Physical Activity at Different Life Stages and Its Consequence on the Initial Immunization and Inflammatory Response Against COVID-19.

BACKGROUND: To evaluate the influence of previous physical activity (PA) during childhood, adolescence, and current PA practice on the production of antibodies and inflammatory response between the first and second doses of the COVID-19 vaccine. METHODS: Fifty-nine men and 56 women were evaluated before the first vaccine, and 12 weeks later, blood samples were taken to quantify production of anti-severe acute respiratory syndrome coronavirus-2 immunoglobulin G antibodies and cytokines. Previous PA during childhood and adolescence was self-referred, and current PA was assessed using the International Physical Activity Questionnaire. RESULTS: A positive and significant association was observed only between PA practice during adolescence and an increase in antibody production in adulthood (ß = 2012.077, 95% confidence interval, 257.7953-3766.358, P = .025). Individuals who practiced PA during adolescence showed higher production of antibodies between the first and second vaccine dose compared to nonpractitioners (P = .025) and those that accumulated ≥150 minutes per week of current moderate-vigorous PA (MVPA), and presented higher antibody production in relation to who did <150 minutes per week of MVPA (P = .046). Individuals that were practitioners during childhood produced higher G-CSF (P = .047), and those that accumulated ≥150 minutes per week of current MVPA demonstrated lower IP-10 levels (P = .033). However, PA practitioners during adolescence presented higher G-CSF (P = .025), IL-17 (P = .038), IL-1RA (P = .005), IL-1ß (P = .020), and IL-2 (P = .026) levels. CONCLUSION: Our results suggest that adults that accumulated at least 150 minutes of MVPA per week or practiced PA during adolescence developed an improved immune and inflammatory response against COVID-19 vaccination.

Pandemia da Covid-19: Prática de Lazer entre Professores Brasileiros / Covid-19 pandemic: leisure practice among teachers brazilian

Neste estudo, examinamos as atividades de lazer entre os professores durante a COVID-19, avaliando questões relacionadas ao perfil sociodemográfico e às condições de trabalho. Trata-se de um websurvey transversal, realizado com professores da educação básica pública de Minas Gerais. Foi utilizado um formulário digital para a coleta de dados em 2020. A prática de lazer na pandemia foi a variável dependente. Na análise múltipla, foi utilizada a regressão de Poisson. Participaram do estudo 15.641 professores, dos quais 43% não estavam tendo práticas de lazer na pandemia. Houve maior prevalência de ausência da prática de lazer entre as mulheres, entre os idosos, professores pardos e pretos, contratados/designados e insatisfeitos com o trabalho docente na pandemia. Assim, esta pesquisa buscou discutir temas socioculturais, destacando que o acesso às práticas de lazer carece de uma visão social, humana e voltada para a desigualdade.

In this study, we examined leisure activities among teachers during the COVID-19, assessing issues related to sociodemographic profile and working conditions. This is a cross-sectional websurvey, performed with teachers of public basic education of Minas Gerais. A digital form was used to collect data in 2020. Leisure practice in pandemic was the dependent variable. In the multiple analysis, Poisson regression was used. A total of 15,641 teachers participated in the study, of which 43% were not having leisure practices in pandemic. There was a higher prevalence of absence of leisure practice among women, among the elderly, brown and black-skinned teachers, contracted/designated teachers and those not satisfied with teaching work in pandemic. Thus, this research sought to discuss sociocultural topics, highlighting, that access to leisure practices lacks a social, human vision focused on the inequality.

Catalyst-Free Click Chemistry for Engineering Chondroitin Sulfate-Multiarmed PEG Hydrogels for Skin Tissue Engineering.

The quest for an ideal biomaterial perfectly matching the microenvironment of the surrounding tissues and cells is an endless challenge within biomedical research, in addition to integrating this with a facile and sustainable technology for its preparation. Engineering hydrogels through click chemistry would promote the sustainable invention of tailor-made hydrogels. Herein, we disclose a versatile and facile catalyst-free click chemistry for the generation of an innovative hydrogel by combining chondroitin sulfate (CS) and polyethylene glycol (PEG). Various multi-armed PEG-Norbornene (A-PEG-N) with different molecular sizes were investigated to generate crosslinked copolymers with tunable rheological and mechanical properties. The crosslinked and mechanically stable porous hydrogels could be generated by simply mixing the two clickable Tetrazine-CS (TCS) and A-PEG-N components, generating a self-standing hydrogel within minutes. The leading candidate (TCS-8A-PEG-N (40 kD)), based on the mechanical and biocompatibility results, was further employed as a scaffold to improve wound closure and blood flow in vivo. The hydrogel demonstrated not only enhanced blood perfusion and an increased number of blood vessels, but also desirable fibrous matrix orientation and normal collagen deposition. Taken together, these results demonstrate the potential of the hydrogel to improve wound repair and hold promise for in situ skin tissue engineering applications.

