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1.
Br J Nurs ; 32(Sup20): S6-S10, 2023 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-37949489

RESUMEN

Treatment of infected wounds remains a major challenge for clinicians. Antimicrobial stewardship is an important pillar in wound treatment and, as the role of bacteria in wound repair is not well understood, new treatment options and products are constantly being developed to tackle local infection and biofilm. This case report describes a case of antibiotic-resistant Burkholderia cepacia skin infection and subsequent leg ulceration in an 86-year-old man during the COVID pandemic in Italy, which was successfully treated in a conservative way using 1% acetic acid and silver oxysalts in conjunction with compression bandage.


Asunto(s)
Burkholderia cepacia , Úlcera Cutánea , Masculino , Humanos , Anciano de 80 o más Años , Antibacterianos/uso terapéutico , Piel , Cicatrización de Heridas
2.
J Clin Med ; 12(14)2023 Jul 20.
Artículo en Inglés | MEDLINE | ID: mdl-37510901

RESUMEN

BACKGROUND: Ischemia/reperfusion injury (IRI), acute rejection (AR), and delayed graft function (DGF) might occur as major complications following kidney transplantation. Thus, the identification of biomarkers for the IRI, AR, and/or DGF development becomes crucial as it may help to guide post-transplant management. Natural killer (NK) cells, hepatic interstitial T-lymphocytes (T-Li), and NK-T cells are crucial in both innate and adaptive immunity after abdominal solid organ transplantation. Hence, the aim of this study was to evaluate the impact of the immune system after graft reperfusion during KT in adults in order to identify predictive biomarkers. METHODS: The NK, T-Li, and NK-T phenotypes and concentrations were retrospectively analyzed in a consecutive series of liver perfusates obtained after organ procurement flushing the abdominal cavity recovered from deceased brain donors (DBDs). Their percentage was compared with the renal transplant recipients' characteristics with kidneys taken from the same DCDs. The hepatic perfusate cells were purified by density gradient centrifugation. Flow cytometric investigation was used to determine their phenotype with the following immunological markers in order to determine the relative percentage of T-Li, NK-T, and NK cells: CD3, CD4, CD8, and CD56. RESULTS: 42 DBDs' liver perfusates were analyzed. The related clinical outcomes of kidney transplant recipients from 2010 to 2020 performed at our Institute were evaluated. Time in days of delayed functional recovery of transplanted kidneys (DGF) (p = 0.02) and the onset of secondary infection from a cytomegalovirus (p = 0.03) were significantly associated with the T-Li percentage. An increased relative risk (HR) of organ survival was significantly associated with the percent cell concentration of T-Li and time to DGF, on COX analysis, were (HR = 1.038, p = 0.04; and HR = 1.029, p = 0.01, respectively). None relevant clinical outcomes in kidney transplant patients were associated with the specificity of the NK and NK-T cell proportions. CONCLUSIONS: A new potential role of T-Li cells was detected in the context of hepatic perfusate from DBDs. It could detect potential impacts in organ allocation, surgical procuring techniques, and in the analysis of IRI pathophysiological events.

3.
G Ital Cardiol (Rome) ; 24(5): 344-354, 2023 May.
Artículo en Italiano | MEDLINE | ID: mdl-37102347

RESUMEN

The aim of this paper is to present the diagnostic and therapeutic care pathway on peripheral arterial disease, recently developed in the Piedmont Region, Italy. It proposes a combined approach between the cardiologist and vascular surgeon for optimizing the treatment of patients with peripheral artery disease, which includes the most recently approved antithrombotic and lipid-lowering drugs. The goal is to promote a greater awareness on peripheral vascular disease, in order to implement its treatment patterns and consequently to perform an effective secondary cardiovascular prevention.


