RESUMEN
The experimental data on a structural-and-functional status of erythrocyte membranes in ground-based simulation of human extravehicular activity (EVA) are discussed. The changes in the structure and function of erythrocyte membrane were determined from the fixation of lipophilic ions, specific activity of ion-transporting adenosine triphosphatases and content of the products of peroxide oxidation of lipids (POL) in plasma. On exposure to hypobaric hyperoxia during real EVA the membrane status changes are associated with the activation of a cascade of POL processes.
Asunto(s)
Adenosina Trifosfatasas/metabolismo , Membrana Eritrocítica/metabolismo , Peroxidación de Lípido , Vuelo Espacial , Adulto , Prueba de Esfuerzo , Medio Ambiente Extraterrestre , Humanos , Masculino , Modelos BiológicosAsunto(s)
Quemaduras/cirugía , Trasplante de Piel , Trasplante Heterólogo , Animales , Desbridamiento/métodos , Humanos , Terapia por Láser , Necrosis , Porcinos , Trasplante AutólogoRESUMEN
An original technique developed by the authors was used in 51 experiments on dogs. Under study were the ECG-dynamics, the volume of the retrograde bloodflow and blood pressure in the splenic and anterior interventricular arteries before and after creating the retrograde spleno-coronary anastomosis. The results of studies of hemodynamics at this operation have confirmed its physiological adequacy.