Familial lecithin-cholesterol acyltransferase deficiency: If so rare, why so frequent in the state of Piauí, northeastern Brazil?

Lecithin-cholesterol acyltransferase (LCAT), an enzyme that participates in lipoprotein metabolism, plays an important role in cholesterol homeostasis. Mutations in the LCAT gene can cause two rare genetic disorders: familial LCAT deficiency (FLD), which is characterized by corneal opacities, normocytic anemia, dyslipidemia, and proteinuria progressing to chronic renal failure, and fish-eye disease (FED), which causes dyslipidemia and progressive corneal opacities. Herein, we report six suspected cases of FLD in the backlands of Piauí, located in northeast Brazil. A genetic diagnosis was performed in index cases. Among these, a further investigation was performed to identify new cases in the families. In addition, molecular analyses were performed to verify the levels of consanguinity within families and the existence of a genetic relationship between them. All six index cases were confirmed as FLD with an identical mutation (c.803G > A, p.R268H). The genetic investigation confirmed another 7 new cases of FLD, 52 heterozygous and 6 individuals without mutations. The rate of consanguinity revealed that marriages within the family did not contribute to the high number of FLD cases within the restricted region. The elders of each family (patriarchs and matriarchs) were subjected to a kinship analysis and were more genetically related to each other than the control group. Bayesian analysis was implemented to confirm the hypothesis of connectivity among patriarchs and matriarchs and indicated that they were genetically more related to each other than would be randomly expected, thus suggesting the occurrence of a possible founder effect in these families.

Para atletas brasileiros(as) retratados(as) nas notícias do comitê paralímpico brasileiro: distanciamento social na pandemia de COVID-19 / Brazilian parathletes represented in brazilian paralympic committee news: social distance in the COVID-19 pandemic / Paratletas brasileños representados en noticias del comité paralímpico brasileño: distancia social en la pandemia COVID-19

Este artigo buscou averiguar os impactos da pandemia de COVID-19 no percurso esportivo de Para atletas brasileiros(as) veiculados nas notícias do site do Comitê Paralímpico Brasileiro. Foram realizados o levantamento e a catalogação de notícias do site do Comitê Paralímpico Brasileiro e, na sequência, procedeu-se à técnica de análise temática de conteúdo das notícias. Evidenciamos os seguintes temas: incertezas quanto aos Jogos Paralímpicos 2020; saudades das relações interpessoais; aproximação com a família; aumento das interações virtuais; prática de exercícios físicos com orientações virtuais; preocupações com o peso corporal; dificuldades com o sono; falta de disposição para treinar em casa; e expectativas quanto ao retorno dos treinos presenciais. Distintas estratégias foram adotadas a fim de mitigar os impactos da pandemia no esporte paralímpico no país.

This article sought to investigate the impacts of the COVID-19 pandemic on the sporting route of For Brazilian athletes published in the news on the Brazilian Paralympic Committee website. A survey and cataloging of news from the website of the Brazilian Paralympic Committee were carried out and, subsequently, the technique of thematic analysis of news content was carried out. We highlight the following themes: uncertainties about the 2020 Paralympic Games; missing interpersonal relationships; closeness with the family; increase of virtual interactions; practice of physical exercises with virtual guidance; concerns about body weight; sleeping difficulties; lack of willingness to train at home; expectations about the return of in-person training. Different strategies were adopted in order to mitigate the impacts of the pandemic to Paralympic sports in the country.

Este artículo buscó investigar los impactos de la pandemia COVID-19 en la ruta deportiva de los deportistas brasileños publicados en las noticias del sitio web del Comité Paralímpico Brasileño. Se realizó un relevamiento y catalogación de noticias de la página web del Comité Paralímpico Brasileño y, posteriormente, se llevó a cabo la técnica de análisis temático de contenido informativo. Destacamos los siguientes temas: incertidumbres sobre los Juegos Paralímpicos 2020; falta de relaciones interpersonales; cercanía con la familia; aumento de interacciones virtuales; práctica de ejercicios físicos con guía virtual; preocupación por el peso corporal; dificultades con el sueño; falta de voluntad para entrenar en casa; expectativas sobre el regreso del entrenamiento presencial. Se adoptaron diferentes estrategias para mitigar el impacto de la pandemia en el deporte paralímpico del país.