Asunto(s)
Fibrinolíticos , Enfermedad Arterial Periférica , Humanos , Fibrinolíticos/uso terapéutico , Vías Clínicas , Enfermedad Arterial Periférica/diagnóstico , Enfermedad Arterial Periférica/tratamiento farmacológico , Hipolipemiantes/uso terapéutico , Lípidos
4.
Catheter Cardiovasc Interv ; 98(1): E115-E121, 2021 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-33893754

RESUMEN

BACKGROUND: While the experience with PCSK9i in patients with coronary artery disease has been wide, and coronary plaque regression has been documented, little is known regarding the role of these drugs on carotid plaque regression. The CARotid plaqUe StabilizatiOn and regression with evolocumab (CARUSO) study is a randomized, single-center, investigator-initiated trial aiming at evaluating carotid plaque morphological stabilization and regression following, respectively, 6 and 12 months of therapy with evolocumab. METHODS: Asymptomatic patients with uni- or bilateral de novo carotid artery stenosis ≥50% and LDL-C values ≥100 mg/dl despite maximum tolerated lipid lowering therapy (LLT) will be randomized to evolocumab 140 mg s.c. every 2 weeks on top of ongoing LLT, or no additional treatment. 100 patients (50 in each arm) will be enrolled. Serial carotid duplex ultra-sonography will be performed to monitor the carotid plaque morphology and stenosis over time. RESULTS: The primary end point of the study is, (a) carotid plaque morphological stabilization at 6 months, defined as defined as the disappearance of ulcerations and fluffy components and the achievement of a regular plaque morphology with prevalence of fibrous atheroma and/or (b) carotid plaque regression at 12 months, defined as reduction of the entity of the stenosis and/or peak systolic velocity by at least 5%, as compared with baseline. CONCLUSION: The CARUSO trial will test the superiority of evolocumab on top of ongoing LLT versus ongoing LLT alone regarding carotid plaque morphological stabilization and regression. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.


Asunto(s)
Estenosis Carotídea , Placa Aterosclerótica , Anticuerpos Monoclonales Humanizados , Arterias Carótidas , Estenosis Carotídea/diagnóstico por imagen , Estenosis Carotídea/tratamiento farmacológico , Humanos , Placa Aterosclerótica/tratamiento farmacológico , Resultado del Tratamiento
5.
Transplant Proc ; 51(9): 2910-2913, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31606181

RESUMEN

INTRODUCTION: Laparoscopic living donor nephrectomy (LLDN) has become the standard procedure for living kidney transplantation. Enhanced recovery after surgery (ERAS) is a multimodal perioperative management aimed at facilitating rapid patient recovery after major surgery by modifying the response to stress induced by exposure to surgery. This association can further reduce hospital stay, surgical stress, and perioperative morbidity of living kidney donors. MATERIAL AND METHODS: In this retrospective analysis conducted at our institute, we compared the first 21 patients who underwent LLDN enrolled with the ERAS protocol with 55 patients who underwent LLDN with the fast-track protocol in the 5 years prior to ERAS protocol implementation. RESULTS: We evaluated 76 consecutive patients. After ERAS protocol implementation, elderly living donors had a shorter hospital stay and a faster return to normal life compared with the same age group of patients in the previous period. There were no major differences in median postoperative hospital stay and no meaningful differences in the percentage of complications after surgery and hospital readmissions. CONCLUSIONS: The introduction of the ERAS protocol for patients undergoing LLDN compared with the traditional protocol led to a reduction in postoperative hospitalization in elder donors, without determining a raise in the number of hospital complications and readmissions.


Asunto(s)
Trasplante de Riñón , Donadores Vivos , Nefrectomía/métodos , Recuperación de la Función , Recolección de Tejidos y Órganos/métodos , Adulto , Anciano , Femenino , Humanos , Laparoscopía/efectos adversos , Laparoscopía/métodos , Tiempo de Internación/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Readmisión del Paciente/estadística & datos numéricos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Estudios Retrospectivos , Recolección de Tejidos y Órganos/efectos adversos
6.
Transplant Proc ; 51(9): 2868-2872, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31606187

