The protective role of sulforaphane and Homer1a in retinal ischemia-reperfusion injury: Unraveling the neuroprotective interplay.

AIMS: Retinal ischemia/reperfusion (I/R) injury is a common pathological basis for various ophthalmic diseases. This study aimed to investigate the potential of sulforaphane (SFN) and Homer1a in regulating cell apoptosis induced by retinal I/R injury and to explore the underlying regulatory mechanism between them. MATERIALS AND METHODS: In in vivo experiments, C57BL/6J mice and Homer1flox/-/Homer1a+/-/Nestin-Cre+/- mice were used to construct retinal I/R injury models. In vitro experiments utilized the oxygen-glucose deprivation-reperfusion (OGD/R) injury model with primary retinal ganglion cells (RGCs). The effects of Homer1a and SFN on cell apoptosis were observed through pathological analyses, flow cytometry, and visual electrophysiological assessments. KEY FINDINGS: We discovered that after OGD/R injury, apoptosis of RGCs and intracellular Ca2+ activity significantly increased. However, these changes were reversed upon the addition of SFN, and similar observations were reproduced in in vivo studies. Furthermore, both in vivo and in vitro studies confirmed the upregulation of Homer1a after I/R, which could be further enhanced by the administration of SFN. Moreover, upregulation of Homer1a resulted in a reduction in cell apoptosis and pro-apoptotic proteins, while downregulation of Homer1a had the opposite effect. Flash visual evoked potential, oscillatory potentials, and escape latency measurements in mice supported these findings. Furthermore, the addition of SFN strengthened the neuroprotective effects in the OGD/R + H+ group but weakened them in Homer1flox/-/Homer1a+/-/Nestin-Cre+/- mice. SIGNIFICANCE: These results indicate that Homer1a plays a significant role in the therapeutic potential of sulforaphane for retinal I/R injury, thereby providing a theoretical basis for clinical treatment.

An Overview of Bipolar Disorder Diagnosis Using Machine Learning Approaches: Clinical Opportunities and Challenges.

Objective: Automatic diagnosis of psychiatric disorders such as bipolar disorder (BD) through machine learning techniques has attracted substantial attention from psychiatric and artificial intelligence communities. These approaches mostly rely on various biomarkers extracted from electroencephalogram (EEG) or magnetic resonance imaging (MRI)/functional MRI (fMRI) data. In this paper, we provide an updated overview of existing machine learning-based methods for bipolar disorder (BD) diagnosis using MRI and EEG data. Method : This study is a short non-systematic review with the aim of describing the current situation in automatic diagnosis of BD using machine learning methods. Therefore, an appropriate literature search was conducted via relevant keywords for original EEG/MRI studies on distinguishing BD from other conditions, particularly from healthy peers, in PubMed, Web of Science, and Google Scholar databases. Results: We reviewed 26 studies, including 10 EEG studies and 16 MRI studies (including structural and functional MRI), that used traditional machine learning methods and deep learning algorithms to automatically detect BD. The reported accuracies for EEG studies is about 90%, while the reported accuracies for MRI studies remains below the minimum level for clinical relevance, i.e. about 80% of the classification outcome for traditional machine learning methods. However, deep learning techniques have generally achieved accuracies higher than 95%. Conclusion: Research utilizing machine learning applied to EEG signals and brain images has provided proof of concept for how this innovative technique can help psychiatrists distinguish BD patients from healthy people. However, the results have been somewhat contradictory and we must keep away from excessive optimistic interpretations of the findings. Much progress is still needed to reach the level of clinical practice in this field.

Psychological capital in university students: analysis of scientific activity in the scopus database.

Lately there has been an increase in the number of publications on psychological capital, especially in the specialty of organizational psychology, and not so much in the field of educational psychology. This study aims to analyze the main bibliometric indicators of production, collaboration and impact of scientific literature related to psychological capital in university students. We searched the Scopus database for documents using the comprehensive search strategy until June 27, 2021. Data were collected regarding title, keywords, authors, co-authors, citations received, details of the most productive journals, year of publication, countries, and institutions. From 2009 to 2021, 82 documents were published, mainly from countries such as China, Australia, the United Kingdom, the United States and Spain; the most productive journal was the so-called Revista Argentina de Clínica Psicológica while Curtin University was the most influential institution in the subject of study. The author's co-occurrence network analysis, trend topics, and keyword analysis highlighted themes involving psychological capital with educational and health variables in college students. The findings can help both academics and professionals to obtain an overview of advances in the subject and thus identify important gaps in the literature and propose promising new lines of research.

