RESUMEN
BACKGROUND AND STUDY PURPOSE: to describe the comorbidity of celiac disease among a large cohort of multiple sclerosis patients in Tuscany. METHODS: the association of celiac disease among multiple sclerosis adult patients (n=2050) was retrospectively evaluated. RESULTS: 13 patients were diagnosed with celiac disease, the female:male ratio was 3.3:1 and the median age at diagnosis was 34.2 years (SD 13). Seventy-seven per cent of subjects complained about gastrointestinal symptoms. IgA anti- transglutaminase was positive in 85 % of cases and there was 70 % of villous atrophy. CONCLUSIONS: the frequency of celiac disease among multiple sclerosis patients examined was lower than in the general population, 0.6 % vs 1 %)(p = 0.65)
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Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Adulto , Persona de Mediana Edad , Esclerosis Múltiple/complicaciones , Enfermedad Celíaca/complicaciones , Estudios Retrospectivos , Comorbilidad , ItaliaAsunto(s)
Consenso , Enfermedades Desmielinizantes/diagnóstico , Enfermedades Desmielinizantes/terapia , Progresión de la Enfermedad , Enfermedades Desmielinizantes/diagnóstico por imagen , Enfermedades Desmielinizantes/fisiopatología , Humanos , Imagen por Resonancia Magnética , Esclerosis Múltiple/diagnóstico , Esclerosis Múltiple/fisiopatología , Esclerosis Múltiple/terapiaRESUMEN
The role of cognitive impairment in multiple sclerosis is now widely recognized. However, there is a dearth of research on variability and practice effects of neuropsychological measures when repeated over time. The objective was to assess reliability and practice effects for Rao's Brief Repeatable Battery of neurophysiological tests and the Stroop Test, and to provide data for correction for variability and practice effects in serial assessments.In 54 healthy controls (34 women, mean age 38.3 +/- 9.1 years, mean education 12.9 +/- 3.3 years), the Brief Repeatable Battery and Stroop Test were administered 3 times with an 18-month interval. Reliability was assessed by intraclass correlation coefficient and practice effects by an analysis of variance with Bonferroni's correction for repeated measures. Test-retest reliability was from adequate to good on the Symbol Digit Modalities Test, the Stroop Test, and the Paced Auditory Serial Addition Test. The great majority of tests showed at least a moderate practice effects. Data for calculation of an individual's change in cognitive performance for each test of the Brief Repeatable Battery and the Stroop Test were provided. Our results provide relevant information for planning and interpreting longitudinal studies on cognition and cognitive rehabilitation in multiple sclerosis.