RESUMEN

BACKGROUND: The gap between organ availability and patients on the waiting list for deceased donor kidney transplants has resulted in the wide use of extended criteria donors (ECDs).We aimed to compare the surgical outcomes of single kidney transplantation (KT) performed at our institute with standard criteria donor (SCD) or ECD grafts, according to the Organ Procurement and Transplantation Network definition. PATIENTS AND METHODS: Our retrospective analysis studied 115 adult recipients of KT from January 2016 to July 2018, with kidney grafts procured from adult donors after brain or circulatory death, performed at our institute. Among the 2 recipients' groups, we compared the incidence of early graft loss, delayed graft function, hospitalization, and surgical complications. We compared the evaluation of time to early graft loss with Kaplan-Meier estimators and curves; the hypothesis of no difference in time to graft loss between the 2 groups was tested using the log-rank statistics. RESULTS: Of the 103 deceased donor kidney transplants during the study period, 129 grafts were used after the regional network sharing allocation. More frequently, ECDs had a greater body mass index than SCDs (25.2 ± 3.9 vs 27.7 ± 5.0, P = .005) and type II diabetes mellitus (0% vs 18%, P = .002). KT recipients who received an ECD graft (73, 63.5%) were older (59.8 ± 9.8 vs 45.2 ± 15.4, P < .001) and presented a higher rate of delayed graft function (56% vs 24%, P = .001). Post-transplant graft loss did not differ among the 2 groups. CONCLUSION: Based on clinical experience in a single transplant center, ECD use for KTs is crucial in facing the organ shortage, without impairing post-deceased donor kidney transplant outcomes.


Asunto(s)
Trasplante de Riñón/métodos , Donantes de Tejidos/provisión & distribución , Obtención de Tejidos y Órganos/métodos , Adulto , Funcionamiento Retardado del Injerto/epidemiología , Femenino , Supervivencia de Injerto , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Grupos Raciales , Estudios Retrospectivos , Análisis de Supervivencia , Resultado del Tratamiento
7.
J Nanosci Nanotechnol ; 19(8): 4677-4685, 2019 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-30913768

RESUMEN

In this paper, we report a detailed study on the synthesis of composite nanowires of Pb-PbOHCl via galvanic deposition into the pores of a membrane acting as a template. PbOHCl deposition quantitatively occurs as the solution pH exceeds the value of about 4.12. Simultaneously, owing to the galvanic coupling, electro-deposition of lead occurs, so composite nanowires were formed. The role of different parameters controlling the kinetic evolution of the process, such as oxygen bubbling, solution pH, surface area and type of sacrificial anode were investigated one at a time. The results suggest that every modification accelerating the alkalization of the solution inside the template pores favors growth of composite nanowires richer in PbOHCl. Alumina and polycarbonate membranes were investigated as template, and the best results were obtained for polycarbonate membrane, which can be easily removed by dissolution in CHCl3 avoiding the collapse and successive loss of the nanowires.

8.
ACS Biomater Sci Eng ; 5(4): 1715-1724, 2019 Apr 08.
Artículo en Inglés | MEDLINE | ID: mdl-33405548

RESUMEN

A galvanic method to deposit chitosan coatings on stainless steel substrate is reported. Deposition of suitable coatings is desired to improve biocompatibility and corrosion resistance of metallic medical devices to be implanted in human body. In the present work, a thin hydrogel layer of chitosan was deposited on 304SS by a galvanic displacement reaction, which is advantageous first as it does not require external power supply. 304SS was immersed into an aqueous solution of chitosan/lactic acid and electrochemically coupled with magnesium acting as a sacrificial anode. SEM images showed the formation of a uniform layer of chitosan with a thickness controlled by deposition time. Corrosion tests in simulating body fluid showed that chitosan coatings shift the corrosion potential of 304 substrates toward nobler values. Finally, the cytotoxicity of the coating was investigated through cell viability assays with osteoblastic cell MC3T3-E1. The results revealed highly satisfying biocompatibility of the coating.