A dança no espaço público da cidade - o "projeto forró na praça": dos encontros e da liberdade / Dance in the public space of the city - "forró na praça" project: meetings and freedom

Este estudo versa sobre os sentidos atribuídos pelos frequentadores de um projeto denominado "Forró na Praça" à vivência da dança no espaço público da praça, sendo este espaço parte constitutiva da cidade, presente na realidade com seus objetos e formado pela contínua interação humana. Para desenvolvimento desta pesquisa foram realizadas observações simples das aulas de dança do projeto e aplicadas entrevistas semiestruturadas ao coordenador do projeto e a três participantes. Os dados coletados foram analisados segundo análise qualitativa do conteúdo, sendo constatado que o dançar na praça promove sociabilidade e novas experiências, podendo se constituir em uma vivência de lazer significativa para os participantes. A praça, pública e aberta, convida "facilmente" aqueles que ocupam e percorrem a cidade a viver a dança neste espaço/paisagem.

This investigation discusses the meanings attributed by the participants of a project called "Forró na Praça" to the experience of dance in the public space of the square. This space is a constituent part of the city, present in reality with its objects and formed by continuous human interaction. For the development of this research, simple observations were made of the dance classes held in the project and semi-structured interviews were applied to the project coordinator and to three participants. The collected data were interpreted according to the qualitative content analysis procedures. From this analysis, it was possible to verify that the possibility of dancing in the square promotes sociability and new experiences, which can constitute a significant leisure experience for the participants. The square, public and open, invites "easily" those who occupy and travel the city to live the dance in this space/landscape.

pHLA3D: Updating the database of predicted three-dimensional structures of HLA with HLA-DR, HLA-DQ and HLA-DP molecules.

To improve the availability of three-dimensional (3D) structures of HLA molecules, we created the pHLA3D database. In its first version, we modeled and published 106 3D structures of HLA class I molecules from the HLA-A, HLA-B, and HLA-C loci. This paper presents an update of this database, providing more 127 3D structures of HLA class II molecules (41 DR, 42 DQ, and 44 DP), predicted via homology modeling with MODELLER and SWISS-MODEL. These new 3D structures of HLA class II molecules are now freely available at pHLA3D (www.phla3d.com.br) for immunologists and other researchers working with HLA molecules.

Brazil's participation in the 1936 olympic games in Berlin: internal conflicts among groups / A participação do Brasil nos jogos olímpicos de 1936, em Berlim: conflitos internos entre grupos / La participación de Brasil en los juegos olímpicos de Berlín de 1936: conflictos internos entre grupos

Abstract The research investigates Brazil's participation in the 1936 Olympic Games, in particular the case of Brazilian rower Fritz Richter, who did not take part in rowing competitions in Berlin, even though he was part of the delegation organized by the Brazilian Confederation of Sports (CBD). The information about Brazil's participation came from newspaper and magazine reports. The interpretation of the sources revealed that the decision about participating in the Olympics was marked by conflicts that ended up with two delegations representing the country in the event. This culminated in the selection of Brazilian athletes in German territory. In that context, there were other conflicts, not only during the Brazilian delegations' stay in Berlin but also when they returned to Brazil. Such events indicate that Brazilian Olympic sports in the 1930s were experiencing incipient times.

Resumo A pesquisa investiga a participação do Brasil nas Olimpíadas de 1936, em particular, o caso do remador brasileiro Fritz Richter, que não disputou competições de remo em Berlim, embora tenha feito parte da delegação organizada pela Confederação Brasileira de Desportos (CBD). As informações sobre a participação brasileira vieram de reportagens de jornais e revistas. A interpretação das fontes revelou que a decisão da participação do Brasil nos Jogos Olímpicos foi marcada por conflitos, afetando o envio de duas delegações para representar o país no evento. Esse fato culminou na seleção de atletas brasileiros em território alemão. Nessa conjuntura, ocorreram outros conflitos, não apenas durante a permanência das delegações brasileiras em Berlim, mas quando retornaram ao país. Tais eventos indicam que o esporte olímpico brasileiro na década de 1930 vivia um momento incipiente.

