RESUMEN
A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6+43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation.
Asunto(s)
Anticuerpos Monoclonales/sangre , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Linfoma no Hodgkin/sangre , Linfoma no Hodgkin/diagnóstico , Trastornos Linfoproliferativos/sangre , Trastornos Linfoproliferativos/diagnóstico , Masculino , Policitemia Vera/sangre , Policitemia Vera/diagnóstico , Macroglobulinemia de Waldenström/sangre , Macroglobulinemia de Waldenström/diagnósticoRESUMEN
A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immunofixation. Of the 1214 patients with monoclonal gammopathies, 49 had a double MC but only 34 (2.8%) were included in our study. A double MC was associated with hematological malignancies in 20/34 cases. Based on our experience, a double MC is more often associated with other diseases, especially an oncohematological one.