto(s)
Animales , Humanos , Ratas , Presión Sanguínea/efectos de los fármacos , Cardiotónicos/farmacología , Hipertensión/inducido químicamente , Ouabaína/farmacología , Angiotensina II/biosíntesis , Calcio/metabolismo , Cardiotónicos/administración & dosificación , Cardiotónicos/metabolismo , Sistema Nervioso Central/efectos de los fármacos , Hipertensión/metabolismo , Inyecciones Intravenosas , Norepinefrina , Ouabaína/administración & dosificación , Ouabaína/metabolismo , Peptidil-Dipeptidasa A/metabolismo , Sistema Renina-Angiotensina/efectos de los fármacos , ATPasa Intercambiadora de Sodio-Potasio/efectos de los fármacos , ATPasa Intercambiadora de Sodio-Potasio/fisiología
9.
Braz. j. med. biol. res ; 43(8): 767-776, Aug. 2010. tab, ilus
Artículo en Inglés | LILACS | ID: lil-554957

RESUMEN

We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to phenylephrine (PHE) were investigated before and after 0.18 ìg/kg ouabain administration (N = 6). The influence of hexamethonium (N = 6), canrenone (N = 6), enalapril (N = 6), and losartan (N = 6) on ouabain actions was evaluated. Ouabain increased BP (SAP: 137 ± 5.1 to 150 ± 4.7; DAP: 93.7 ± 7.7 to 116 ± 3.5 mmHg; P<0.05) but did not change PHE pressor reactivity. Hexamethonium reduced basal BP in control but not in ouabain-treated rats. However, hexamethonium + ouabain increased DAP sensitivity to PHE. Canrenone did not affect basal BP but blocked ouabain effects on SAP. However, after canrenone + ouabain administration, DAP pressor reactivity to PHE still increased. Enalapril and losartan reduced BP and abolished SAP and DAP responses to ouabain. Enalapril + ouabain reduced DAP reactivity to PHE, while losartan + ouabain reduced SAP and DAP reactivity to PHE. In conclusion, a small dose of ouabain administered to SHR increased BP without altering PHE pressor reactivity. Although the renin-angiotensin system (RAS), Na+ pump and autonomic reflexes are involved in the effects of ouabain on PHE reactivity, central mechanisms might blunt the actions of ouabain on PHE pressor reactivity. The effect of ouabain on SAP seems to depend on the inhibition of both Na+ pump and RAS, whereas the effect on DAP seems to depend only on RAS.


Asunto(s)
Animales , Masculino , Ratas , Inhibidores Enzimáticos/farmacología , Hipertensión/inducido químicamente , Ouabaína/farmacología , Sistema Renina-Angiotensina/efectos de los fármacos , ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidores , Antihipertensivos/farmacología , Hipertensión/prevención & control , Fenilefrina/farmacología , Ratas Endogámicas SHR , Sistema Renina-Angiotensina/fisiología
10.
Braz J Med Biol Res ; 43(8): 767-76, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20602018

RESUMEN

We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to phenylephrine (PHE) were investigated before and after 0.18 microg/kg ouabain administration (N = 6). The influence of hexamethonium (N = 6), canrenone (N = 6), enalapril (N = 6), and losartan (N = 6) on ouabain actions was evaluated. Ouabain increased BP (SAP: 137 +/- 5.1 to 150 +/- 4.7; DAP: 93.7 +/- 7.7 to 116 +/- 3.5 mmHg; P<0.05) but did not change PHE pressor reactivity. Hexamethonium reduced basal BP in control but not in ouabain-treated rats. However, hexamethonium + ouabain increased DAP sensitivity to PHE. Canrenone did not affect basal BP but blocked ouabain effects on SAP. However, after canrenone + ouabain administration, DAP pressor reactivity to PHE still increased. Enalapril and losartan reduced BP and abolished SAP and DAP responses to ouabain. Enalapril + ouabain reduced DAP reactivity to PHE, while losartan + ouabain reduced SAP and DAP reactivity to PHE. In conclusion, a small dose of ouabain administered to SHR increased BP without altering PHE pressor reactivity. Although the renin-angiotensin system (RAS), Na+ pump and autonomic reflexes are involved in the effects of ouabain on PHE reactivity, central mechanisms might blunt the actions of ouabain on PHE pressor reactivity. The effect of ouabain on SAP seems to depend on the inhibition of both Na+ pump and RAS, whereas the effect on DAP seems to depend only on RAS.