Resumen Este trabajo investiga la participación de Brasil en los Juegos Olímpicos de 1936, en particular, el caso del remero brasileño Fritz Richter, quien no disputó pruebas de remo en Berlín, pese a formar parte de la delegación organizada por la Confederación Brasileña de Deportes (CBD). Las informaciones sobre la participación brasileña provienen de reportajes de periódicos y revistas. La interpretación de las fuentes reveló que la decisión sobre la participación de Brasil en los Juegos Olímpicos estuvo marcada por conflictos, llevando al envío de dos delegaciones para representar al país en el evento. Este hecho culminó en la selección de atletas brasileños en territorio alemán. En esa coyuntura, hubo otros conflictos, no solo durante la estadía de las delegaciones brasileñas en Berlín, sino cuando éstas regresaron al país. Tales eventos indican que el deporte olímpico brasileño en la década de 1930 se encontraba en un estado incipiente.

Gazeta do Norte newspaper and the great Sports Square as nation projects: 'Mold for Tomorrow's Men!'

Abstract Aim: This study contextualizes the establishment of Montes Claros Sports Square, in Minas Gerais, through the look of Gazeta do Norte newspaper, and its alignment with a nation project to be established by the government of Getúlio Vargas, who took office in 1930. He formulated actions for a 'national reconstruction' project, for which, from society, it was necessary to emerge both physically and morally healthy subjects, fundamental conditions for the construction of the aforementioned new nation, and which could reach the Brazilians in the hinterlands. Thus, this study aimed to narrate a history of the construction of Montes Claros Sports Square, from the end of the 1930s until 1945, during Getúlio Vargas' first term as President of the Republic, with Benedito Valadares as Governor of Minas Gerais. Methods: The study was based on the extensive collection of data researched in Gazeta do Norte newspaper. Results: Symbol of a modern project for sports, the Sports Square was announced by the governor during his visit to the city, in January 1939, and established on the Oswaldo Cruz meadow. It is possible to verify that, notably, in the 15 years of Getúlio Vargas' first term, the practice of sports is developed and consolidates itself as an 'actor' in the social space of Montes Claros. Conclusion: In this city, in addition to the construction of the Sports Square, it was necessary to educate and inform the individuals. It can be said that the newspaper Gazeta do Norte firmly contributed to Vargas' nation project.

O divertimento importado: uma colonização cultural no sertão norte-mineiro / Imported amusement: cultural colonization in northern minas gerais's hinterland (sertão) / La diversión importada: una colonización cultural en el sertão del norte de minas gerais

Resumo Este estudo objetivou analisar o desenvolvimento de aspectos modernos na cidade de Montes Claros, na primeira metade do século XX, localizada no Norte do estado de Minas Gerais, e problematizou as tensões sociais existentes entre a aquisição de novos hábitos e as antigas tradições locais. Foram buscadas informações na imprensa jornalística da época, a partir do periódico Gazeta do Norte, o jornal de maior circulação da cidade de Montes Claros no período de 1918 a 1962. Identificou-se que, no sertão do Brasil do século XX, as diversões se constituíram em meio a tensões entre a tradição e o moderno. Para além disto, o tempo e o espaço locais estabeleceram relações com a formação do binômio trabalho e divertimento em Montes Claros. O advento da modernidade permitiu a apropriação, não sem resistências e tensões, de um conjunto de valores e práticas que se distinguiam das vigentes no ordenamento social até então.

Abstract This study analyzed the development of modern aspects of life in the first half of the 20th century in the city of Montes Claros, northern Minas Gerais, Brazil, and discussed the social tensions between acquisition of new habits and old local traditions. Information was sought from Gazeta do Norte, the most widely read newspaper in the city in 1918-1962. The study found that, in the Brazilian hinterland (known as sertão) of the 20th Century, forms of amusement were created amid tensions between tradition and the modernity. In addition, local time and space have established relations with the work/entertainment binomial in Montes Claros. The advent of modernity allowed appropriation - not without resistance and tensions - of a set of values and practices that were different from those that had prevailed in the social order so far.

