RESUMEN
The present review covers a concise account of the synthesis of bioactive 2, 3-disubstituted-quinazoline-4(3H)-ones and the recent developments in the area of versatile quinazolinones with a special emphasis on new synthetic routes and strategies.
Asunto(s)
Quinazolinonas/síntesis química , Benzoxazinas/química , Diamida/química , Microondas , Quinazolinonas/química , Ácidos Sulfúricos/químicaRESUMEN
Industrial chemistry in the new millennium is widely adopting the concept of "Green chemistry" to meet the fundamental scientific challenges. Antihypertensive drugs include several of the most widely prescribed drugs like diuretics, beta-blockers, ACE inhibitors, calcium channel blockers, and α-1 adrenoreceptor blockers. The discovery of prazosin, with very high index of α1/α2 affinity has triggered off a renaissance of interest in α1-adrenoceptor antagonist drugs for treatment of hypertension. The three reported routes for synthesis and manufacture of the α-adrenoceptor antagonist- prazosin had some disadvantages. In present study we had developed new methods for the synthesis of prazosin by using microwave. The most important aspect is the overall yield of this process was ~25 % higher than the other reported methods excluding the use of banned substances.
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The paper documents traditional herbal remedies from buldhana district of Maharashtra (India). The plant parts most commonly used are bark, leaves, flowers, fruits and seeds, apart from plant products like latex and gum. The medicaments include recipes like decoction, infusion, paste, ash, extract juice, besides gum and latex. There are mainly used afresh. Occasionally, these are supplemented by domestic edible substances of plant-origin. The reliance on herbal medicines for healthcare is associated with traditional belief of effectiveness as well as poor economic status. Role of homestead gardens in native phytotherapy is being focused for the first time from this region. The first-hand information adduced is desired to divulge new lead molecules or will add new sources of herbal medicine.
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The tribals such as Kokana, Mahadeo-Koli, Bhil, Warali, Thakur, Katkari etc. and rural people of Nasik district use different parts of plants in crude form as cures against eye and ear afflictions. This paper deals with 13 plant species of which five species are employed by preparing formulations like juice, pulp and contact of drug in case of eye diseases. These are prepared from leaves, stem-bark and roots and administered for conjunctivitis, cataract and burning sensation of eyes. Likewise, eight species are used to cure ear-diseases by using drugs in the form of juice obtained from leaves, young stem-bark and fruits. Out of 13 species, five species each against eye and ear complaints are being reported for the first time. Modern laboratory methods and techniques are, however, required to reveal new lead molecules.
RESUMEN
Traditional medicinal uses for various human diseases of 54 angiospermic species from Shegaon, Sangrampur, Jalgaon (Jamod), Malkapur, Nandura, Motala and Khamgaon tehsils of Buldhana district (Maharashtra) are reported. Of these, applications of 36 species are unknown or little known. The folk medicines consist of a sole drug or a principal drug in combination with other drugs. The recent botanical name, local plant name, recipe, mode of administration, doses etc. are communicated as collected from the tribal and rural folks of the district. It is desirable to screen these species on modern scientific lines.
RESUMEN
The aborigines exploit medicinal virtues of tubers, roots fruits, seeds, flowers, leaves etc. from the forest and use in a variety of ways. The are used in the form of juice, decoction, oil, paste, extract, infusion and powder. Fresh parts are also used and the substances like sugar, sugarcandy, groundnut oil, milk and cow-ghee are used as additives. The native uses of medicinal plants are employed to better stomachcomplaints, rheumatic pains, spermatorrhoea, tooth-ache, head-ache, ear-ache, weakness, urinal troubles, fresh cuts, tumors, fever, mouth ulcer, bone fracture and few other human diseases. Total 47 species are being reported for the aforesaid ailments of these, applications of 32 species are unknown or little known. These are, however, desired for further scientific assessments for obvious reasons.
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The study concerns the first-hand information gathered during ethnomedicinal surveys in Nasik district, Maharashtra, of plants traditionally used by aborigines and rural folks for the treatment of gynecological, genital and other related aspects. Uses of 25 angiospermic species belonging to 22 population. The paper gives botanical identity, family, local name, collection number and mode of administration.
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The study concerns the first -hand information on 50 ethnomedicinal plants traditional used by aborigines and rural folks of Nasik district, Maharashtra, for the treatment of various human ailments and disorders. The paper gives botanical identity, local name, family and mode of administration.
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The drug safed-musali' has always remained the subject of dispute and object of investigations. This paper evaluates comparatively its ethnomedicinal records as also those found in literature on the modern usage in Indian context alongwith the observations of the present author. The safedmusali belongs to the various species of two different well known liliaceous genera viz., Asparagus L. and Chlorophytum Ker-Gowl., and a least known orchidaceous genus Pachystoma Bl.It appears that the wide modern usage of safed-musali might have sprung from its ethnomedicinal leads in our country. The plant sources of its procurement although varied should be regarded only as surrogates for each other. The drug itself is a substitute for 'Salep' or 'Salep-misri'. In the light of present investigation, it is surveyed, reviewed and highlighted pertinently. The attempts to cultivate different species which are implicated as safed-musali need a fillip for the betterment of tribal people and Indian societies at large.
RESUMEN
Fifty plants belonging to 33 angiospermic families used by aborigines and rurals for different human ailments hitherto unreported from Jalgaon district. Maharashtra, India are communicated. Further scientific evaluation on pharmacological and clinical lines is needed for these widely employed herbal medicines.
RESUMEN
The Present paper reports 36 wild edible angiospermic species from Nasik district of Maharashtra. The district is inhabited by the aborigines viz Bhils, Thakur, Katkari, Warli, Kokani, Kunbi-Kokana a Mahadeo-Koli, apart from other rural populace. The use leaves, tubers rhizoms, bulbils, fruits, seeds, flowers, etc as complementary to their diet or in a times of scarcity during famines.