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1.
Front Plant Sci ; 15: 1359783, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38571710

RESUMEN

The phenology has gained considerably more attention in recent times of climate change. The transition from vegetative to reproductive phases is a critical process in the life history of plants, closely tied to phenology. In an era of climate change, understanding how environmental factors affect this transition is of paramount importance. This study consisted of field surveys and a greenhouse experiment on the reproductive biology of Northern pipevine (Aristolochia contorta Bunge). During field surveys, we investigated the environmental factors and growth characteristics of mature A. contorta, with a focus on both its vegetative and reproductive phases. In its successful flowering during the reproductive phase, A. contorta grew under the conditions of 40% relative light intensity and 24% soil moisture content, and had a vertical rhizome. In the greenhouse experiments, we examined the impact of increased CO2 concentration on the growth and development of 10-year-old A. contorta, considering the effect of rhizome direction. Planted with a vertical rhizome direction, A. contorta exhibited sufficient growth for flowering under ambient CO2 concentrations. In contrast, when planted with a horizontal rhizome direction, it was noted to significantly impede successful growth and flowering under elevated CO2 concentrations. This hindered the process of flowering, highlighting the pivotal role of substantial vegetative growth in achieving successful flowering. Furthermore, we observed a higher number of underground buds and shoots under the conditions of elevated CO2 concentration and a horizontal rhizome direction instead of flowering. Elevated CO2 concentrations also exhibited diverse effects on mature A. contorta's flower traits, resulting in smaller flower size, shorter longevity, and reduced stigma receptivity, and pollen viability. The study shed light on elevated CO2 concentrations can hinder growth, potentially obstructing sexual reproduction and diminishing genetic diversity.

2.
Heliyon ; 10(2): e24497, 2024 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-38298666

RESUMEN

In this study, to address the stability issues, we synthesized a CsPbBr3-coated poly (maleic anhydride-alt-1-octadecene) (CsPbBr3/PMA) using a modified hot-injection method. The CsPbBr3/PMA perovskite nanocrystals (PNCs) exhibited effective green emission at 522 nm with an improved photoluminescence quantum yield (86.8 %) compared to traditional CsPbBr3 PNCs (54.2 %). The ligands in the polymer coating can bond with the uncoordinated Pb and Br ions on the surface of PNCs to minimize surface defects and avoid exposure to the external environment, enhancing the stability of the perovskites. Time-resolved photoluminescence spectra showed longer lifetimes for CsPbBr3/PMA PNCs, while transient absorption measurements provided valuable insights into the intraband hot-exciton relaxation and recombination. We demonstrate the potential application of CSPbBr3/PMA in a down-conversion white-light-emitting diode (LED) by coupling green CsPbBr3/PMA and red K2SiF6:Mn4+ phosphor-coated glass slides onto a 455-nm blue GaN LED. The white LED produced a white light with the International Commission on Illumination color coordinates of (0.323, 0.345), luminous efficiency of 58.4 lm/W, and color rendering index of 83.2. The fabricated, white-LED system obtained a wide color gamut of 125.3 % of the National Television Standards Committee and 98.9 % of Rec. 2020. The findings demonstrate that CsPbBr3/PMA can be an efficient down-conversion material for white LEDs and backlighting.

3.
J Interpers Violence ; 39(13-14): 2959-2980, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38243761

RESUMEN

Bystanders play a crucial role in assisting and rescuing victims of intimate partner violence (IPV) or sexual assault, thereby preventing further harm. Consequently, an increasing amount of research has focused on improving bystander interventions in such situations. While many existing scales that measure bystanders' willingness to intervene and their behaviors are likely tailored to Western settings and primarily focused on preventing sexual assaults, pursuing diversity to make these scales applicable to a variety of contexts is necessary. This study aimed to develop and validate a scale from South Korean samples that measure the likely level of bystander engagement in witnessed IPV situations, named the Bystander Engagement Scale for Witnessed Intimate Partner Violence (BESW-IPV). Preliminary items, developed to describe various IPV situations that a bystander might witness, underwent content validity testing through expert review and cognitive focus group interviews. Afterward, the scale was administered to 311 participants from the target population in South Korea. The scale's factor structure was assessed through exploratory factor analysis (EFA) and confirmed through confirmatory factor analysis (CFA). The reliability and validity were rigorously assessed. The final version of the BESW-IPV comprised 28 items. Through EFA, "direct IPV indicators" and "indirect IPV indicators" were identified. Together, these factors accounted for 76.10% of the total variance. CFA affirmed that the final model offers an acceptable fit. The scale's convergent and discriminant validities were also well established. The Cronbach's alpha and the McDonald's omega values were 0.98 and 0.99, respectively. In contrast to many existing tools that measure bystander intervention predominantly within the confines of Western educational settings, we believe that the BESW-IPV can be applied in broader contexts, especially in patriarchal environments. Further research is required to translate and validate this tool in different cultural contexts.