9.
Mater Sci Eng C Mater Biol Appl ; 64: 93-101, 2016 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-27127032

RESUMEN

In this work, brushite and brushite/hydroxyapatite (BS, CaHPO4·H2O; HA, Ca10(PO4)6(OH)2) coatings were deposited on 316L stainless steel (316LSS) from a solution containing Ca(NO3)2·4H2O and NH4H2PO4 by a displacement reaction based on a galvanic contact, where zinc acts as sacrificial anode. Driving force for the cementation reaction arises from the difference in the electrochemical standard potentials of two different metallic materials (316LSS and Zn) immersed in an electrolyte, so forming a galvanic contact leading to the deposition of BS/HA on nobler metal. We found that temperature and deposition time affect coating features (morphology, structure, and composition). Deposits were characterized by means of several techniques. The morphology was investigated by scanning electron microscopy, the elemental composition was obtained by X-ray energy dispersive spectroscopy, whilst the structure was identified by Raman spectroscopy and X-ray diffraction. BS was deposited at all investigated temperatures covering the 316LSS surface. At low and moderate temperature, BS coatings were compact, uniform and with good crystalline degree. On BS layers, HA crystals were obtained at 50°C for all deposition times, while at 25°C, its presence was revealed only after long deposition time. Electrochemical studies show remarkable improvement in corrosion resistance.


Asunto(s)
Fosfatos de Calcio/química , Durapatita/química , Técnicas Electroquímicas , Acero Inoxidable/química
10.
Ann Vasc Surg ; 28(1): 227-38, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-24011816

RESUMEN

BACKGROUND: Large randomized controlled trials have shown that carotid endarterectomy (CEA) is beneficial in the treatment of recent severe symptomatic carotid stenosis. Data are lacking concerning the risks of early CEA (<48 hours) for stroke in evolution (SIE) or crescendo transient ischemic attack (CTIA). The primary end point of this retrospective study was to evaluate the incidence of stroke, major adverse cardiac events (MACEs), and death within the first 30 days after early CEA performed within 48 hours in patients presenting with transient ischemic attack (TIA)/SIE. METHODS: Between 2001 and 2010, we treated 3,023 carotid artery stenoses, 29.5% (891/3,021) of which were in symptomatic patients. Early CEA within 48 hours after acute TIA/SIE was performed in 176 patients. Patients were divided into 3 groups for analysis of outcome after early CEA in symptomatic patients according to their initial neurologic deficit. Group 1 included 55 patients with TIA (single); group 2 included 55 patients with CTIA, and group 3 included 66 patients with SIE. Carotid artery stenosis was evaluated by duplex ultrasonography (DS). All patients were pre- and postoperatively visited by an experienced consultant neurologist who evaluated the neurologic status according to the modified Rankin Scale and the National Institutes of Health Stroke Scale (NIHSS). At admission, surgery was not performed on patients with disabling neurologic deficit (NIHSS score: >6) except for 4 selected cases (NIHSS score range: 8-14), patients with cerebral lesions >3 cm in diameter, patients with the presence or suspicion of parenchymal hemorrhage, patients with occlusion of the middle cerebral artery, and those who were deemed unfit for surgery. Clinical and DS follow-up examinations were performed after 6 and 12 months and annually thereafter. The mean duration of follow-up was 29.4 months (range: 0-120 months). RESULTS: The cumulative TIA/stroke/myocardial infarction/death rate at 30 days was 3.9% (7/176). TIA and stroke rates were 0% (0/176) and 3.4% (6/176), respectively. The stroke rate in groups 1, 2, and 3 was 1.8% (1/55), 0% (0/55), and 7.6% (5/66), respectively. No hemorrhagic strokes, TIAs, or MACEs were detected after surgery. Stroke risk was higher in group 3 than in groups 1 or 2, but the differences in the 3 groups were not statistically significant (group 1 vs. group 2: 1/55 vs. 0/55 events [P = 0.3151]); group 1 vs. group 3: 1/55 vs. 5/66 events [P = 0.3020]; and group 2 vs. group 3: 0/55 vs. 5/66 events [P = 0.1039]. Thirty-day follow-up was available for all patients, while long-term follow-up (mean: 32.7 ± 26.8 months) was available only for 158 patients (1 patient died and 17 were lost to follow-up). CONCLUSIONS: CEA can be performed with an acceptable risk in properly selected symptomatic patients within 48 hours after TIA or SIE. The benefits of early CEA in symptomatic patients include the prevention of recurrent stroke.