Factores relacionados con el abandono de la suplementación de los micronutrientes en niños / Factors related to the abandonment of micronutrient supplementation in children / Fatores relacionados ao abandono da suplementação de micronutrientes em crianças

La anemia es uno de los problemas más importantes de la salud pública, viéndose un crecimiento sostenido en los últimos años. Existen diversos factores relacionados al abandono de la suplementación de los micronutrientes. Objetivo. Establecer los factores relacionados con el abandono de la suplementación de los micronutrientes en niños de 6 a 36 meses atendidos en un Centro Materno Infantil. Materiales y métodos. El enfoque fue cuantitativo, de tipo básica, diseño no experimental transversal. La población estuvo constituida por 120 pacientes neonatos y la muestra fue de 80 pacientes neonatos del Centro Materno infantil, elegidos mediante muestreo no probabilístico, con la técnica de la encuesta y el instrumento fue el cuestionario. Resultados. El 25% presentó niveles inadecuados, el 62.5% presentó niveles moderados y el 12.5% presentó niveles adecuados de uso de suplementación de los micronutrientes. Conclusiones. El abandono de la suplementación de los micronutrientes se encuentra asociado con los factores generales del infante, como la edad, sexo, y número de hijo, tipo de seguro y número de micronutriente y además dependen de los factores relacionados al cuidador a edad del cuidador, grado de instrucción, estado civil, número de hijos, procedencia y ocupación, tal como muestra al prueba de la independencia de Chi-cuadrado y el p< 0.05, y se establecen que los factores generales del niño y los Factores relacionados al cuidador se encuentran asociados en la suplementación de los micronutrientes.

Anemia is one of the most important public health problems, with a sustained growth in recent years. There are several factors related to the abandonment of micronutrient supplementation. Objective. To establish the factors related to the abandonment of micronutrient supplementation in children aged 6 to 36 months attended in a Maternal and Child Center. Materials and methods. The approach was quantitative, basic, non-experimental cross-sectional design. The population consisted of 120 neonatal patients and the sample consisted of 80 neonatal patients of the Maternal and Child Center, chosen by non-probabilistic sampling, with the survey technique and the instrument was the questionnaire. Results. The 25% presented inadequate levels, 62.5% presented moderate levels and 12.5% presented adequate levels of micronutrient supplementation. Conclusions. The abandonment of micronutrient supplementation is associated with the general factors of the infant, such as age, sex, and number of children, type of insurance and number of micronutrients and also depend on the factors related to the caregiver such as age of the caregiver, education level, marital status, number of children, origin and occupation, as shown by the Chi-square test of independence and p< 0.05, and it is established that the general factors of the child and the factors related to the caregiver are associated in the supplementation of micronutrients.

A anemia é um dos mais importantes problemas de saúde pública, com um aumento constante nos últimos anos. Há vários fatores relacionados ao descaso com a suplementação de micronutrientes. Objetivo. Estabelecer os fatores relacionados ao abandono da suplementação de micronutrientes em crianças de 6 a 36 meses de idade que freqüentam um Centro Mãe e Criança. Materiais e métodos. A abordagem foi quantitativa, básica e não-experimental, de corte transversal. A população consistia de 120 pacientes neonatais e a amostra consistia de 80 pacientes neonatais do Centro Materno e Infantil, escolhidos por amostragem não-probabilística, utilizando a técnica de pesquisa e o questionário como instrumento. Resultados. 25% apresentaram níveis inadequados, 62,5% apresentaram níveis moderados e 12,5% apresentaram níveis adequados de suplementação de micronutrientes. Conclusões. O abandono da suplementação de micronutrientes está associado aos fatores gerais da criança, tais como idade, sexo e número de crianças, tipo de seguro e número de micronutrientes e também depende dos fatores do cuidador relacionados à idade do cuidador, nível de educação, estado civil, número de crianças, origem e ocupação, como demonstrado pelo teste de independência Qui-quadrado e p< 0,05, e é estabelecido que os fatores gerais da criança e os fatores do cuidador estão associados na suplementação de micronutrientes.