Asunto(s)
Violencia de Pareja , Humanos , República de Corea , Violencia de Pareja/psicología , Violencia de Pareja/prevención & control , Femenino , Masculino , Adulto , Reproducibilidad de los Resultados , Adulto Joven , Encuestas y Cuestionarios , Persona de Mediana Edad , Psicometría
4.
Arch Psychiatr Nurs ; 46: 59-64, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-37813505

RESUMEN

PURPOSE: This study examines the impact of problematic smartphone use (PSU) on children aged six years and younger, as perceived by their main caregivers. METHOD: Overall, 15 mothers who identified that their children used smartphones excessively were recruited and interviewed. Data were analyzed using summative content analysis. FINDINGS: Participants reported various impacts of PSU that were categorized into developmental, behavioral, health, quality of life, and parent-child relational perspectives. PRACTICAL IMPLICATIONS: Efforts to prevent PSU in children are needed. Nurses' roles in the early assessment of PSU are essential.


Asunto(s)
Conducta Adictiva , Teléfono Inteligente , Femenino , Humanos , Calidad de Vida , Cuidadores , Madres
5.
Trauma Violence Abuse ; : 15248380231204887, 2023 Oct 30.
Artículo en Inglés | MEDLINE | ID: mdl-37902582

RESUMEN

Gender-based violence (GBV) is a pervasive public health issue that harms victims. Bystanders' interventions are crucial in preventing the risks of GBV; however, numerous barriers impede their willingness and behaviors to intervene. As a part of efforts to thwart these barriers, this study used a systematic review and meta-analysis to identify such barriers and assess their impact on bystanders' engagement to intervene. The researchers explored academic databases and included 38 studies in the analysis; we extracted and coded the identified barriers (e.g., lack of responsibility, rape myth) and allocated them to six domains: failure to notice, failure to perceive risk, failure to take responsibility for engaging, lack of bystander efficacy/competency, failure to take an action, and failure of previous intervention attempts. We calculated the overall and domain-specific effect sizes (ES) and performed moderator analysis. The overall ES of the barriers identified in the review were small but statistically significant. The most potent bystander intervention barrier domain was failed previous intervention attempts; the greatest specific barriers therein were negative emotions and feelings of uncertainty after engaging in bystander behaviors. University/college populations were more vulnerable to barriers to intervention than community members. Moreover, the barriers were more prohibitive in incidents of violence against women and sexual assaults than in intimate partner violence. Bystander-focused programs that address negative emotions and feelings arising from prior intervention experiences are needed to foster continued bystander engagement and assistance in GBV; moreover, tailored program content should also be provided for groups most vulnerable to intervention barriers.