Resumen Este estudio tuvo como objetivo analizar el desarrollo de aspectos modernos en la ciudad de Montes Claros, ubicada en el norte del estado de Minas Gerais, en la primera mitad del siglo XX, y problematizó las tensiones sociales existentes entre la adquisición de nuevos hábitos y las antiguas tradiciones locales. Se buscó información en la prensa de la época a partir del periódico Gazeta do Norte, el diario de mayor circulación en la ciudad de Montes Claros en el período de 1918 a 1962. Se identificó que, en el semiárido brasileño del siglo XX, las diversiones se constituyeron en medio a tensiones entre la tradición y la modernidad. Además, el tiempo y el espacio locales establecieron relaciones con la formación del binomio trabajo y entretenimiento en Montes Claros. El advenimiento de la modernidad permitió la apropiación, no sin resistencias y tensiones, de un conjunto de valores y prácticas que se diferenciaban de las imperantes en el orden social hasta entonces.

Etiological investigation of genetic cause in autism spectrum disorder / Investigação etiológica de causa genética na perturbação do espetro do autismo

AIMS: The aims of this study were to characterize the etiological investigation of genetic cause in the autism spectrum disorder and to determine the factors related to its identification. METHODS: A retrospective descriptive study, with an analytical component, included children and adolescents with autism spectrum disorder followed in consultation at a level 2 hospital, between November 2017 and October 2019. The following variables were analyzed: age, sex, age at the first consultation, family history, objective examination, cognitive assessment, etiological investigation of genetic cause and etiological diagnosis of genetic cause. Statistical analysis was performed using the SPSS®v23 program (significance level 0.05). RESULTS: We identified 153 children with autism spectrum disorder, of which 48 underwent a genetic cause investigation: 45 performed microarray analysis (15.6% pathogenic); 42 carried out a molecular study of the Fragile X syndrome (one altered); two performed sequencing of the methyl CpG binding protein 2 (MECP2) gene (one altered). The diagnosis of genetic cause was made in 18.8% of the sample. The identification of the etiology of a genetic cause was related to global development delay/ intellectual disability (p = 0.04) and the presence of relevant family history (p = 0.005). CONCLUSIONS: The diagnostic yield of the genetic study was higher in patients with a global development delay /intellectual disability and in patients with relevant family history.

OBJETIVOS: Os objetivos deste estudo foram caracterizar a investigação etiológica de causa genética na perturbação do espetro do autismo e determinar os fatores que se relacionam com a sua identificação. MÉTODOS: Um estudo retrospetivo descritivo, com componente analítica, incluiu crianças e adolescentes com perturbação do espetro de autismo seguidos em consulta num hospital nível 2 entre novembro de 2017 e outubro de 2019. As seguintes variáveis foram analisadas: idade, sexo, idade na primeira consulta, antecedentes familiares, exame objetivo, avaliação cognitiva, investigação etiológica de causa genética e diagnóstico etiológico de causa genética. A análise estatística foi realizada utilizando o programa SPSS®v23 (nível de significância 0,05). RESULTADOS: Identificámos 153 crianças com perturbação do espetro de autismo, das quais 48 realizaram investigação etiológica de causa genética: 45 realizaram microarray (alterações patogénicas 15,6%); 42 realizaram estudo molecular da síndrome X-Frágil (um alterado); dois realizaram sequenciação do gene MECP2 (um alterado). O diagnóstico de causa genética foi feito em 18,8% da amostra. A identificação de etiologia de causa genética relacionou-se com défice intelectual/atraso global do desenvolvimento psicomotor (p=0,04) e com a presença de antecedentes familiares relevantes (p=0,005). CONCLUSÕES: A rentabilidade diagnóstica do estudo genético foi superior em doentes com atraso global do desenvolvimento psicomotor/défice intelectual associado e com antecedentes familiares relevantes.

[Equine-assisted therapy, health and sports: figurations of the practice in the state of Rio Grande do Sul, 1970-2000]. / Equoterapia, saúde e esporte: figurações da prática no Rio Grande do Sul, 1970-2000.

Based on the theoretical assumptions of Norbert Elias, we sought to understand the figurations of equine-assisted therapy in Rio Grande do Sul from 1970 to 2000. To this end, the research corpus consisted of official documents, newspapers and magazines. Based on the concept of figuration, the documentation analyzed demonstrated technical-scientific elements linked to the fields of healthcare, education and horseback riding, coming from equestrianism and shared in the practice of equine-assisted therapy. The interrelations established between these different areas allowed the practice to take on attributes and representations emanating from the equestrian world. Thus, other figurations were developed in the field of equine-assisted therapy involving relationships between military and civil entities.