Asunto(s)
Estenosis Carotídea/cirugía , Endarterectomía Carotidea , Ataque Isquémico Transitorio/etiología , Accidente Cerebrovascular/etiología , Estenosis Carotídea/complicaciones , Estenosis Carotídea/diagnóstico , Estenosis Carotídea/mortalidad , Evaluación de la Discapacidad , Endarterectomía Carotidea/efectos adversos , Endarterectomía Carotidea/mortalidad , Humanos , Ataque Isquémico Transitorio/diagnóstico , Ataque Isquémico Transitorio/mortalidad , Ataque Isquémico Transitorio/prevención & control , Examen Neurológico , Selección de Paciente , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Prevención Secundaria , Índice de Severidad de la Enfermedad , Accidente Cerebrovascular/diagnóstico , Accidente Cerebrovascular/mortalidad , Accidente Cerebrovascular/prevención & control , Factores de Tiempo , Resultado del Tratamiento
11.
Ann Vasc Surg ; 27(7): 856-64, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23790763

RESUMEN

BACKGROUND: The endovascular treatment of an abdominal aortic aneurysm (AAA) is a treatment with low risk and good reported results. This retrospective study analyzed experience with patients requiring surgical conversion after endovascular abdominal aortic aneurysm repair (EVAR). METHODS: A total of 26 patients underwent open conversion (OC) after EVAR (18 endografts implanted at the authors' center and 8 in other centers). Patients were divided into 2 groups: early conversion if OC was performed within 30 days from the primary EVAR, and late conversion if OC was performed at least 30 days after EVAR. The authors analyzed all data on OC and the postoperative course. RESULTS: In this series, OC was performed for 22 endoleaks (13 type I, 5 type II, 2 type III, and 2 type V, which in 5 cases these were associated with AAA ruptures), 2 renal artery coverages, and 2 endograft infections. Six (23%) patients underwent early conversion with a mortality rate of 50%, and 20 (77%) had late conversion with a mortality rate of 20%. The overall mortality rate after OC, occurring before hospital discharge or within 30 days, was 26.9% (7 of 26). CONCLUSIONS: Endoleaks remain the weak point of endografts and can result in aneurysm rupture/death. Urgent OC and infections engender a high mortality. Elective OC can be performed with very low mortality and acceptable morbidity. Lifelong surveillance is necessary to detect and treat endoleaks.


Asunto(s)
Aneurisma de la Aorta Abdominal/cirugía , Rotura de la Aorta/cirugía , Implantación de Prótesis Vascular , Endofuga/cirugía , Procedimientos Endovasculares/efectos adversos , Anciano , Anciano de 80 o más Años , Aneurisma de la Aorta Abdominal/diagnóstico , Aneurisma de la Aorta Abdominal/mortalidad , Rotura de la Aorta/diagnóstico , Rotura de la Aorta/etiología , Rotura de la Aorta/mortalidad , Implantación de Prótesis Vascular/efectos adversos , Implantación de Prótesis Vascular/mortalidad , Distribución de Chi-Cuadrado , Procedimientos Quirúrgicos Electivos , Urgencias Médicas , Endofuga/diagnóstico , Endofuga/etiología , Endofuga/mortalidad , Procedimientos Endovasculares/mortalidad , Femenino , Mortalidad Hospitalaria , Humanos , Italia , Masculino , Persona de Mediana Edad , Reoperación , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento
12.
Ann Vasc Surg ; 26(2): 277.e1-3, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22079463

RESUMEN

A 48-year-old woman was referred to us for a pulsatile and painful mass on the right leg after a trauma occurred 2 months earlier. The duplex scan revealed the presence of an aneurysm of the perforating peroneal artery. The patient underwent an endovascular coil embolization of the aneurysm. The duplex-scan follow-up showed the patency of the peroneal vessel and the complete aneurysm thrombosis. The patient was discharged in good condition without pain. In literature, only four cases of aneurysm of perforating peroneal artery aneurysm, all with a clear traumatic etiology, are reported. In this case, the endovascular treatment was safe and effective.