6.
Front Plant Sci ; 14: 1226331, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37810400

RESUMEN

Insects are vital pollinators for angiosperms, playing a crucial role in their reproductive success and fruit production. Aristolochia contorta is a perennial herbaceous vine that occurs in fragmented populations across East Asia. One notable feature of this plant is its trap flower, which employs a unique mechanism to attract, trap, retain, and release insects, ensuring effective pollination. The presence of this trap flower significantly influences the pollination system of A. contorta. Field surveys and pollination experiments were conducted to understand the processes and effectiveness of its pollination mechanism. It was allogamous and was pollinated by the species from Ceratopogonidae. During the insect attraction stage, 11.57% of the flowers contained insects, primarily Ceratopogonidae spp. Most Ceratopogonidae spp. concentrated in few flowers, indicating that although overall attraction might be modest, specific flowers acted as significant focal points for gathering. Trichomes effectively trapped Ceratopogonidae spp. inside flower tubes. In the retention stage, 26.16% of Ceratopogonidae spp. were loaded with pollen grains, but only 7.91% of those exited the flowers in the release stage. The sticky texture of the perianth's internal cavity posed challenges during this release, leading to adhesion and clogging of the narrow perianth tube. Consequently, a significant portion of Ceratopogonidae spp. became trapped on the perianth wall and perished. This highlights that despite the significant energy and resources invested in flower development, the perianth contributes to the low pollination effectiveness. This study revealed additive factors with negative effects on pollination, including the densely clustered distribution of its pollinators within only a few flowers, insufficient pollen loading onto pollinators, hindered release of entrapped pollinators due to the perianth adhesive surface, and a high rate of defective pollen grains in A. contorta. These factors account for the observed phenomenon of low fruit set (7.7%) and contribute to the diminished rate of sexual reproduction in A. contorta populations. This might lead the species to heavily rely on asexual reproduction, which could potentially lead to gene erosion within populations. The implications of these findings extend to the ecological and conservation aspects, emphasizing the need to understand and conserve the unique pollination system of A. contorta.

7.
Food Sci Anim Resour ; 43(5): 914-937, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37701750

RESUMEN

The objective of this study was to establish a multi-residue quantitative method for the analysis of anthelmintic and antiprotozoal drugs in various livestock products (beef, pork, and chicken) using ultra-high-performance liquid chromatography-tandem mass spectrometry. Each compound performed validation at three different levels i.e., 0.5, 1, and 2× the maximum residue limit according to the CODEX guidelines (CAC/GL 71-2009). This study was conducted according to the modified quick, easy, cheap, effective, rugged, and safe procedure. The matrix-matched calibrations gave correlation coefficients >0.98, and the obtained recoveries were in the range of 60.2%-119.9%, with coefficients of variation ≤32.0%. Furthermore, the detection and quantification limits of the method were in the ranges of 0.03-3.2 and 0.1-9.7 µg/kg, respectively. Moreover, a survey of residual anthelmintic and antiprotozoal drugs was also carried out in 30 samples of beef, pork, and chicken collected in Korea. Toltrazuril sulfone was detected in all three samples. Thus, our results indicated that the developed method is suitable for determining the anthelmintic and antiprotozoal drug contents in livestock products.

8.
Int J Ment Health Nurs ; 32(6): 1598-1615, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37553813

RESUMEN

The family is the primary caregiver for most patients with schizophrenia, and their roles are essential in patients' illness trajectories and outcomes. Due to this, various family interventions for schizophrenia have been developed and applied to the relatives who take care of their family members with schizophrenia. This study examined the effectiveness of existing family interventions for schizophrenia in achieving their target outcomes at both the family and patient levels by utilizing a systematic review and meta-analysis. Combinations of terms were used to search for relevant studies from the databases. Thirty-seven randomized controlled trials that met the inclusion criteria were included in the analysis. Based on the pooled result of the included studies, the programmes significantly improved the targeted outcomes with large effect size. The programmes' impacts on family-related outcomes were higher than those on patients. Among the targeted outcomes, patients' treatment satisfaction and adherence and family caregivers' mental health were the most remarkable outcomes that had improved from the included programmes. Conversely, outcomes related to family relationships, caregiving experiences, perceived social support of family caregivers, and patients' medication use did not see significant improvements. The programmes delivered to individual family units and only to the family caregivers were more effective than those delivered to groups of caregivers and caregivers and patients together, respectively. Programme-focused interventions were more effective than emotion-focused ones. Based on these findings, an in-home visiting nurse programme or advanced technology is suggested when applying family interventions for schizophrenia in practice.