Com base nos pressupostos teóricos de Norbert Elias, objetivou-se compreender as figurações da equoterapia no Rio Grande do Sul no período demarcado entre 1970 e 2000. Para tanto, o corpus documental da pesquisa foi composto por documentos oficiais, jornais e revistas. A partir do conceito de figuração, a documentação analisada evidenciou elementos técnico-científicos, acoplados às áreas da saúde, educação e equitação, provenientes do hipismo e compartilhados na prática da equoterapia. As inter-relações estabelecidas entre essas áreas possibilitaram que tal prática congregasse atributos e representações emanadas do cenário hípico. Assim, constituíram-se outras figurações no campo da equoterapia, envolvendo relações entre entidades que congregavam militares e civis.

Equoterapia, saúde e esporte: figurações da prática no Rio Grande do Sul, 1970-2000 / Equine-assisted therapy, health and sports: figurations of the practice in the state of Rio Grande do Sul, 1970-2000

Resumo Com base nos pressupostos teóricos de Norbert Elias, objetivou-se compreender as figurações da equoterapia no Rio Grande do Sul no período demarcado entre 1970 e 2000. Para tanto, o corpus documental da pesquisa foi composto por documentos oficiais, jornais e revistas. A partir do conceito de figuração, a documentação analisada evidenciou elementos técnico-científicos, acoplados às áreas da saúde, educação e equitação, provenientes do hipismo e compartilhados na prática da equoterapia. As inter-relações estabelecidas entre essas áreas possibilitaram que tal prática congregasse atributos e representações emanadas do cenário hípico. Assim, constituíram-se outras figurações no campo da equoterapia, envolvendo relações entre entidades que congregavam militares e civis.

Abstract Based on the theoretical assumptions of Norbert Elias, we sought to understand the figurations of equine-assisted therapy in Rio Grande do Sul from 1970 to 2000. To this end, the research corpus consisted of official documents, newspapers and magazines. Based on the concept of figuration, the documentation analyzed demonstrated technical-scientific elements linked to the fields of healthcare, education and horseback riding, coming from equestrianism and shared in the practice of equine-assisted therapy. The interrelations established between these different areas allowed the practice to take on attributes and representations emanating from the equestrian world. Thus, other figurations were developed in the field of equine-assisted therapy involving relationships between military and civil entities.

PREPUBERTAL GYNECOMASTIA: A RARE MANIFESTATION OF MYOTONIC DYSTROPHY TYPE 1.

OBJECTIVE: To present a case of bilateral gynecomastia in a prepubertal boy with autism spectrum disorder, diagnosed with myotonic dystrophy type 1. CASE DESCRIPTION: A 12-year-old boy with autism spectrum disorder presented at a follow-up visit with bilateral breast growth. There was a family history of gynecomastia, cataracts at a young age, puberty delay, and myotonic dystrophy type 1. The physical examination showed that he had bilateral gynecomastia with external genitalia Tanner stage 1. Neurologic examination was regular, without demonstrable myotonia. The analytical study revealed increased estradiol levels and estradiol/testosterone ratio. After excluding endocrine diseases, the molecular study of the dystrophia myotonica protein kinase gene confirmed the diagnosis of myotonic dystrophy type 1. COMMENTS: A diagnosis of prepubertal gynecomastia should include an investigation for possible underlying diseases. This case report highlights the importance of considering the diagnosis of myotonic dystrophy type 1 in the presence of endocrine and neurodevelopmental manifestations.

Motor-cognitive dual-task performance of older women evaluated using Wii Balance Board.

BACKGROUND: Single- and dual-tasks are influenced by age-related impaired postural balance. Aim of this study was to analyze the Center of Pressure (CoP) oscillation during static balance in the presence or absence of cognitive task on older women. METHODS: Thirty-one healthy older women were assessed in a stand quiet position with open/closed eyes (single-task, OE and CE) and with cognitive task (dual-task, DT) through Wii Balance Board. Sway area, total displacement and CoP oscillation (CO) based on the number of times that CoP traveled through anteroposterior and mediolateral directions. Friedman test was used to compare OE, CE and DT. Dual-task interference percentage was used to quantify the cognitive load on balance whereas Spearman correlation coefficient was used to assess the association of cognitive domains and CO. RESULTS: The CO was significantly higher in DT than in single-tasks and participants were unable to maintain their limits of stability in mediolateral direction. The cost of DT interference was 30.5%, which is partially explained by the deviation of attention from postural control to spatial and temporal orientation. CONCLUSION: Our findings show that cognitive load during DT impairs balance in mediolateral direction, thus indicating the use of WBB to assess cognitive interference on postural control.