Asunto(s)
Aneurisma/etiología , Extremidad Inferior/irrigación sanguínea , Lesiones del Sistema Vascular/etiología , Heridas no Penetrantes/etiología , Aneurisma/diagnóstico , Aneurisma/terapia , Arterias/lesiones , Embolización Terapéutica , Femenino , Humanos , Persona de Mediana Edad , Resultado del Tratamiento , Ultrasonografía Doppler Dúplex , Lesiones del Sistema Vascular/diagnóstico , Lesiones del Sistema Vascular/terapia , Heridas no Penetrantes/diagnóstico , Heridas no Penetrantes/terapia
13.
Ann Vasc Surg ; 25(8): 1142.e1-5, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22023952

RESUMEN

Aortoesophageal fistula is rare but fatal if untreated. Open thoracic surgery is associated with high operative mortality and morbidity. We report a case of a 77-year-old man who, treated with thoracic endovascular aortic repair (TEVAR) for descending thoracic aneurysm in another center, after an acute episode of hematemesis and melena was referred to our center. The total body computed tomography scan showed the presence of reperfusion of the descending thoracic aneurysm sac (8.8 cm in diameter) in the proximal and distal TEVAR landing zone (endoleak type I) without clear signs of fistulous tract with the esophageal lumen. The patient underwent new TEVAR inside previous implantation with proximal landing very close to left subclavian artery and distal landing just above celiac trunk. For the presence of a tracheoesophageal fistula, an esophageal endoprosthesis was implanted few days later, and a jejunostomy was performed. At 30 days, patient was in good general condition, but he died at 3 months' follow-up. Aortoesophageal fistula is a rare and usually fatal condition; early recognition and TEVAR treatment prevent immediate exsanguination in patients, but after deployment of the endograft, most patients are at risk for infectious complications. Cessation of bleeding and restoration of circulation is of paramount urgency, but infectious diseases and esophageal repair remain open problems.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Enfermedades de la Aorta/cirugía , Implantación de Prótesis Vascular/efectos adversos , Errores Diagnósticos , Procedimientos Endovasculares , Fístula Esofágica/cirugía , Neoplasias Esofágicas/diagnóstico , Fístula Traqueoesofágica/cirugía , Fístula Vascular/cirugía , Anciano , Enfermedades de la Aorta/diagnóstico , Enfermedades de la Aorta/etiología , Aortografía/métodos , Procedimientos Endovasculares/instrumentación , Fístula Esofágica/diagnóstico , Fístula Esofágica/etiología , Resultado Fatal , Humanos , Yeyunostomía , Masculino , Diseño de Prótesis , Reoperación , Tomografía Computarizada por Rayos X , Fístula Traqueoesofágica/diagnóstico , Fístula Traqueoesofágica/etiología , Resultado del Tratamiento , Fístula Vascular/diagnóstico , Fístula Vascular/etiología
14.
Ann Vasc Surg ; 25(7): 981.e7-11, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21665424

RESUMEN

Five patients were treated for ruptured visceral artery aneurysms during the last 9 years, including two splenic and three pancreaticoduodenal aneurysms. The average size of aneurysm was 2.6 cm (range: 1.5-5 cm). All patients underwent open surgical treatment. There was one operative death. After a mean follow-up of 46.6 months, there were no cases of mortality or secondary complications. The authors conclude that operative treatment of ruptured visceral artery aneurysms is durable.