Asunto(s)
Esquizofrenia , Humanos , Esquizofrenia/terapia , Apoyo Social , Familia/psicología , Pacientes , Emociones , Cuidadores/psicología
9.
PLoS One ; 18(7): e0288246, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37450484

RESUMEN

The COVID-19 pandemic has led to substantial lifestyle changes worldwide, contributing to heightened psychological stressors such as depression and anxiety. The demands of parental care have also intensified, increasing the risk of caregiver burnout and potential child maltreatment. This study aimed to evaluate the efficacy and feasibility of implementing distance laughter therapy for mothers caring for young children during the pandemic, with a focus on mitigating depression, anxiety, and parental stress. Utilizing a pilot randomized controlled design, 22 participants were divided into two groups-experimental and control groups-and underwent four virtual sessions over two weeks. The experimental group engaged in distance laughter therapy, a technique designed to stimulate self-induced laughter, while the control group viewed a 50-minute entertainment TV show. Both groups experienced a significant decrease in depression and anxiety; however, only the experimental group experienced a significant reduction in parental stress. Nonetheless, the differences in outcomes between the groups were not statistically significant. Participants who engaged in distance laughter therapy reported positive changes across physical, emotional, social, self-perception, and stress-coping domains in exit interviews. Therefore, laughter therapy has an additional benefit of reducing parental stress, which may be particularly useful for mothers primarily responsible for childcare during the pandemic. Future research should investigate the effects of laughter on broader populations and settings and quantify the actual amount of laughter generated.


Asunto(s)
COVID-19 , Risoterapia , Femenino , Niño , Humanos , Preescolar , Madres , Proyectos Piloto , Pandemias , Depresión/terapia , Ansiedad/terapia , Estrés Psicológico/terapia
10.
Issues Ment Health Nurs ; 44(7): 602-609, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37410673

RESUMEN

This study sought to examine the association between male-to-female physical, psychological, and sexual violence and controlling behaviors of male partners. Further, the moderating effect of insecure attachment style on this association was examined in the context of South Korea. Existing national data collected from a representative Korean sample of 2,000 unmarried men was utilized. Findings indicated controlling behaviors among men were positively and negatively associated with psychological and physical violence, respectively, and no association was observed with sexual violence against female partners. Anxious attachment moderated the relationship between control over partner and psychological abuse. The avoidant attachment was identified as a quasi and pure moderator for the associations between control over the partner and physical and sexual violence, respectively.


Asunto(s)
Violencia de Pareja , Delitos Sexuales , Masculino , Humanos , Femenino , Conducta Sexual/psicología , Parejas Sexuales/psicología , Delitos Sexuales/psicología , Violencia , República de Corea , Violencia de Pareja/psicología
11.
Toxics ; 11(6)2023 Jun 12.
Artículo en Inglés | MEDLINE | ID: mdl-37368626

RESUMEN

This study aims to propose an indoor air quality prediction method that can be easily utilized and reflects temporal characteristics using indoor and outdoor input data measured near the indoor target point as input to calculate indoor PM2.5 concentration through a multiple linear regression model. The atmospheric conditions and air pollution detected in one-minute intervals using sensor-based monitoring equipment (Dust Mon, Sentry Co Ltd., Seoul, Korea) inside and outside houses from May 2019 to April 2021 were used to develop the prediction model. By dividing the multiple linear regression model into one-hour increments, we attempted to overcome the limitation of not representing the multiple linear regression model's characteristics over time and limited input variables. The multiple linear regression (MLR) model classified by time unit showed an improvement in explanatory power by up to 9% compared to the existing model, and some hourly models had an explanatory power of 0.30. These results indicated that the model needs to be subdivided by time period to more accurately predict indoor PM2.5 concentrations.

12.
Aging Ment Health ; 27(11): 2193-2201, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37132465

RESUMEN

OBJECTIVES: Elder suicide is a serious concern in many countries, including South Korea. Various policies and programs to prevent elder suicide are essential; however, further understanding of this phenomenon is necessary. The current study, therefore, developed a model for understanding the underlying mechanism of suicidal ideation in older adults in South Korea. The model was based on Andersen's theory (2021), which explains the path from social relationships to mental health. METHODS: This study was conducted utilizing meta-analytic structural equation modeling in accordance with a pooled correlation matrix. We used data from 93 existing studies systematically identified in nine academic databases. RESULTS: The fit statistics show that our model fits the data well. The results demonstrated that suicidal ideation was directly affected by abuse, depression, and self-esteem but not by family relationships. Depression significantly mediated the relationship between abuse and suicidal ideation and between family relationships and suicidal ideation. CONCLUSION: Social relationships play an important role in determining mental health among Korean older adults, consistent with Andersen's theory. Prevention of elder abuse and depression is essential in preventing suicide among older adults in South Korea.