Asunto(s)
Inhibidores Enzimáticos/farmacología , Hipertensión/inducido químicamente , Ouabaína/farmacología , Sistema Renina-Angiotensina/efectos de los fármacos , ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidores , Animales , Antihipertensivos/farmacología , Hipertensión/prevención & control , Masculino , Fenilefrina/farmacología , Ratas , Ratas Endogámicas SHR , Sistema Renina-Angiotensina/fisiología
11.
Braz J Med Biol Res ; 41(5): 416-23, 2008 May.
Artículo en Inglés | MEDLINE | ID: mdl-18516469

RESUMEN

The investigation of resistance vessels is generally costly and difficult to execute. The present study investigated the diameters and the vascular reactivity of different segments of the rat tail artery (base, middle, and tail end) of 30 male Wister rats (EPM strain) to characterize a conductance or resistance vessel, using a low-cost simple technique. The diameters (mean +/- SEM) of the base and middle segments were 471 +/- 4.97 and 540 +/- 8.39 microm, respectively, the tail end was 253 +/- 2.58 microm. To test reactivity, the whole tail arteries or segments were perfused under constant flow and the reactivity to phenylephrine (PHE; 0.01-300 microg) was evaluated before and after removal of the endothelium or drug administration. The maximal response (Emax) and sensitivity (pED50) to PHE of the whole tail and the base segment increased after endothelium removal or treatment with 100 microM L-NAME, which suggests modulation by nitric oxide. Indomethacin (10 microM) and tetraethylammonium (5 mM) did not change the Emax or pED50 of these segments. PHE and L-NAME increased the pED50 of the middle and the tail end only and indomethacin did not change pED50 or Emax. Tetraethylammonium increased the sensitivity only at the tail end, which suggests a blockade of vasodilator release. Results indicate that the proximal segment of the tail artery possesses a diameter compatible with a conductance vessel, while the tail end has the diameter of a resistance vessel. In addition, the vascular reactivity to PHE in the proximal segment is nitric oxide-dependent, while the tail end is dependent on endothelium-derived hyperpolarizing factor.


Asunto(s)
Presión Sanguínea/fisiología , Endotelio Vascular/fisiología , Cola (estructura animal)/irrigación sanguínea , Resistencia Vascular/fisiología , Animales , Arterias/anatomía & histología , Arterias/efectos de los fármacos , Arterias/fisiología , Presión Sanguínea/efectos de los fármacos , Endotelio Vascular/efectos de los fármacos , Masculino , Modelos Animales , Fenilefrina/farmacología , Ratas , Ratas Wistar , Flujo Sanguíneo Regional/efectos de los fármacos , Flujo Sanguíneo Regional/fisiología , Resistencia Vascular/efectos de los fármacos , Vasoconstrictores/farmacología
12.
Braz. j. med. biol. res ; 41(5): 416-423, May 2008. graf, tab
Artículo en Inglés | LILACS | ID: lil-484435

RESUMEN

The investigation of resistance vessels is generally costly and difficult to execute. The present study investigated the diameters and the vascular reactivity of different segments of the rat tail artery (base, middle, and tail end) of 30 male Wister rats (EPM strain) to characterize a conductance or resistance vessel, using a low-cost simple technique. The diameters (mean ± SEM) of the base and middle segments were 471 ± 4.97 and 540 ± 8.39 µm, respectively, the tail end was 253 ± 2.58 µm. To test reactivity, the whole tail arteries or segments were perfused under constant flow and the reactivity to phenylephrine (PHE; 0.01-300 µg) was evaluated before and after removal of the endothelium or drug administration. The maximal response (Emax) and sensitivity (pED50) to PHE of the whole tail and the base segment increased after endothelium removal or treatment with 100 µM L-NAME, which suggests modulation by nitric oxide. Indomethacin (10 µM) and tetraethylammonium (5 mM) did not change the Emax or pED50 of these segments. PHE and L-NAME increased the pED50 of the middle and the tail end only and indomethacin did not change pED50 or Emax. Tetraethylammonium increased the sensitivity only at the tail end, which suggests a blockade of vasodilator release. Results indicate that the proximal segment of the tail artery possesses a diameter compatible with a conductance vessel, while the tail end has the diameter of a resistance vessel. In addition, the vascular reactivity to PHE in the proximal segment is nitric oxide-dependent, while the tail end is dependent on endothelium-derived hyperpolarizing factor.