Asunto(s)
Aneurisma Roto/cirugía , Procedimientos Quirúrgicos Vasculares , Vísceras/irrigación sanguínea , Adulto , Anciano , Aneurisma Roto/diagnóstico por imagen , Aneurisma Roto/mortalidad , Arterias/cirugía , Embolización Terapéutica , Femenino , Humanos , Ligadura , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares/efectos adversos , Procedimientos Quirúrgicos Vasculares/mortalidad
15.
Ann Vasc Surg ; 25(7): 982.e11-4, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21680145

RESUMEN

A 69-year-old man was referred to our facility owing to the sudden onset of a compression-like pain in the right leg, without limb-threatening acute ischemia. The duplex scan examination, followed by a selective leg angiography, showed the presence of a peroneal artery aneurysm. A diagnosis of mycotic aneurysm was made on the basis of the patient's clinical condition, positive blood cultures, and the unusual location of the lesion. Endovascular repair was performed by using a coil embolization and covered stent release. The patient was discharged in good general condition with complete pain relief. In previously published data, only four cases of peroneal artery aneurysm with a mycotic etiology have been reported. In this case, the endovascular treatment was safe and resolutive.


Asunto(s)
Aneurisma Infectado/terapia , Embolización Terapéutica , Endocarditis Bacteriana/microbiología , Procedimientos Endovasculares , Extremidad Inferior/irrigación sanguínea , Streptococcus mitis/aislamiento & purificación , Anciano , Aneurisma Infectado/diagnóstico , Aneurisma Infectado/microbiología , Antibacterianos/uso terapéutico , Arterias/microbiología , Endocarditis Bacteriana/complicaciones , Endocarditis Bacteriana/diagnóstico , Endocarditis Bacteriana/cirugía , Procedimientos Endovasculares/instrumentación , Humanos , Masculino , Stents , Ultrasonografía Doppler Dúplex
17.
Ann Vasc Surg ; 25(6): 805-12, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21621967

RESUMEN

BACKGROUND: Free-floating thrombus in the internal carotid artery (FFT-ICA) is a rare condition and its real incidence is unknown. The most common etiology is a complication of an atherosclerotic plaque, but several medical conditions can be responsible. The purpose of this study was to retrospectively analyze our experience with carotid endarterectomy in the management of FFT-ICA and also to analyze the patient outcome. METHODS: A retrospective review was performed of all patients admitted during the past 9 years with a diagnosis of FFT-ICA. Patient demographics, clinical manifestations, diagnostic modalities, surgical indications, operative details, postoperative courses, and follow-up information were recorded from the hospital database. RESULTS: Between January 2000 and December 2008, in our Unit, 2,572 carotid endarterectomies were performed for carotid artery disease. A total of 16 patients (16 of 2,572; 0.62%) were treated for an FFT-ICA. In all, 87.5% (14 of 16) of patients had neurological symptoms. All patients underwent a duplex scan. In 75% (12 of 16) of cases, additional diagnostic tests were performed: digital subtraction angiography (DSA), magnetic resonance angiography, or computed tomographic scan. Duplex scan and DSA detected the FFT-ICA in 62.5% and 100% of cases, respectively. Computed tomographic scan and magnetic resonance angiography failed to provide a diagnosis in majority of the patients (33.4% and 66.7%, respectively). The presence of FFT-ICA was confirmed intraoperatively in all cases. The cumulative stroke rate after surgery was 6.3% (one of 16). Of the total number of patients discharged, 68.75% showed an improvement of neurological symptoms, 12.5% were asymptomatic, 12.5% had no changes in symptoms, and 6.25% of cases worsened. At 30-day follow-up, the survival rate was 93.7% and 75% of patients showed an improvement of neurological symptoms, 12.5% were asymptomatic, and 6.25% died. In all, 6.25% of patients were lost to follow-up. CONCLUSION: Patients with FFT-ICA are usually symptomatic and present with an acute emergency. DSA remains the gold standard diagnostic test in FFT-ICA detection. We cannot assert that early surgery is superior to temporary anticoagulation and/or delayed intervention because of the absence of a comparison group. However, our retrospective results suggest that prompt intervention seems to be a safe alternative in FFT-ICA treatment.


