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Bioorg Med Chem Lett
; 25(7): 1455-9, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25770781
RESUMEN
A series of imidazo[1,2-a]indeno[1,2-e]pyrazin-4-ones that potently inhibit M. tuberculosis glutamine synthetase (GlnA1) has been identified by high throughput screening. Exploration of this series was performed owing to a short chemistry program. Despite possibly nanomolar inhibitions, none of these compounds was active on whole cell Mtb, suggesting that GlnA1 may not be a suitable target to find new anti-tubercular drugs.