Asunto(s)
Animales , Masculino , Ratas , Presión Sanguínea/fisiología , Endotelio Vascular/fisiología , Cola (estructura animal)/irrigación sanguínea , Resistencia Vascular/fisiología , Arterias/anatomía & histología , Arterias/efectos de los fármacos , Arterias/fisiología , Presión Sanguínea/efectos de los fármacos , Endotelio Vascular/efectos de los fármacos , Modelos Animales , Fenilefrina/farmacología , Ratas Wistar , Flujo Sanguíneo Regional/efectos de los fármacos , Flujo Sanguíneo Regional/fisiología , Resistencia Vascular/efectos de los fármacos , Vasoconstrictores/farmacología
13.
J Biomed Mater Res B Appl Biomater ; 73(1): 109-16, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15660438

RESUMEN

In this study, the in vitro corrosion resistance of a superferritic stainless steel in naturally aerated Hank's solution at 37 degrees C has been determined to evaluate the steel for use as a biomaterial. The potentiodynamic polarization method and electrochemical impedance spectroscopy (EIS) were used to determine the corrosion resistance. The polarization results showed very low current densities at the corrosion potential and electrochemical behavior typical of passive metals. At potentials above 0.75 V (SCE), and up to that of the oxygen evolution reaction, the superferritic steel exhibited transpassive behavior followed by secondary passivation. The superferritic stainless steel exhibited high pitting resistance in Hank's solution. This steel did not reveal pits even after polarization to 3000 mV (SCE). The EIS results indicated high impedance values at low frequencies, supporting the results obtained from the polarization measurements. The results obtained for the superferritic steel have been compared with those of the Ti-13Nb-13Zr alloy and an austenitic stainless steel, as Ti alloys are well known for their high corrosion resistance and biocompatibility, and the austenitic stainless steel is widely used as an implant material. The cytotoxicity tests indicated that the superferritic steel, the austenitic steel, and the Ti-13Nb-13Zr alloy were not toxic. Based on corrosion resistance and cytotoxicity results, the superferritic stainless steel can be considered as a potential biomaterial.


Asunto(s)
Materiales Biocompatibles/química , Soluciones Isotónicas/química , Acero Inoxidable/química , Titanio/farmacología , Aleaciones , Cromo/química , Corrosión , Impedancia Eléctrica , Electroquímica/métodos , Concentración de Iones de Hidrógeno , Técnicas In Vitro , Ensayo de Materiales , Microscopía Electrónica de Rastreo , Oxígeno/química , Potenciometría , Análisis Espectral/métodos , Acero , Propiedades de Superficie , Temperatura , Resistencia a la Tracción , Factores de Tiempo , Titanio/química
15.
Int J Infect Dis ; 4(3): 153-7, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-11179919

RESUMEN

OBJECTIVE: Mucocutaneous leishmaniasis is widely distributed in Brazil, with Leishmania (Viannia) braziliensis being the major etiologic agent. The currently recommended therapy is limited by its parenteral use, high toxicity, and variable efficacy. A clinical pilot study was conducted to analyze itraconazole as an oral alternative for the treatment of mucocutaneous leishmaniasis. METHODS: Ten patients were enrolled to receive 4 mg/kg per day (up to 400 mg/d) itraconazole for 6 weeks on an outpatient regimen. Diagnosis was based on clinical otorhinolaryngologic examination, followed by a specific serologic reaction, the Montenegro test and pathologic analysis with immunohistochemical reaction. Healing of the lesions was confirmed by clinical otorhinolaryngologic examination. Side effects were monitored by general clinical assessment, hemoglobin determination, leukocyte counts, and liver function tests, all performed before, during, and 1 month after the end of treatment. RESULTS: Six of 10 patients presented healed lesions 3 months after treatment, with a sustained therapeutic response for at least a median period of 14.5 months (range, 12-18 mo). Side effects were not observed. CONCLUSIONS: This pilot study demonstrated that itraconazole can be an effective and well-tolerated alternative for the treatment of mucocutaneous leishmaniasis. Further randomized studies and double blind controlled trials are needed to assess the benefits of this drug in the treatment of mucocutaneous leishmaniasis.