Asunto(s)
Ideación Suicida , Suicidio , Humanos , Anciano , Depresión/epidemiología , Depresión/psicología , Salud Mental , Relaciones Interpersonales , República de Corea/epidemiología , Factores de Riesgo
13.
Sci Rep ; 13(1): 8289, 2023 05 22.
Artículo en Inglés | MEDLINE | ID: mdl-37217596

RESUMEN

Sericinus montela, a globally threatened butterfly species, feeds exclusively on Aristolochia contorta (Northern pipevine). Field surveys and glasshouse experiments were conducted to obtain a better understanding of the relationship between the two species. Interviews with the persons concerned with A. contorta were conducted to collect information about the site management measures. We found that management practices to control invasive species and manage the riverine areas might reduce the coverage of A. contorta and the number of eggs and larvae of S. montela. Our results indicated that the degraded quality of A. contorta may result in a decrease in S. montela populations by diminishing their food source and spawning sites. This study implies that ecological management in the riverine area should be set up to protect rare species and biodiversity.


Asunto(s)
Aristolochia , Mariposas Diurnas , Mariposas Nocturnas , Animales , Humanos , Larva , Actividades Humanas
14.
J Pediatr Nurs ; 72: 84-91, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37209621

RESUMEN

PURPOSE: As the age of exposure to screen media has decreased, problematic smartphone usage is becoming more prevalent among younger children. As children's smartphone use is often determined by their caregivers, understanding their motivations for allowing young children to use smartphones is crucial. This study aimed to explore the behavioral patterns of main caregivers in South Korea related to their young children's smartphone usage and the underlying motivations. DESIGN AND METHODS: Semi-structured phone interviews were conducted, audio-recorded, transcribed, and analyzed using grounded theory methodology. RESULTS: Fifteen participants from South Korea, identifying as main caregivers of young children under six years of age and expressing concerns about their children's smartphone usage patterns, were recruited. A core category describing caregiver' behaviors of managing children to use smartphones was identified as "Maintaining a vicious cycle to seek comfort in parenting." Their behavioral patterns appeared to be cyclical, alternating between permitting and restricting their children's smartphone use. They permitted their children to use smartphones to decrease their parenting burdens. However, this led to discomfort as they perceived the negative impacts of smartphones on their children and felt guilty. Consequently, they limited smartphone use, which increased their parental burden again. CONCLUSION: Parental education and policy efforts are essential to prevent risks associated with children's problematic smartphone usage. PRACTICE IMPLICATIONS: During regular health checkups for young children, nurses should assess potential smartphone overuse and related problems, considering caregiver motivations.


Asunto(s)
Cuidadores , Teléfono Inteligente , Humanos , Niño , Preescolar , Padres , Responsabilidad Parental , República de Corea
15.
J Interpers Violence ; 38(15-16): 8969-8990, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37070815

RESUMEN

Intimate partner violence (IPV) can occur when bystanders are present, and these bystanders may intervene to prevent the situation from worsening and assist the victims. Despite the importance of bystanders' roles and behaviors in relation to IPV incidents, as well as extensive research to understand and promote it, there have been relatively few studies aimed at understanding their reactions in non-Western populations. Moreover, bystanders' subjective opinions and thoughts have largely been neglected when predicting their intention to intervene. Therefore, the current study identified the types of bystanders in South Korea based on their subjective reactions when witnessing IPV incidents. Q-methodology was utilized. A Q-set comprising 31 statements describing the possible range of bystander reactions was constructed using a systematic review method. The 42 participants were asked to sort the Q-set based on their agreement and provide qualitative responses regarding the reasons behind their sorting. The data were analyzed using the PQMethod software. Consequently, three types of bystander groups were extracted based on the participants' sorting statement patterns: (1) hesitant helpers needing justification, (2) outsiders denouncing the couple, and (3) active interveners opposing the violence. Each type of bystander expressed different opinions and thoughts about bystander reactions and behaviors in IPV situations. However, participants frequently showed a willingness to intervene when they knew the victim personally and when the victim directly requested help. With our findings as a reference, we expect that various bystander programs with specified purposes will be developed to effectively increase the competency of diverse bystanders to maximize their roles in relation to IPV.


