Laparoscopic necrosectomy for acute necrotizing pancreatitis.

Severe acute pancreatitis (SAP), a disease state that is often complicated by an intricate pathologic process, has remained difficult to manage and is associated with high morbidity and mortality rates. Approximately 80% of patients have a mild form of the disease, while the other 20% develop a severe life-threatening form of the disease. These patients are at great risk for infection, multisystem organ failure, and, possibly, death. Necrotizing or infected pancreatitis requires a multimodal approach and often offers an indication for surgical intervention. The retroperitoneum of the patient with necrotizing pancreatitis should be treated as an abscess cavity, and drainage and debridement of all necrotic tissue should be performed. Over the past several decades, great achievements have been made in the treatment of the patient that presents with acute pancreatitis. However, the morbidity and mortality have remained high, according to recent literature. The laparoscopic era brings new alternatives in the surgical management of pancreatic diseases. Advances in laparoscopic technology and instrumentation allow the utilization of minimally invasive techniques, and lessen the stress of surgery in the already compromised pancreatitic patient.

Hepatic outflow occlusion in laparoscopic hepatectomy.

BACKGROUND: The application of laparoscopic techniques to major hepatic resection has been limited by the risk of hepatic vein laceration leading to massive bleeding or gas embolism. A balloon catheter has therefore been designed to occlude hepatic vein flow during experimental laparoscopic hepatectomy. METHODS: The procedure was attempted in 8 pigs weighing around 50 kg and submitted to laparoscopic left hemihepatectomy. A specially designed balloon catheter was inserted via the femoral vein and advanced into the retrohepatic segment of inferior vena cava (IVC). After inflation of the balloon with 17 ml contrast, angiography confirmed complete occlusion of this segment, while a central rigid channel allowed passage of blood from IVC to right atrium. Haemodynamic studies were performed during resection of the left and left paramedial lobes of the liver, which was completed laparoscopically using ultrasonic coagulating shears and vascular linear staplers. RESULTS: Inflation of the balloon reduced mean arterial pressure to 75-79% and central venous pressure to 29-42% of baseline values, while cardiac output also fell (to 69-73% of basal). IVC blood flow decreased to 58% and hepatic venous flow to only 16% of pre-inflation values. Left hemihepatectomy was successfully achieved by the laparoscopic route in all 8 animals with a mean balloon inflation time of 30 min and blood loss of 166 ml. Haemodynamic indices returned to normal after deflation of the balloon at the end of the resection. DISCUSSION: This preliminary study shows that hepatic venous outflow can be occluded by this special balloon catheter and that animals can tolerate the associated haemodynamic disturbance. Similar techniques in man might permit major hepatectomy to be safely achieved by a laparoscopic approach.

Endoscopic endocrine neck surgery with carbon dioxide insufflation: the effect on intracranial pressure in a large animal model.

BACKGROUND: Endoscopic endocrine neck surgery requires insufflation with carbon dioxide (CO(2)) at 10 to 15 mm Hg, which may decrease the cerebral venous return and increase intracranial pressure. This study evaluated the effect of CO(2) neck insufflation on intracranial pressure (ICP) and hemodynamic parameters. METHODS: Fifteen pigs underwent endoscopic thyroid dissection. Insufflation was performed with CO(2) at 0 (sham), 10, 15, and 20 mm Hg and with helium at 20 mm Hg with 3 pigs in each group. ICP, mean arterial pressure, central venous pressure (CVP), cardiac output, and blood gas were measured at baseline, 30, 60, and 120 minutes. RESULTS: There were no differences in mean ICP between the sham group and CO(2) insufflation at 10 mm Hg. Mean ICP increased significantly with CO(2) at 15 and 20 mm Hg and with helium at 20 mm Hg. A significant increase in CVP occurred in pigs operated with CO(2) at 20 mm Hg. We observed jugular vein collapse under all insufflation pressures; however, pigs operated at 10 mm Hg were able to maintain an intermittent blood flow. CONCLUSIONS: A severe increase in ICP occurs with insufflation pressures higher than 15 mm Hg, possibly as a result of decreased cervical venous blood flow. Carbon dioxide insufflation up to 10 mm Hg does not alter ICP and is recommended for clinical application in endoscopic neck surgery.

Review and case report of idiopathic lower extremity compartment syndrome and its treatment in diabetic patients.

Diabetic muscle infarction is a rare complication of diabetes mellitus. However, idiopathic compartment syndrome in the diabetic patient is even a rarer disease, which has been reported only in three cases up to date. The disease seems to occur in patients affected by type 1 diabetes mellitus with a history of poorly controlled glucose levels. MRI aids in the diagnosis by delineating the edema of the muscle. However, definitive diagnosis is made using the Stryker needle unit. Treatment is accomplished by immediate two-incision fasciotomy. We present a case where a 34 yr-old female with a long standing history of poorly controlled Type 1 diabetes mellitus presented with a painful right lower extremity and was diagnosed with compartment syndrome. In our patient, a single incision fasciotomy to release the pressure was sufficient and might be considered as an alternative and less morbid procedure in the diabetic patient with already poorly healing tissues. We conclude that the muscle infarction in these patients is from diffuse microangiopathic disease leading to muscular infarction and fluid accumulation in the cells causing a decrease in the space in the compartment in question causing compartment syndrome.

Five generations with steatocystoma multiplex congenita: a treatment regimen.

We present our treatment regimen of modified excisions for cysts of steatocystoma multiplex congenita in seven members of a family afflicted with this disease spread over five generations. The family's disease is restricted to the head and neck region. A review of the literature of this rare disease is included, and our method of treatment is described.