Asunto(s)
Itraconazol/uso terapéutico , Leishmaniasis Mucocutánea/tratamiento farmacológico , Adulto , Anciano , Anciano de 80 o más Años , Esquema de Medicación , Femenino , Humanos , Leishmaniasis Mucocutánea/diagnóstico , Masculino , Persona de Mediana Edad , Proyectos Piloto , Resultado del Tratamiento
16.
An. bras. dermatol ; 59(4): 202-8, 1984.
Artículo en Portugués | LILACS | ID: lil-22993

RESUMEN

Neste estudo foram incluidos 148 doentes, sendo 65 com pitiriase versicolor e 83 com dermatofitoses, submetidos a tratamento com ketoconazole por via oral. A dose diaria foi de 200mg (um comprimido) durante duas a quatro semanas para os casos de pitiriase versicolor e de quatro a oito semanas para os de dermatofitoses. O tratamento determinou, nos doentes de pitiriase versicolor, cura clinica e micologica em 50 (78,1%), apenas cura clinica em dois (3,1%) e cura micologica em um (1,6%). Nos doentes com dermatofitoses, em 69 (84,1%) houve cura clinica e micologica, quatro (4,9%) apresentaram cura micologica e cinco (6,1%) tiveram apenas cura clinica. Efeitos colaterais foram observados em 11 doentes (7,4%), sendo que dois necessitaram abandonar o tratamento por intolerancia (um teve nauseas de grau moderado e outro, nauseas, vomitos e tonturas de grau moderado, ambos no 1o. dia de tratamento).O ketoconazole por via oral demonstrou ser bastante eficaz no tratamento de pitiriase versicolor e de dermatofitoses


Asunto(s)
Adulto , Persona de Mediana Edad , Humanos , Masculino , Femenino , Dermatomicosis , Cetoconazol
17.
Recurso Educacional Abierto en Portugués | CVSP - Brasil | ID: cfc-182475

RESUMEN

Discursa sobre a importância da epidemiologia para a Saúde Coletiva e sobre o 8º Congresso Brasileiro de Epidemiologia. Afirma, ainda, que vivemos um momento de grandes desafios, como o rápido envelhecimento da população e a epidemia de crack, o elevado número de morte de jovens, principalmente negros, e o alto índice de acidentes de trânsito. Sobre a economia, Padilha ressaltou que nenhum país do mundo enriqueceu sem ter a saúde como centro de seu projeto econômico de desenvolvimento. Arquivo disponível para audição e/ou download no link ao lado.

18.
Recurso Educacional Abierto en Portugués | CVSP - Brasil | ID: cfc-182404

RESUMEN

O principal objetivo do seminário, foi debater os cinco temas: "Governança para enfrentar as causas das iniqüidades em saúde: implementação de açoes sobre os determinantes sociais da saúde"; "O papel do setor da saúde, incluindo programas de saúde pública, na redução das iniquidades em saúde"; "Promovendo a participação: liderança comunitária para as ações sobre os determinantes sociais"; "Ação global sobre os determinantes sociais: coordenando as prioridades e as partes interessadas"; "Monitorando o progresso: medição e análise para fundamentar as políticas sobre os determinantes sociais" que serão abordados na CMDSS que se realizará no Brasil, na cidade do Rio de Janeiro, de 19 a 21 de outubro de 2011. Arquivo disponível para audição e/ou download no ícone ao lado.

19.
Recurso Educacional Abierto en Portugués | CVSP - Brasil | ID: cfc-182333

RESUMEN

A oficina teve como objetivo propiciar um intercâmbio de conhecimentos e reflexão sistemática sobre os sistemas de saúde à luz dos desafios da universalidade, integralidade e equidade. Visa identificar fortalezas e debilidades que permitam o desenvolvimento de linhas de cooperação e trabalho para o Instituto. Arquivo disponível para audição e/ou download no ícone ao lado.

20.
Recurso Educacional Abierto en Portugués | CVSP - Brasil | ID: cfc-182262

RESUMEN

Aula proferida pelo Ministro da Saúde, Alexandre Padilha, no dia 20 de maio de 2011. O evento foi transmitido em tempo real pela internet e teve 46 acessos, sendo que grande parte dos acessos foram realizados para grupos de pessoas. O ministro também descerrou a placa de inauguração do novo curso. Arquivo disponível no link ao lado.

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