RESUMEN
NR+ is a highly effective vitamin B3 type supplement due to its unique ability to replenish NAD+ levels. While NR+ chloride is already on the market as a nutritional supplement, its synthesis is challenging, expensive, and low yielding, making it cumbersome for large-scale industrial production. Here we report the novel crystalline NR+ salts, d/l/dl-hydrogen tartrate and d/l/dl-hydrogen malate. Their high-yielding, one-pot manufacture does not require specific equipment and is suitable for multi-ton scale production. These new NR+ salts seem ideal for nutritional applications due to their bio-equivalence compared to the approved NR+ chloride. In addition, the crystal structures of all stereoisomers of NR+ hydrogen tartrate and NR+ hydrogen malate and a comparison to the known NR+ halogenides are presented.
Asunto(s)
Aditivos Alimentarios/química , Tecnología de Alimentos/métodos , Niacinamida/análogos & derivados , Niacinamida/química , Compuestos de Piridinio/química , Aniones , Técnicas de Química Sintética , Cloruros , Cristalización , Suplementos Dietéticos , Hidrógeno/química , Espectroscopía de Resonancia Magnética , Malatos/química , Oxidación-Reducción , Sales (Química) , Estereoisomerismo , Tartratos/química , Difracción de Rayos XRESUMEN
We have prepared the indium(III)-centered, all-acetate-capped polyoxopalladate(II) nanocube [InPd12O8(OAc)16]5- (InPd12Ac16), which can be further used as precursor to form the phosphate-capped (i) double-cube [In2Pd23O17(OH)(PO4)12(PO3OH)]21- (In2Pd23P13) and (ii) monocube [InPd12O8(PO4)8]13- (InPd12P8). All three novel polyoxopalladates (POPs) were synthesized using conventional one-pot techniques in aqueous solution and characterized in the solid state (single-crystal XRD, IR, elemental analysis), in solution (115In, 31P, and 13C NMR), and in the gas phase (ESI-MS).
