[Primary malignant melanoma of the uterine cervix--case report and review of the literature]. / Das primär maligne Melanom der Cervix uteri--Fallbericht und Literaturüberblick.

We present a case of primary malignant melanoma of the cervix uteri. The prognosis of this very rare tumor is rather poor. Radical abdominal hysterectomy combined with partial colpectomy, bilateral adnexectomy and dissection of the pelvine lymph-nodes seems to improve the clinical outcome even if an additional brachytherapy is added.

[Hormonal contraception and vaginal mycoses].

PIP: The incidence of vaginal mycoses caused by the use of oral contraceptives has been examined in a variety of studieswwhich generally conclude that the use of such preparations does promote conditions favorable for the development of this disease. Combination preparations are found to cause more incidences than sequential monophasic ones. As those patients with diabetes are more susceptible to vaginal mycoses, particular attention must be given to the use of hormonal preparations. Some sources note that the pH level of the vaginal mucus is a significant factor in the development of mycoses. As the use of hormonal preparations effects these levels, the correlation is considered possibly important. But these factors are not completely understood. The problem remains unresolved for further study.^ieng

[Liver function in hormonal contraception]. / Leberfunktion bei hormonaler Kontrazeption

Numerous interactions between hormonal contraceptives and liver function have been described. Changed laboratory results do not represent obligatory pathologic conditions or hepatotoxi effects. Some of these changed results are transient, suggesting that liver cells are capable of adaptation. The use of oral contraceptives is contraindicated in the following liver diseases: - recurrent intrahepatic cholestasis (recurrent jaundice of pregnancy, Dubin-Johnson syndrome, Rotor syndrome); - acute disturbances of liver function. In general it is recommended that hormonal contraceptives should not be used by patients with biliary cirrhosis although some authors have stated that chronic disturbances of liver function did not appear to be aggravated by these agents. Impairment of carbohydrate and lipid metabolism needs careful control of the laboratory tests concerned. Due to its low frequency the increased risk of gallstones does not necessitate the withdrawal of the medication. Up to now the interrelationship between the use of contraceptive steroids and the induction of hepatic tumours has not been proven.