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NeuroRehabilitation ; 54(3): 359-371, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38393927

RESUMEN

BACKGROUND: Multiple Organ failure (MOF) is one of the main causes of admission to the Intensive Care Unit (ICU) of patients infected with COVID-19 and can cause short- and long-term neurological deficits. OBJECTIVE: To compare the cognitive functioning and functional brain connectivity at 6-12 months after discharge in two groups of individuals with MOF, one due to COVID-19 and the other due to another cause (MOF-group), with a group of Healthy Controls (HC). METHODS: Thirty-six participants, 12 from each group, underwent a neuropsychological and neuroimaging assessment at both time-points. Functional connectivity of the resting state networks was compared between COVID-19 and HC while controlling for the effect of MOF. The association between functional connectivity and neuropsychological performance was also investigated. RESULTS: Compared to the HC, COVID-19 group demonstrated hypoconnectivity between the Default Mode Network and Salience Network. This pattern was associated with worse performance on tests of attention and information processing speed, at both time-points. CONCLUSION: The study of the association between cognitive function and brain functional connectivity in COVID-19 allows the understanding of the short- and long-term neurological alterations of this disease and promotes the development of intervention programs to improve the quality of life for this understudied population.


Asunto(s)
Encéfalo , COVID-19 , Enfermedad Crítica , Imagen por Resonancia Magnética , Humanos , COVID-19/diagnóstico por imagen , COVID-19/fisiopatología , Masculino , Femenino , Persona de Mediana Edad , Encéfalo/diagnóstico por imagen , Encéfalo/fisiopatología , Anciano , Cognición/fisiología , Pruebas Neuropsicológicas , Adulto , Insuficiencia Multiorgánica/fisiopatología , Insuficiencia Multiorgánica/etiología , Insuficiencia Multiorgánica/diagnóstico por imagen , Red Nerviosa/diagnóstico por imagen , Red Nerviosa/fisiopatología , Conectoma
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