Acroosteólisis y dismorfia facial: un nuevo caso de síndrome de Hajdu-Cheney / Acroosteolysis and facial dysmorphia: a new case of Hajdu-Cheney Syndrome

El síndrome de Hajdu-Cheney o síndrome acro-dento-osteo-displasia es una enfermedad rara caracterizada por osteólisis en banda de las falanges distales y dismorfia facial, entre otras manifestaciones. Describimos el caso de un varón de 45 años que consultó por dolor articular de características mecánicas en las manos, asociando dismorfia facial, alteraciones craneofaciales y deformidades digitales en telescopaje con acroosteólisis.(AU)

Hajdu-Cheney syndrome or acro-dento-osteo-dysplasia syndrome is a rare disease characterized by band osteolysis of distal phalanges and facial dysmorphia, among other manifestations. We present the case of a 45-year-old male who consulted for mechanical joint pain of both hands, facial dysmorphism, cranio-facial alterations, and digital telescoping with acroosteolysis.(AU)

Acroosteolysis and facial dysmorphia: a new case of Hajdu-Cheney syndrome.

Hajdu-Cheney syndrome or acro-dento-osteo-dysplasia syndrome is a rare disease characterized by band osteolysis of distal phalanges and facial dysmorphia, among other manifestations. We present the case of a 45-year-old male who consulted for mechanical joint pain of both hands, facial dysmorphism, cranio-facial alterations, and digital telescoping with acroosteolysis.

Artritis psoriásica: interacción entre enfermedades cardiometabólicas y la actividad inflamatoria de la enfermedad / Psoriatic arthritis: interaction between cardiometabolic diseases and inflammatory burden of the disease

Antecedentes y objetivos: La artritis psoriásica se acompaña de una serie de comorbilidades cardiovasculares y metabólicas. La obesidad transcribe un estado de inflamación sistémica de bajo grado. Además, es un predictor negativo de la respuesta al tratamiento. Nuestro objetivo es evaluar si existen interacciones entre el estado metabólico, los parámetros inflamatorios y la actividad de la enfermedad. También queremos comprobar si las enfermedades metabólicas o cardiovasculares tienen alguna asociación con la reducción de la carga inflamatoria mediante el tratamiento de la enfermedad. Material y método: Hemos realizado un estudio descriptivo transversal de 160 pacientes con artritis psoriásica. Se recogieron variables sociodemográficas, clínicas y analíticas. También se registró la presencia de dactilitis y entesitis, el HAQ, DAPSA y si se cumplen o no los criterios MDA. La prueba de chi-cuadrado y la H de Kruskall Wallis se utilizaron para realizar comparaciones, considerando p<0,05 como estadísticamente significativo. Para establecer correlaciones, se utilizó el coeficiente de correlación de Pearson. Resultados: El IMC y el perímetro abdominal se correlacionan con la PCR y la VSG (significación<0,05) aunque la fuerza de correlación es baja (Pearson<0,4), pero no con DAPSA o con cumplir los criterios de MDA. El uso de terapias biológicas se asocia con una menor prevalencia de eventos cardiovasculares (p=0,047; OR: 0,12; IC 95%: 0,01-0,9) y de entesitis (p=0,008; OR: 0,3; IC 95%: 0,16-0,56). También se asocia a unos niveles normales de PCR (p=0,029; OR: 0,25; IC 95%: 0,07-0,87) y VSG (p=0,024; OR: 0,36; IC 95%: 0,16-0,82) cuando se compara con las terapias convencionales. Discusión y conclusiones: El tratamiento anti-TNFα podría reducir el riesgo cardiovascular en pacientes con artritis psoriásica. Puede haber niveles más altos de PCR y VSG en personas obesas sin que esto implique necesariamente una mayor actividad de la enfermedad.(AU)

Background and objetives: Psoriatic arthritis is accompained by several cardiometabolic comorbidities. Obesity causes a low-grade systemic inflammation and is a negative predictor of treatment response. We wanted to evaluate if there are interactions between metabolic status, inflammatory parameters and disease activity; and whether metabolic or cardiovascular diseases have any association with the reduction of the inflammatory burden by treating the psoriatic arthritis. Material and methods: We have carried out a cross-sectional descriptive study of 160 patients with psoriatic arthritis. Sociodemographic, clinical and analytical variables were collected, as well as the presence of dactylitis and enthesitis; and HAQ, DAPSA and Minimal Disease Activity criteria. Chi-square test and the H of Kruskall Wallis were used to carry out comparisons, considering P<.05 as statistically significant. To establish correlations, Pearson correlation coefficient was used. Results: BMI and waist circumference correlate with CRP and ESR (significance: <.05) although the correlation strenght is low (Pearson<.4), but there is no such relationship with DAPSA or meeting MDA criteria. Using biologic therapies is associated with a lower prevalence of cardiovascular events (P=0.047; OR: 0.12, 95% CI: 0.01-0.9) and enthesitis (P=.008; OR: 0.3, CI 95%: 0.16-0.56); and normal levels of CRP (P=.029; OR: 0.25, 95% CI: 0.07-0.87) and ESR (P=0.024; OR: 0.36, 95% CI: 0.16-0.82) when comparing to conventional therapies. Discussion and conclusions: Anti-TNFα treatment could reduce cardiovascular risk in patients with psoriatic arthritis. There may be higher levels of CRP and ESR in obese individuals without this necessarily implying higher disease activity.(AU)

