Sebaceous carcinoma of the eyelid: anatomoclinical data.

Sebaceous gland carcinoma of the eyelid is a rare slow-growing tumor and is one of the most aggressive malignancies of the eyelid. Diagnosis is often delayed because it can be confused with other periocular lesions. We report the case of a 78-year-old female who presented for the anesthetic aspect of a nodular tumor on the right upper eyelid occurring one year earlier. The patient was treated for three months for recurrent chalazion. Ophthalmologic examination revealed a nodular ulcerated tumor of 1 cm in size adherent to adjacent tissues. Surgical excision was performed with a safety margin of 4 mm. The diagnosis of moderately differentiated sebaceous carcinoma was made by routine morphological methods and immunohistochemical reactions (EMA and Ki-67). Being a rare tumor with considerable morbidity and mortality, early diagnosis and proper treatment are essential for a favorable prognosis and preservation of visual function.

The correlation between anterior ischemic optic neuropathy the non-arthritic form, and the treatment involving alpha-interferon.

The anterior ischemic optic neuropathy is an uncommon complication of alpha-Interferon treatment, characterized by the either temporary or permanent diminishing in visual acuity. We are hereby presenting the clinical case of an anterior ischemic optic neuropathy (non-arteritic form) complicating interferon therapy for Chronic Hepatitis C. In such cases we recommend ophthalmological examinations and if severe ophthalmologic complications occur antiviral treatment should be stopped immediately.

[Morphopathological changes in glaucoma-induced trabecular meshwork]. / Modificarile morfopatologice ale retelei trabeculare în glaucom.

UNLABELLED: Glaucoma causes trabecular meshwork and Schlemm canal changes, resulting in the obstruction of the aqueous flow at this level. AIM: To show the histological changes in the surgically removed trabecular meshwork tissues. MATERIAL AND METHOD: Trabecular meshwork fragments were histologically processed for histological diagnosis. RESULTS: 29.87% of all patients had ordered structure with high eosinophilia, 20.12% a rare structure with high eosinophilia, 21.34% a voluminous trabecular meshwork with fusiform cells, 21.03% tissue fibrosis and 7.62% had tissue necrosis. CONCLUSIONS: Aqueous flow obstruction in trabecular meshwork is produced by the histological changes at this level, found in all tissue specimens removed during surgery.

[Chronic dacryocystitis fistulization in a Rubinstein-Taybi syndrome]. / Dacriocistita cronica fistulizata într-un caz de sindrom Rubinstein-Taybi.

The article presents the treatment difficulties of the chronic dacryocystitis at an eight month old patient, diagnosed with Rubinstein-Taybi syndrome. The difficulties occurred as a result of numerous antibiotic treatments and surgical procedures suffered by the patient since his second week of life.

[The retinal fold in premature infants]. / Studiul pliului retinian la prematuri.

More and more authors point out the existence of the retinal folds at the prematures with retrolental fibroplasia. This form is considered to be achieved. The survey has been done during 3 years on 27 children, divided in 2 groups: the former was the group of the prematures with retinal fold present in retrolental fibroplasia, and the later was the group of children with congenital retinal fold, but born at time. Clinically, the difference between the two types of folds is not so obvious, but from the morphoscopical aspect they differ. The therapy of the diagnosed children was the usual one done in complications: strabismus, cataract, retinal detachment. The conclusions is that, besides the malformative retinal fold of the child born at time, another similar lesion provoked by the prematurity and abusive oxygenation is possible.

Osteosarcoma of soft tissues. A case report.

The case of a 78-year old man with a non adherent subcutaneous tumour in the right iliac fossa was presented. In about one year and a half it stretched on the third superior part of the fore right thigh and appeared under the shape of a hard plate free from the osseous tissue. Microscopically, besides some fibrosarcomatous proliferations or very slightly differentiated ones with osteoid structures, the predominance of the osteosarcomatous images was found. The problems of pathogenesis and diagnosis of extraskeletal osteosarcomas were discussed.

Giant neurofibroma of the pectoral region including the breast. Case report.

A case of a 56 years old female patient with a giant tumour of the left pectoral region developed in a 2 years time was reported. The tumour, free from skin and pectoral muscles, was after mammectomy 25 x 15 x 5 cm, 2.200 grs, multilobaed, albescent with hemorrhages zones and predominantly hard, the rest of the breast being extremely reduced in comparison with the volume of the tumour itself. The initial histological aspect was that of a benign spindle cell tumour and only after some neurohistological techniques the diagnosis established was neurofibroma. The literature data and the exceptional mammary localization of this tumour were reviewed.

Uterine leiomyofibroma associated with mesodermal mixed tumour. Case report.

It was reported a case of a 55-year-old woman with giant uterine polylobated leiomyofibromatosis with an albescent-reddish fluctuating nodule, of a mesodermal heterologous mixed tumour aspect. The origin of these sarcomas from müllerian pluripotent mesenchymal cells is discussed. The particularity of this case is underlined by the association of two distinct types of benign and malignant tumours.

[Clinical and histopathologic polymorphism in cystic fibrosis]. / Polimorfism clinic si histopatologic în fibroza chistica.

After reviewing recent data concerning the pathologic physiology of cystic fibrosis the authors present an anatomoclinical study of 30 infants, of which 13 neonates, with a diagnosis of mucoviscidosiss, emphasizing the clinical and pathohistologic polymorphism of this affection, and, particularly involvement of the liver and intestines. Specific hepatic lesions were encountered in only 10% of the group studied (Bodian biliary cirrhosis and mucus stoppers in the bile ducts). Unspecific hepatic lesions were dominant, common with those of neonatal hepatitis, and hepatic steatosis. Stress is laid on the presence of atrophy of the villi in children with hepatic steatosis, proof of a lesional substrate of malabsorption in this disease. The authors note the early onset of hepatic lesions, the gravity of the cases with an early clinical expression and hepatic biopsy puncture as the only method revealing hepatic affection in cystic fibrosis. In the first semester of life there exists purely digestive forms, hepatic steatosis and oedematous dystrophy in infants at this age being highly suspect of the etiology.

Uncommon pneumonia associated with acute poststreptococcal glomerulonephritis.

184 cases of acute poststreptococcal glomerulonephritis were investigated and six of these were associated with a peculiar, uncommon pneumonia, and another one had a lethal course. The clinicoradiological and especially pathological data summarized in this study attempt to demonstrate the individuality of this type of pneumonia. Pneumonia associated with acute poststreptococcal glomerulonephritis is similar or identical to rheumatic pneumonia. In both entities, pneumonia and pulmonary edema may and do coexist, and the differentiation of pneumonia from congestive heart failure is difficult and often impossible without pathological evidence. The most attractive pathogenic interpretation is the hypothesis of an immune mechanism in the induction of pneumonia. Authors attributed the lung changes, consecutive to a vascular damage, to a hypersensitivity phenomenon, with accumulation of fibrinogen in alveoli where it is converted to fibrin. Then, the hyaline membrane lining the alveoli, an important feature of pneumonia associated with glomerulonephritis is built up. It is, however, plausible that the effect of the immune reaction is associated with those of hydrosaline retention, arterial hypertension and congestive heart failure. Analogous to rheumatic pneumonia, the "peculiar pneumonia" associated with acute poststreptococcal glomerulonephritis should be named nephritic pneumonia.