Asunto(s)
Pueblos del Este de Asia , Violencia de Pareja , Humanos , Violencia de Pareja/prevención & control , Violencia , Conducta de Ayuda , Actitud
16.
Epidemiol Health ; 45: e2023015, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36731472

RESUMEN

OBJECTIVES: This study was to examine the changes in dietary habits and food and nutrient intakes between before (2019) and during (2020) the coronavirus disease 2019 (COVID-19) pandemic from the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: A total of 54,995 participants aged ≥19 years who participated in the 2011-2020 KNHANES were included. The 10-year trend (2011-2020) and differences between 2019 and 2020 for dietary habits and food and nutrient intakes were estimated using SAS. RESULTS: In the past 10 years (2011-2020), the dietary habits (increase in skipping meals and eating out), food intake (increase in meats and decrease in fruits and vegetables), and nutrient intake (increase in fat and decrease in sodium) in adults have changed. When comparing between 2019 and 2020, there were 4.6%p decrease in the eating out more than once a day. On the other hand, there were no significant differences in the intakes of food, energy and most of nutrients between 2019 and 2020, except for the proportion of energy intake from fat (1.0%p increase) and carbohydrate (1.0%p decrease). CONCLUSIONS: Although a change in dietary habits from before to during the COVID-19 pandemic was observed, food and nutrient intakes have not deteriorated markedly and appear similar to the trends in the past 10 years. Throughout the COVID-19 pandemic, it is necessary to monitor the effects of changes in dietary habits on health as well as food and nutrient intakes.


Asunto(s)
COVID-19 , Ingestión de Alimentos , Conducta Alimentaria , Pandemias , Adulto , Humanos , Dieta , Encuestas Nutricionales , República de Corea/epidemiología , Alimentos
17.
J Am Coll Health ; 71(8): 2319-2328, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-34415824

RESUMEN

The purpose of this study was to test the effectiveness and sociocultural feasibility of a dating violence (DV) bystander intervention program, called With-Us, implemented on university campus in South Korea. Participants were recruited from two universities, some as part of an intervention group (n = 99) and the others as part a comparison group (n = 67). The participants were assessed pre- and post-interventions in terms of their readiness and intention to help, as well as their efficacy. Analyses show that the program increased the readiness in bystanders to help victims. Contrarily, it was observed that older participants, males, and those having higher patriarchal gender stereotypes, were less likely to pay attention to the program. Based on the findings, we provided several suggestions to promote its effectiveness and sociocultural feasibility so that it could be efficiently applied in further studies.


Asunto(s)
Violencia de Pareja , Delitos Sexuales , Masculino , Humanos , Universidades , Mercadeo Social , Estudios de Factibilidad , Estudiantes , Violencia de Pareja/prevención & control
18.
Trauma Violence Abuse ; 24(4): 2115-2129, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-35427459

RESUMEN

Background: Intimate partner violence (IPV) is a complex global problem that has serious health consequences for victims. Many intervention programs have been introduced for IPV, with various target populations, purposes, designs, and outcomes. However, a consensus has not been reached regarding which type of program has the greatest impact. Therefore, the purpose of this study was to examine the effects of existing interventions on IPV risk and to compare the effects of the interventions based on their purposes and designs. Method: A systematic review and meta-analytic method were utilized in this study. Through a rigorous database search, 13 randomized controlled trials that met the inclusion and exclusion criteria were selected and included in the analysis. Results: The included interventions had a small effect size, which was statistically significant. The couple interventions aiming to reduce the risk of IPV perpetration and victimization simultaneously showed the greatest impact, compared to bystander interventions and interventions targeting either perpetrators or victims. The interventions aiming to reduce the risk of IPV perpetration showed a significant impact on changing gender equality-related knowledge and attitudes, and those aiming to reduce the risk of IPV victimization were effective in increasing knowledge and changing attitudes related to traditional norms, empowerment, and health conditions. The interventions targeting bystanders showed significant effects on increasing bystander-related attitudes and behaviors. Conclusion: Our findings provide strong evidence for future intervention programs for IPV. Long-term research to follow-up actual IPV reductions after interventions will be needed to confirm the findings of this study.


