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1.
Preprint en Inglés | medRxiv | ID: ppmedrxiv-21268270

RESUMEN

ImportanceUniversal paid sick-leave (PSL) policies have been implemented in jurisdictions to mitigate the spread of SARS-CoV-2. However empirical data regarding health and economic consequences of PSL policies is scarce. ObjectiveTo estimate effects of a universal PSL policy in Ontario, Canadas most populous province. DesignAn agent-based model (ABM) to simulate SARS-CoV-2 transmission informed by data from Statistics Canada, health administrative sources, and from the literature. SettingOntario from January 1st to May 1st, 2021. ParticipantsA synthetic population (1 million) with occupation and household characteristics representative of Ontario residents (14.5 million). ExposureA base case of existing employer-based PSL alone versus the addition of a 3-or 10-day universal PSL policy to facilitate testing and self-isolation among workers infected with SARS-CoV-2 themselves or because of infected household members. Main Outcome(s) and Measure(s)Number of SARS-CoV-2 infections and COVID-19 hospitalizations, worker productivity, lost wages, and presenteeism (going to a workplace while infected). ResultsIf a 3- and 10-day universal PSL were implemented over the 4-month study period, then compared with the base-case, the PSL policies were estimated to reduce cumulative SARS-CoV-2 cases by 85,531 (95% credible interval, CrI -2,484; 195,318) and 215,302 (81,500; 413,742), COVID-19 hospital admissions by 1,307 (-201; 3,205) and 3,352 (1,223; 6,528), numbers of workers forgoing wages by 558 (-327;1,608) and 7,406 (6,764; 8,072), and numbers of workers engaged in presenteeism by 24,499 (216; 54,170) and 279,863 (262,696; 295,449). Hours of productivity loss were estimated to be 10,854,379 (10,212,304; 11,465,635) in the base case, 17,446,525 (15,934,321; 18,854,683) in the 3-day scenario, and 26,127,165 (20,047,239; 29,875,161) in the 10-day scenario. Lost wages were $5,256,316 ($4,077,280; $6,804,983) and $12,610,962 ($11,463,128; $13,724,664) lower in the 3 day and 10 day scenarios respectively, relative to the base case. Conclusions and RelevanceExpanded access to PSL is estimated to reduce total numbers of COVID-19 cases, reduce presenteeism of workers with SARS-CoV-2 at workplaces, and mitigate wage loss experienced by workers. Competing interestsThe authors have no competing interests relevant to this article to disclose. FundingSupported by COVID-19 Rapid Research Funding (C-291-2431272-SANDER). This research was further supported, in part, by a Canada Research Chair in Economics of Infectious Diseases held by Beate Sander (CRC-950-232429). The study sponsor had no role in the design, collection, analysis, interpretation of the data, manuscript preparation or the decision to submit for publication. Author ContributionsConceptualization: PP, JDR, BS, DN Data Curation: PP, JDR, BS, DN Formal Analysis: PP, JDR, DN Methodology: PP, JDR, BS, DN Supervision: PP, DN, BS Validation: PP, JDR, BS, DN First Draft: PP, JDR, BS, DN Review and Edit PP, JDR, BS, DN Key pointsO_ST_ABSQuestionC_ST_ABSWhat could be the health and economic consequence of more generous paid sick leave policies in the context of the COVID-19 pandemic? FindingsMore generous policies are estimated to reduce SARS-CoV-2 infections (and thus COVID-19 hospitalizations), lost wages and presence of individuals with infection at workplaces. MeaningMore generous paid sick leave can be a valuable addition to other COVID-19 public health interventions.

2.
Preprint en Inglés | medRxiv | ID: ppmedrxiv-20248166

RESUMEN

As the COVID-19 pandemic has progressed, more local data has become available, enabling a more granular modeling approach. In March 2020, we developed a COVID-19 Resource Estimator (CORE) model to estimate the acute care resource use in Ontario, Canada. In this paper, we describe the evolution of CORE2.0 to incorporate age, sex, and time-dependent acute care resource use, length of stay, and mortality to simulate hospital occupancy. Demographics (e.g., age and sex) of infected cases are informed by 4-month averages between March-June, and July-October using 10-year age groups. The probability of hospitalization, ICU admission, and requiring mechanical ventilation are all age and sex-dependent. LOS for each acute care level ranges from 5.7 to 16.15 days in the ward, 6.5 to 10.7 days in the ICU without ventilation, and 14.8 to 21.6 days on the ventilator, depending on month of infection. We calibrated some LOS components to reported ward and ICU occupancy between June 15 and October 31, 2020. Furthermore, we demonstrate the use of CORE2.0 for a regional analysis of Region of Waterloo, Ontario, Canada to simulate the ward bed, ICU bed, and ventilator occupancies for 30 days starting December 2020 for three case trajectory scenarios. Moving forward, this model has become highly flexible and customizable to data updates, and can better inform acute care planning and public measures as the pandemic progresses.

3.
Preprint en Inglés | medRxiv | ID: ppmedrxiv-20178434

RESUMEN

BackgroundPredicting potential healthcare resource use under different scenarios will help to prepare the healthcare system for a surge in COVID-19 patients. In this study, we aim to predict the effect of COVID-19 on hospital resources in Nigeria. MethodWe adopted a previously published discrete-time, individual-level, health-state transition model of symptomatic COVID-19 patients to the Nigerian healthcare system and COVID-19 epidemiology. We simulated different combined scenarios of epidemic trajectories and acute care capacity. Primary outcomes included expected cumulative number of cases, days until depletion resources, and number of deaths associated with resource constraints. Outcomes were predicted over a 60-day time horizon. ResultsIn our best-case epidemic trajectory, which implies successful implementation of public health measures to control COVID-19 spread, the current number of ventilator resources in Nigeria (conservative resources scenario), were expended within five days, and 901 patients may die while waiting for hospital resources in conservative resource scenario. In our expanded resource scenarios, ventilated ICU beds were depleted in all three epidemic trajectories within 60 days. Acute care resources were only sufficient in the best-case and intermediate epidemic scenarios, combined with a substantial increase in healthcare resources. ConclusionCurrent hospital resources are inadequate to manage the COVID-19 pandemic in Nigeria. Given Nigerias limited resources, it is imperative to increase healthcare resources and maintain aggressive public health measures to reduce COVID-19 transmission. KEY QUESTIONSO_ST_ABSWhat is already known on this subject?C_ST_ABSWhile western countries seem to be recovering from the COVID-19 pandemic, there is an increasing community spread of the virus in many African countries. The limited healthcare resources available in the region may not be sufficient to cope with increasing numbers of COVID-19 cases. What this study adds?Using the COVID-19 Resource Estimator (CORE) model, we demonstrate that implementing and maintaining aggressive public health measures to keep the epidemic growth at a low rate, while simultaneously substantially increasing healthcare resources is critical to minimize the impact of COVID-19 on morbidity and mortality. The impact of COVID-19 in low resource settings will likely overwhelm health system capacity if aggressive public health measures are not implemented. To mitigate the impact of COVID-19 in these settings, it is essential to develop strategies to substantially increase health system capacities, including hospital resources, personal protective equipment and trained healthcare personnel and to implement and maintain aggressive public health measures.

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