[A preclinical study of ximedone]. / Dolkinicheskoe issledovanie ksimedona.

Pharmacotoxicological properties of ximedone, a new pyrimidine derivative, were studied experimentally on animals of various species. In the enteral regimen the drug had a favourable effect on thermal burns and postoperative cutaneous and gastric wounds. The results enabled to recommend ximedone for the clinical practice.

[Adaptation-reposition technological means in combination with a bioactive preparation Ximedon for stimulation of wound healing]. / Adaptatsionno-repozitsionnye tekhnicheskie sredstva v sochetanii s bioaktivnym farmakologicheskim preparatom ksimedon dlia stimuliatsii zazhivleniia ran.

The paper proposes a working classification of devices for intra- and extrafocal transtissue vulnosynthesis with the concurrent use of the agents that enhance reparative regeneration. Evaluating wound closure with wound adapters or routine suture has shown the advantages of the techniques by employing the proposed devices: the latter accelerates and facilitates suture application reparative, increases atraumaticity, asepticity, creates conditions for forming a precision suture. The positive results of experimental studies and clinical observations suggest that wound adapters have promises in practical application, transtissue device-aided vulnosynthesis in combination with topical pyrimidine derivatives, such as ximedon, shows great opportunities in soft tissue lesions.