Nitrogen dioxide as proxy indicator of air pollution from fossil fuel burning in New Delhi during lockdown phases of COVID-19 pandemic period: impact on weather as revealed by Sentinel-5 precursor (5p) spectrometer sensor.

There has been a long-lasting impact of the lockdown imposed due to COVID-19 on several fronts. One such front is climate which has seen several implications. The consequences of climate change owing to this lockdown need to be explored taking into consideration various climatic indicators. Further impact on a local and global level would help the policymakers in drafting effective rules for handling challenges of climate change. For in-depth understanding, a temporal study is being conducted in a phased manner in the New Delhi region taking NO2 concentration and utilizing statistical methods to elaborate the quality of air during the lockdown and compared with a pre-lockdown period. In situ mean values of the NO2 concentration were taken for four different dates, viz. 4th February, 4th March, 4th April, and 25th April 2020. These concentrations were then compared with the Sentinel (5p) data across 36 locations in New Delhi which are found to be promising. The results indicated that the air quality has been improved maximum in Eastern Delhi and the NO2 concentrations were reduced by one-fourth than the pre-lockdown period, and thus, reduced activities due to lockdown have had a significant impact. The result also indicates the preciseness of Sentinel (5p) for NO2 concentrations.

Model-based ensembles: Lessons learned from retrospective analysis of COVID-19 infection forecasts across 10 countries.

Mathematical models of different types and data intensities are highly used by researchers, epidemiologists, and national authorities to explore the inherently unpredictable progression of COVID-19, including the effects of different non-pharmaceutical interventions. Regardless of model complexity, forecasts of future COVID-19 infections, deaths and hospitalization are associated with large uncertainties, and critically depend on the quality of the training data, and in particular how well the recorded national or regional numbers of infections, deaths and recoveries reflect the the actual situation. In turn, this depends on, e.g., local test and abatement strategies, treatment capacities and available technologies. Other influencing factors including temperature and humidity, which are suggested by several authors to affect the spread of COVID-19 in some countries, are generally only considered by the most complex models and further serve to inflate the uncertainty. Here we use comparative and retrospective analyses to illuminate the aggregated effect of these systematic biases on ensemble-based model forecasts. We compare the actual progression of active infections across ten of the most affected countries in the world until late November 2020 with "re-forecasts" produced by two of the most commonly used model types: (i) a compartment-type, susceptible-infected-removed (SIR) model; and (ii) a statistical (Holt-Winters) time series model. We specifically examine the sensitivity of the model parameters, estimated systematically from different subsets of the data and thereby different time windows, to illustrate the associated implications for short- to medium-term forecasting and for probabilistic projections based on (single) model ensembles as inspired by, e.g., weather forecasting and climate research. Our findings portray considerable variations in forecasting skill in between the ten countries and demonstrate that individual model predictions are highly sensitive to parameter assumptions. Significant skill is generally only confirmed for short-term forecasts (up to a few weeks) with some variation across locations and periods.

Short-Term Statistical Forecasts of COVID-19 Infections in India.

COVID-19 cases in India have been steadily increasing since January 30, 2020 and have led to a government-imposed lockdown across the country to curtail community transmission with significant impacts on societal systems. Forecasts using mathematical-epidemiological models have played and continue to play an important role in assessing the probability of COVID-19 infection under specific conditions and are urgently needed to prepare health systems for coping with this pandemic. In many instances, however, access to dedicated and updated information, in particular at regional administrative levels, is surprisingly scarce considering its evident importance and provides a hindrance for the implementation of sustainable coping strategies. Here we demonstrate the performance of an easily transferable statistical model based on the classic Holt-Winters method as means of providing COVID-19 forecasts for India at different administrative levels. Based on daily time series of accumulated infections, active infections and deaths, we use our statistical model to provide 48-days forecasts (28 September to 15 November 2020) of these quantities in India, assuming little or no change in national coping strategies. Using these results alongside a complementary SIR model, we find that one-third of the Indian population could eventually be infected by COVID-19, and that a complete recovery from COVID-19 will happen only after an estimated 450 days from January 2020. Further, our SIR model suggests that the pandemic is likely to peak in India during the first week of November 2020.

A clinical study on the Naimittika Rasayana effect of Silajatu and Mamajjaka in type-2 Diabetes Mellitus.

BACKGROUND: Recent years have shown an alarming rise in the incidence of diabetes mellitus (DM) all over the world. The present management of DM it not satisfactory. Hence, alternative systems of medicine are also being explored. Prameha as described in Ayurveda is a disease synonymous with today's DM. The patients of Prameha inherently carry the risk of impaired Agni and depleted Ojas status, that is, hypometabolic and immuno-compromised state. Now the primary goal is not merely to achieve normoglycemia, but also to minimize its complications. In this context, many Ayurvedic drugs are undergoing extensive research. AIM: To evaluate the anti-diabetic, immune-enhancer and biofire balancing effects of Naimittika Rasayana drugs viz. Silajatu and Mamajjaka in type-2 DM. MATERIALS AND METHODS: A total of 95 patients of type-2 DM were registered; in which 84 patients turned up for full follow-up. Patients were randomly allocated into three groups; Group-A was treated with Mamajjaka (500mg twice a day) and Group-B with Silajatu (500mg twice a day) and Group-C was treated with modern drug and assessment was done at monthly intervals for three months. RESULTS: The selected Rasayana drugs have shown good response on subjective and objective parameters. The Mamajjaka treated patients responded better. However, as regards the reduction of post prandial blood sugar, Silajatu was superior. CONCLUSION: The Ayurveda-inspired holistic approach seems to have a unique response promoting Agni (biofire) and Ojas (immune strength) status leading to good health and wellness.