Satisfacción con la vida y Conductas de salud en estudiantes universitarios de nuevo ingreso / Satisfaction with life and health behaviors in incoming college students / Satisfação com a Vida e Comportamentos de Saúde em Novos Estudantes Universitários

En la actualidad resultan escasos los estudios que relacionen la satisfacción con la vida y las conductas saludables en estudiantes que inician sus estudios universitarios, aun cuando se sabe que la transición a la etapa universitaria puede originar diversos cambios con repercusiones importantes para la salud de los estudiantes. OBJETIVO: determinar la relación entre la satisfacción con la vida y las conductas de salud en estudiantes de primer semestre de una universidad pública venezolana. MÉTODO: estudio de naturaleza cuantitativa, no experimental, descriptivo, correlacional y transversal, utilizó una muestra conformada por 636 estudiantes (65% mujeres y 35% hombres) con edades entre los 15 y 27 años, seleccionados bajo un muestreo no probabilístico intencional. RESULTADOS: los estudiantes se caracterizan por estar satisfechos con su vida y presentan niveles moderados de conductas saludables en general. Asimismo, la satisfacción con la vida difiere según el sexo y el estrato socioeconómico, mientras que algunas conductas de salud difieren según el sexo, el estrato socioeconómico y la edad. Por otra parte, la satisfacción con la vida presenta relación significativa con las conductas de salud a nivel general y en las dimensiones conductas preventivas, sueño, actividad física, control en el consumo de drogas y chequeo médico. CONCLUSIÓN: la satisfacción con la vida resulta ser una variable protectora que fomenta conductas saludables en estudiantes universitarios, en especial los que recién inician los estudios, siendo importante considerarla en futuras intervenciones y programas de promoción de la salud.

Currently, there are few studies that relate satisfaction with life and healthy behaviors in students starting their university studies, even though it is known that the transition to the university stage can cause various changes with important repercussions on the health of students. OBJECTIVE: to determine the relationship between life satisfaction and health behaviors in first semester students at a Venezuelan public university. METHOD: a quantitative, non-experimental, descriptive, correlational, and cross-sectional study, using a sample of 636 students (65% women and 35% men) between 15 and 27 years of age, selected under a non-probabilistic intentional sampling. RESULTS: the students are characterized by being satisfied with their lives and present moderate levels of healthy behaviors in general. Also, life satisfaction differs by gender and socioeconomic status, while some health behaviors differ by gender, socioeconomic status, and age. On the other hand, life satisfaction is significantly related to health behaviors at the general level and in the dimension's preventive behaviors, sleep, physical activity, drug use control and medical check-up. CONCLUSION: life satisfaction turns out to be a protective variable that promotes healthy behaviors in university students, especially those who are just starting their studies, and it is important to consider it in future interventions and health promotion programs.

Atualmente, há poucos estudos que relacionam a satisfação com a vida e comportamentos saudáveis em estudantes que iniciam seus estudos universitários, embora se saiba que a transição para a etapa universitária pode causar diversas mudanças com repercussões importantes para a saúde dos alunos. OBJETIVO: determinar a relação entre satisfação com a vida e comportamentos de saúde em alunos do primeiro semestre de uma universidade pública venezuelana. MÉTODO: um estudo quantitativo, não experimental, descritivo, correlacional e transversal utilizou uma amostra de 636 estudantes (65% mulheres e 35% homens) com idade entre 15 e 27 anos, selecionados em amostragem não probabilística intencional. RESULTADOS: os alunos se caracterizam por estarem satisfeitos com suas vidas e apresentam níveis moderados de comportamentos saudáveis em geral. Além disso, a satisfação com a vida difere por sexo e status socioeconômico, enquanto alguns comportamentos de saúde diferem por sexo, estrato socioeconômico e idade. Por outro lado, a satisfação com a vida apresenta uma relação significativa com os comportamentos de saúde em nível geral e nas dimensões comportamentos preventivos, sono, atividade física, controle no uso de drogas e check-up médico. CONCLUSÃO: a satisfação com a vida acaba por ser uma variável protetora que incentiva comportamentos saudáveis em estudantes universitários, especialmente aqueles que estão apenas iniciando seus estudos, e é importante considerá-lo em intervenções futuras e programas de promoção da saúde.