Equoterapia, saúde e esporte: figurações da prática no Rio Grande do Sul, 1970-2000 / Equine-assisted therapy, health and sports: figurations of the practice in the state of Rio Grande do Sul, 1970-2000

Com base nos pressupostos teóricos de Norbert Elias, objetivou-se compreender as figurações da equoterapia no Rio Grande do Sul no período demarcado entre 1970 e 2000. Para tanto, o corpus documental da pesquisa foi composto por documentos oficiais, jornais e revistas. A partir do conceito de figuração, a documentação analisada evidenciou elementos técnico-científicos, acoplados às áreas da saúde, educação e equitação, provenientes do hipismo e compartilhados na prática da equoterapia. As inter-relações estabelecidas entre essas áreas possibilitaram que tal prática congregasse atributos e representações emanadas do cenário hípico. Assim, constituíram-se outras figurações no campo da equoterapia, envolvendo relações entre entidades que congregavam militares e civis

Prepubertal gynecomastia: a rare manifestation of myotonic dystrophy type 1 / Ginecomastia pré-púbere: uma manifestação rara da distrofia miotônica tipo 1

ABSTRACT Objective: To present a case of bilateral gynecomastia in a prepubertal boy with autism spectrum disorder, diagnosed with myotonic dystrophy type 1. Case description: A 12-year-old boy with autism spectrum disorder presented at a follow-up visit with bilateral breast growth. There was a family history of gynecomastia, cataracts at a young age, puberty delay, and myotonic dystrophy type 1. The physical examination showed that he had bilateral gynecomastia with external genitalia Tanner stage 1. Neurologic examination was regular, without demonstrable myotonia. The analytical study revealed increased estradiol levels and estradiol/testosterone ratio. After excluding endocrine diseases, the molecular study of the dystrophia myotonica protein kinase gene confirmed the diagnosis of myotonic dystrophy type 1. Comments: A diagnosis of prepubertal gynecomastia should include an investigation for possible underlying diseases. This case report highlights the importance of considering the diagnosis of myotonic dystrophy type 1 in the presence of endocrine and neurodevelopmental manifestations.

RESUMO Objetivo: Apresentar o caso de um adolescente pré-púbere com ginecomastia bilateral e transtorno do espectro autista, diagnosticado com distrofia miotônica tipo 1. Descrição do caso: Adolescente do sexo masculino de 12 anos, com transtorno do espectro autista, observado em consulta de seguimento por crescimento mamário bilateral. O paciente tinha antecedentes familiares de ginecomastia, catarata em idade jovem, atraso pubertário e distrofia miotônica tipo 1. À observação física, apresentava ginecomastia bilateral estádio 1 de Tanner. O exame neurológico era normal, sem miotonia aparente. O estudo analítico mostrou níveis elevados de estradiol e da relação estradiol/testosterona. Após exclusão de causas endócrinas, o estudo molecular do gene DMPK confirmou o diagnóstico de distrofia miotônica tipo 1. Comentários: Perante um quadro de ginecomastia pré-púbere, deve-se excluir doenças subjacentes. Este caso reforça a importância de considerar o diagnóstico de distrofia miotônica tipo 1 na presença de manifestações endócrinas e do neurodesenvolvimento.

"Gymnastica e educação physica": saberes da educação física na escola normal, elementar e colégios distritais do Rio Grande do Sul, em fins do século XIX e início do século XX / "Gymnastica and educação physica": physical education knowledge at normal and elementary schools and at district schools of Rio Grande do Sul in the late 19th and early 20th centuries / "Gimnástica y educación física": saberes de la educación física en la escuela normal, básica y colegios distritales de Rio Grande do Sul, a fines del siglo XIX y principios del siglo XX