Psoriatic arthritis: interaction between cardiometabolic diseases and inflammatory burden of the disease.

BACKGROUND AND OBJETIVES: Psoriatic arthritis is accompained by several cardiometabolic comorbidities. Obesity causes a low-grade systemic inflammation and is a negative predictor of treatment response. We wanted to evaluate if there are interactions between metabolic status, inflammatory parameters and disease activity; and whether metabolic or cardiovascular diseases have any association with the reduction of the inflammatory burden by treating the psoriatic arthritis. MATERIAL AND METHODS: We have carried out a cross-sectional descriptive study of 160 patients with psoriatic arthritis. Sociodemographic, clinical and analytical variables were collected, as well as the presence of dactylitis and enthesitis; and HAQ, DAPSA and Minimal Disease Activity criteria. Chi-square test and the H of Kruskall Wallis were used to carry out comparisons, considering P < .05 as statistically significant. To establish correlations, Pearson correlation coefficient was used. RESULTS: BMI and waist circumference correlate with CRP and ESR (significance: < .05) although the correlation strenght is low (Pearson <.4), but there is no such relationship with DAPSA or meeting MDA criteria. Using biologic therapies is associated with a lower prevalence of cardiovascular events (P = 0.047; OR: 0.12, 95% CI: 0.01-0.9) and enthesitis (P = .008; OR: 0.3, CI 95%: 0.16-0.56); and normal levels of CRP (P = .029; OR: 0.25, 95% CI: 0.07-0.87) and ESR (P = 0.024; OR: 0.36, 95% CI: 0.16-0.82) when comparing to conventional therapies. DISCUSSION AND CONCLUSIONS: Anti-TNFα treatment could reduce cardiovascular risk in patients with psoriatic arthritis. There may be higher levels of CRP and ESR in obese individuals without this necessarily implying higher disease activity.

Psoriatic arthritis: interaction between cardiometabolic diseases and inflammatory burden of the disease. / Artritis psoriásica: interacción entre enfermedades cardiometabólicas y la actividad inflamatoria de la enfermedad.

BACKGROUND AND OBJETIVES: Psoriatic arthritis is accompained by several cardiometabolic comorbidities. Obesity causes a low-grade systemic inflammation and is a negative predictor of treatment response. We wanted to evaluate if there are interactions between metabolic status, inflammatory parameters and disease activity; and whether metabolic or cardiovascular diseases have any association with the reduction of the inflammatory burden by treating the psoriatic arthritis. MATERIAL AND METHODS: We have carried out a cross-sectional descriptive study of 160 patients with psoriatic arthritis. Sociodemographic, clinical and analytical variables were collected, as well as the presence of dactylitis and enthesitis; and HAQ, DAPSA and Minimal Disease Activity criteria. Chi-square test and the H of Kruskall Wallis were used to carry out comparisons, considering P<.05 as statistically significant. To establish correlations, Pearson correlation coefficient was used. RESULTS: BMI and waist circumference correlate with CRP and ESR (significance: <.05) although the correlation strenght is low (Pearson<.4), but there is no such relationship with DAPSA or meeting MDA criteria. Using biologic therapies is associated with a lower prevalence of cardiovascular events (P=0.047; OR: 0.12, 95% CI: 0.01-0.9) and enthesitis (P=.008; OR: 0.3, CI 95%: 0.16-0.56); and normal levels of CRP (P=.029; OR: 0.25, 95% CI: 0.07-0.87) and ESR (P=0.024; OR: 0.36, 95% CI: 0.16-0.82) when comparing to conventional therapies. DISCUSSION AND CONCLUSIONS: Anti-TNFα treatment could reduce cardiovascular risk in patients with psoriatic arthritis. There may be higher levels of CRP and ESR in obese individuals without this necessarily implying higher disease activity.