Asunto(s)
Acoso Escolar , Víctimas de Crimen , Violencia de Pareja , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Violencia de Pareja/prevención & control , Actitud
19.
Nat Commun ; 13(1): 6274, 2022 10 28.
Artículo en Inglés | MEDLINE | ID: mdl-36307405

RESUMEN

Although accumulating evidence indicates that alternative splicing is aberrantly altered in many cancers, the functional mechanism remains to be elucidated. Here, we show that epithelial and mesenchymal isoform switches of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) regulated by epithelial splicing regulatory protein 1 (ESRP1) correlate with metastatic potential of gastric cancer cells. We found that expression of the splicing variants of LRRFIP2 was closely correlated with that of ESRP1. Surprisingly, ectopic expression of the mesenchymal isoform of LRRFIP2 (variant 3) dramatically increased liver metastasis of gastric cancer cells, whereas deletion of exon 7 of LRRFIP2 by the CRISPR/Cas9 system caused an isoform switch, leading to marked suppression of liver metastasis. Mechanistically, the epithelial LRRFIP2 isoform (variant 2) inhibited the oncogenic function of coactivator-associated arginine methyltransferase 1 (CARM1) through interaction. Taken together, our data reveals a mechanism of LRRFIP2 isoform switches in gastric cancer with important implication for cancer metastasis.


Asunto(s)
Neoplasias Hepáticas , Neoplasias Gástricas , Humanos , Proteínas Adaptadoras Transductoras de Señales/genética , Proteínas Adaptadoras Transductoras de Señales/metabolismo , Empalme Alternativo , Línea Celular Tumoral , Transición Epitelial-Mesenquimal , Neoplasias Hepáticas/genética , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , Proteínas de Unión al ARN/genética , Proteínas de Unión al ARN/metabolismo , Neoplasias Gástricas/genética , Factores de Transcripción/metabolismo , Metástasis de la Neoplasia
20.
Int J Cancer ; 151(7): 1024-1032, 2022 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-35554932

RESUMEN

Our study investigated the incidence of secondary nonhematologic malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT) and explored its risk compared to the general population. A population-based case cohorts with adult patients who received allo-SCT between January 2002 and December 2018 and a control cohort with matched general population were extracted from the Korean National Health Insurance Service database. Each case and control cohort included 5177 patients. With a median follow-up of 2374 days for the case cohort and 2269 days for the control cohort, the 10-year cumulative incidence rate of nonhematologic malignancy was significantly higher in the case cohort compared to the control cohort (4.23% vs 2.3%, hazard ratio [HR] 1.73, 95% confidence interval [CI] 1.32-2.25, P < .001). The sub-class analysis according to cancer-site revealed significantly higher risks of 10-year cumulative incidence for cancers of head, neck and esophagus (HR 3.19, 95% CI 1.34-7.59, P = .003); cancers involving upper gastrointestinal tract (HR 3.74, 95% CI 1.58-8.85, P < .001), colorectal cancer (HR 2.02, 95% CI 1.04-3.91, P = .029), thyroid cancer (HR 2.09, 95% CI 1.1-3.97, P = .012), gynecological cancer (HR 2.69, 95% CI 1.04-6.96, P = .048) in the case cohort compared to the control cohort. No significant differences were detected for cancers involving lung, mediastinum and heart, breast cancer in female, cancers of the hepatobiliary and pancreatic system and cancers associated with urological system. These findings suggest the need for enhanced screening for nonhematologic malignancies in allo-SCT recipients compared to the general population.


Asunto(s)
Trasplante de Células Madre Hematopoyéticas , Neoplasias Primarias Secundarias , Adulto , Estudios de Casos y Controles , Estudios de Cohortes , Femenino , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Humanos , Neoplasias Primarias Secundarias/epidemiología , Neoplasias Primarias Secundarias/etiología , Modelos de Riesgos Proporcionales , Estudios Retrospectivos
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