RESUMEN
After the onset of a long-term low dose rate radiation exposure (55-60 y later) of the Techa riverside residents within a range of individual red bone marrow (RBM) doses from 0.01 to 1.79 Gy, it was established that there was an obvious association between the type of reaction manifested by peripheral blood lymphocytes to small dose irradiation in vitro (adaptive potential) and the RBM cell composition (during the period of the major exposure), as well as the peripheral blood cell composition (at a late time period coincident with the studies of induced radioresistance). The nature of these dependencies observed in chronically exposed individuals differs from that revealed in the controls. Based on the results of the study, it can be suggested that the capacity for adaptive response shown by peripheral blood lymphocytes donated by exposed persons at late time after exposure can be regarded as a biological marker of the functional state of the hemopoietic stem cell pool.
Asunto(s)
Inmunidad Adaptativa/efectos de la radiación , Exposición a Riesgos Ambientales/efectos adversos , Exposición a Riesgos Ambientales/análisis , Hematopoyesis/efectos de la radiación , Linfocitos/inmunología , Linfocitos/efectos de la radiación , Biomarcadores/sangre , Relación Dosis-Respuesta en la Radiación , Hematopoyesis/inmunología , HumanosRESUMEN
We studied the relationship between cytogenetic abnormalities in buccal epithelial cells and metabolic shifts in children with scoliosis and kyphosis. The incidence of nucleus abnormalities and the corresponding metabolic shifts were found to depend on the presence of spinal deformities and ecological factors. The problem of formation of risk groups for spinal deformities in ecologically unfavorable regions is discussed.