O presente estudo tem, por objetivo, compreender a presença da Gymnastica e da Educação Physica na formação de professores(as) primários(as) no Rio Grande do Sul, durante o período de 1877 a 1909. Para o alcance do objetivo proposto, analisamos a documentação legal do estado, especialmente aquela que previu orientações relacionadas às estruturas educacionais, expedidas no período de 1877 a 1909. A interpretação aos materiais de pesquisa, amparada pelos aportes teóricos da História das Disciplinas Acadêmicas e Escolares e dos Saberes Disciplinares, indicou que a inserção de conteúdos referentes à Gymnastica e à Educação Physica, nas grades de ensino, foi assumindo contornos mais amplos na realidade educacional sul-rio-grandense, especialmente naquela voltada à formação de professores(as). Desta forma, tais ampliações podem ter influenciado no estabelecimento de ações pioneiras levadas a efeito nos anos posteriores ao período investigado

This paper explores the role played by Gymnastics and Physical Education in the training of elementary school teachers in Rio Grande do Sul, Brazil, in 1877-1909. We analyzed the state's legal documents, especially those providing guidelines related to educational structures in the period. The interpretation of research materials, based on the theoretical contributions of History of Academic and School Disciplines and Disciplinary Knowledges, indicated that the inclusion of contents referring to Gymnastica and Educação Physica in the curriculum gained increasing importance in the state's educational scene, particularly regarding teacher training. Thus, that inclusion may have influenced the establishment of pioneering actions carried out in the years after the period investigated

Esta investigación objetiva comprender la presencia de la Gimnástica y la Educación Física en la formación de profesores de la enseñanza primaria en Rio Grande do Sul, Brasil, durante el periodo de 1877 a 1909. Para esto, analizamos los documentos legales del Estado mencionado, especialmente los que contenían las orientaciones relativas a las estructuras educativas en el periodo que va de 1877 a 1909. La interpretación de los materiales de investigación, amparada por los aportes teóricos de la Historia de las Disciplinas Académicas y Escolares y de los Saberes Disciplinarios, indicó que la inserción de contenidos relativos a la Gimnástica y a la Educación Física, en las estructuras curriculares, se fue perfilando más en la realidad educativa de Rio Grande do Sul, especialmente en lo que concierne a la formación de profesores y profesoras. De esta forma, tales ampliaciones pueden haber tenido influencia en el planteamiento de acciones pioneras llevadas a cabo en los años posteriores al período investigado

Ibuprofen-induced aseptic meningitis: a case report / Meningite asséptica induzida por ibuprofeno: um caso clínico

ABSTRACT Objective: To report a case of a male adolescent with the diagnosis of ibuprofen-induced meningitis. We discuss themain causes of drug-induced aseptic meningitis (DIAM) and highlight the importance of early recognition of DIAM, sothat the offending drug can be withdrawn, and recurrences prevented. Only few DIAM cases have been reported in pediatric age. Case description: A healthy 15-year-old boy presented to the emergency department with headache, nausea, dizziness, fever, conjunctival hyperemia and blurred vision 30 minutes after ibuprofen-intake. During his stay, he developed emesis and neck stiffness. Cerebrospinal fluid analysis excluded infectious causes, and DIAM was considered. He totally recovered after drug withdrawal. Comments: DIAM is a rare entity, that should be considered in the differential diagnosis of an aseptic meningitis. The major causative agents are nonsteroidal anti-inflammatory drugs, particularly ibuprofen. Suspicion is made by the chronologic link between drug intake and the beginning of symptoms, but infectious causes should always be ruled out.

RESUMO Objetivo: Descreve-se o caso de um adolescente do sexo masculino com diagnóstico de meningite asséptica por ibuprofeno. Discutem-se as causas de meningite asséptica induzida por medicamentos (MAIM) e a importância do reconhecimento precoce dessa situação, para que a medicação envolvida seja suspensa e as recorrências prevenidas. Poucos casos foram descritos em idade pediátrica. Descrição do caso: Adolescente de 15 anos, gênero masculino, saudável, procurou o serviço de urgência por cefaleia, náuseas, tonturas, febre, hiperemia conjuntival e visão desfocada 30 minutos após o uso de ibuprofeno. Durante a internação, iniciou vômitos e rigidez na nuca. A análise do líquido cefalorraquidiano excluiu causas infeciosas, e considerou-se como diagnóstico mais provável a MAIM. A recuperação foi total após a suspensão do medicamento. Comentários: A MAIM é rara, mas deve ser considerada no diagnóstico diferencial de meningite asséptica. A principal causa são os anti-inflamatórios não esteroides, principalmente o ibuprofeno. A suspeita clínica é evocada pela relação temporal entre o uso do medicamento e o início dos sintomas, mas as causas infeciosas devem ser sempre excluídas.