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1.
Sci Rep ; 11(1): 17237, 2021 08 26.
Artículo en Inglés | MEDLINE | ID: mdl-34446812

RESUMEN

Ground-glass opacities (GGOs) are a non-specific high-resolution computed tomography (HRCT) finding tipically observed in early Coronavirus disesase 19 (COVID-19) pneumonia. However, GGOs are also seen in other acute lung diseases, thus making challenging the differential diagnosis. To this aim, we investigated the performance of a radiomics-based machine learning method to discriminate GGOs due to COVID-19 from those due to other acute lung diseases. Two sets of patients were included: a first set of 28 patients (COVID) diagnosed with COVID-19 infection confirmed by real-time polymerase chain reaction (RT-PCR) between March and April 2020 having (a) baseline HRCT at hospital admission and (b) predominant GGOs pattern on HRCT; a second set of 30 patients (nCOVID) showing (a) predominant GGOs pattern on HRCT performed between August 2019 and April 2020 and (b) availability of final diagnosis. Two readers independently segmented GGOs on HRCTs using a semi-automated approach, and radiomics features were extracted using a standard open source software (PyRadiomics). Partial least square (PLS) regression was used as the multivariate machine-learning algorithm. A leave-one-out nested cross-validation was implemented. PLS ß-weights of radiomics features, including the 5% features with the largest ß-weights in magnitude (top 5%), were obtained. The diagnostic performance of the radiomics model was assessed through receiver operating characteristic (ROC) analysis. The Youden's test assessed sensitivity and specificity of the classification. A null hypothesis probability threshold of 5% was chosen (p < 0.05). The predictive model delivered an AUC of 0.868 (Youden's index = 0.68, sensitivity = 93%, specificity 75%, p = 4.2 × 10-7). Of the seven features included in the top 5% features, five were texture-related. A radiomics-based machine learning signature showed the potential to accurately differentiate GGOs due to COVID-19 pneumonia from those due to other acute lung diseases. Most of the discriminant radiomics features were texture-related. This approach may assist clinician to adopt the appropriate management early, while improving the triage of patients.


Asunto(s)
Prueba de COVID-19/métodos , COVID-19/diagnóstico , Radiometría/métodos , SARS-CoV-2/fisiología , Anciano , Anciano de 80 o más Años , Prueba de Ácido Nucleico para COVID-19 , Femenino , Humanos , Pulmón , Aprendizaje Automático , Masculino , Persona de Mediana Edad , Curva ROC , Estudios Retrospectivos , Sensibilidad y Especificidad , Tomografía Computarizada por Rayos X
2.
Int Med Case Rep J ; 10: 173-175, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28579838

RESUMEN

Several small molecules, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), such as gefitinib, erlotinib and afatinib, have been demonstrated to significantly improve clinical outcomes in patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC), but erlotinib activity in EGFR wild-type squamous carcinoma is still highly debated. Here, we describe a prolonged and unexpected clinical response to erlotinib in a male former heavy cigarette smoker with wild-type EGFR squamous-cell cancer.

3.
Ann Thorac Surg ; 86(5): 1680-1, 2008 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19049777

RESUMEN

Sternum infection after cardiac surgery represents a severe complication with a high mortality rate. Therapeutic possibilities consist in "open packing" with specific antibiotic irrigation or in "en-block" resection. We report a case of sternum reconstruction using a titanium patch covered with bone-powder.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos/efectos adversos , Drenaje/métodos , Derrame Pericárdico/etiología , Derrame Pericárdico/terapia , Esternón/cirugía , Infección de la Herida Quirúrgica/etiología , Infección de la Herida Quirúrgica/terapia , Humanos , Masculino , Persona de Mediana Edad , Recurrencia , Vancomicina/uso terapéutico
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