1.
Org Biomol Chem
; 20(25): 5050-5054, 2022 06 29.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35695066
RESUMEN
Alternapyrone is a highly methylated polyene α-pyrone biosynthesised by a highly reducing polyketide synthase. Mutations of the catalytic dyad residues, H1578A/Q and E1604A, of the C-methyltransferase domain resulted in either significantly reduced or no production of alternapyrone, indicating the importance of C-methylation for alternapyrone biosynthesis.