To study the mechanism of Scutellariae Radix and Astragaloside in the treatment of lung cancer based on network pharmacology.

The aim of the study wasto explore the target and potential mechanism of Scutellariae Radix and Astragaloside in the treatment of lung cancer infection by network pharmacology. The target information of baicalein and flavonin was mined from CTD database and Swiss database. Genecards database, DRUGBANK database, and OMIM database were used to search for lung cancer related genes. The target protein network map (PPI) was drawn by using the STRING database analysis and Cytoscape3.7.1 software. With the help of Perl language, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and gene function analysis (GO) enrichment analysis were carried out by using the biological program package of R language. In total, 347 biological targets of Astragaloside and Scutellariae Radix were identified through the collection and analysis of multiple databases. In total, 1526 lung cancer targets were obtained from a multi-disease database. The "component-target" network of Astragaloside and Scutellariae Radix was constructed, and the protein interaction network (PPI) of the overlapping targets was analyzed to identify the key targets of drug-influenced diseases. In addition, KEGG pathway analysis and GO enrichment analysis were performed on the overlapping targets to explore the mechanism of Scutellariae Radix and Astragaloside in the treatment of lung cancer. Scutellariae Radix and Astragaloside have the characteristics of multi-component, multi-target and multi-pathway in the treatment of lung cancer, which provides a new idea and scientific basis for further research on the molecular mechanism of the antilung cancer effect of Scutellariae Radix and Astragaloside.

Preparation of Activated Carbon From Polygonum orientale Linn. to Remove the Phenol in Aqueous Solutions.

Phenol components are major industry contaminants of aquatic environment. Among all practical methods for removing phenol substances from polluted water, activated carbon absorption is the most effective way. Here, we have produced low-cost activated carbon using Polygonum orientale Linn, a wide spreading species with large biomass. The phenol adsorption ability of this activated carbon was evaluated at different physico-chemical conditions. Average equilibrium time for adsorption was 120 min. The phenol adsorption ability of the P. orientale activated carbon was increased as the pH increases and reached to the max at pH 9.00. By contrast, the ionic strength had little effect on the phenol absorption. The optimum dose for phenol adsorption by the P. orientale activated carbon was 20.00 g/L. The dominant adsorption mechanism of the P. orientale activated carbon was chemisorption as its phenol adsorption kinetics matched with the pseudo-second-order kinetics. In addition, the equilibrium data were fit to the Langmuir model, with the negative standard free energy and the positive enthalpy, suggesting that adsorption was spontaneous and endothermic.