Asunto(s)
Enfermedades de las Arterias Carótidas/diagnóstico , Enfermedades de las Arterias Carótidas/cirugía , Arteria Carótida Interna/cirugía , Endarterectomía Carotidea , Trombosis/diagnóstico , Trombosis/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Angiografía de Substracción Digital , Enfermedades de las Arterias Carótidas/mortalidad , Arteria Carótida Interna/diagnóstico por imagen , Arteria Carótida Interna/patología , Endarterectomía Carotidea/efectos adversos , Endarterectomía Carotidea/mortalidad , Femenino , Humanos , Italia , Angiografía por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Accidente Cerebrovascular/etiología , Tasa de Supervivencia , Trombosis/mortalidad , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Ultrasonografía Doppler Dúplex
18.
Ann Vasc Surg ; 24(7): 890-9, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20831991

RESUMEN

BACKGROUND: The early risk of stroke after transient ischemic attack (TIA)/stroke is of the order of 5-10% at 1 week and 10-20% at 3 months. Even if carotid endarterectomy (CEA) is the treatment of choice in symptomatic internal carotid artery stenosis, the timing of carotid intervention after acute stroke is not yet codified. The authors want to determinate whether early CEA is safely carried out in the first few hours (<48 hours) successive to the nondebilitating neurological event and whether the outcome (TIA/stroke/death) in these cases is comparable with the results of those treated by delayed/deferred surgery (range, 48 hours-24 weeks). METHODS: In 4 years, the authors performed 1,184 CEA (285 symptomatic). Five groups were formed from 285 symptomatic patients, according to interval between TIA/stroke onset and performance of CEA: G1, less than 48 hours; G2, 48 hours-2 weeks; G3, 2-4 weeks; G4, 4-8 weeks; G5, 8-24 weeks. Surgery was never performed on patients with disabling neurological deficit (modified Rankin Scale, 5) at the time of admittance, cerebral lesions greater than 3 cm at magnetic resonance/computed tomography scan, presence or suspect of parenchymal hemorrhage associated with ischemic damage, condition considered unfit for surgery (American Society of Anesthesiology classification grade V), and occlusion of the cerebral middle artery. Neurological and diagnostic examinations (duplex-scanning and computed tomography/magnetic resonance scan) were used in determining the selection for early CEA. RESULTS: Cumulative TIA/stroke/death rate after CEA was 3.8% (11/285) and at 30 days was 2.8% (8/285). The cumulative TIA rate after CEA and at 30 days was 0% (0/285). The cumulative stroke rate after CEA was 3.5% (10/285) and at 30 days was 2.4% (7/285). The cumulative death rate after CEA and at 30 days was 0.3% (1/285). Stroke rate after CEA in each group was: G1 4.2% (3/70); G2 3.2% (2/61); G3 0% (0/22); G4 3.4% (1/29); G5 3.8% (4/103). Any statistically significant difference between G1 and the other four groups was not detected with regard to postoperative stroke: G1 (4.2%) versus G2 (3.2%), p = 0.7641; G1 (4.2%) versus G3 (0%), p = 0.7648; G1 (4.2%) versus G4 (3.4%), p = 0.8473; G1 (4.2%) versus G5 (3.8%), p = 0.8952. No hemorrhagic stroke was detected after early CEA. The type of anesthesia and the use of a shunt didn't show any significant difference between the five groups. CONCLUSIONS: The analysis of these records suggests that early CEA in the acute post stroke phase, for patients clinically selected, does not result in greater complications than when performed delayed or deferred . Furthermore, the advantage of early CEA is the reduction of recurrent strokes, as untreated patients present a higher incidence of neurological events.


Asunto(s)
Isquemia Encefálica/etiología , Estenosis Carotídea/cirugía , Endarterectomía Carotidea , Accidente Cerebrovascular/etiología , Isquemia Encefálica/diagnóstico , Isquemia Encefálica/mortalidad , Estenosis Carotídea/complicaciones , Estenosis Carotídea/diagnóstico , Estenosis Carotídea/mortalidad , Distribución de Chi-Cuadrado , Endarterectomía Carotidea/efectos adversos , Endarterectomía Carotidea/mortalidad , Humanos , Italia , Imagen por Resonancia Magnética , Selección de Paciente , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Accidente Cerebrovascular/diagnóstico , Accidente Cerebrovascular/mortalidad , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Ultrasonografía Doppler Dúplex
19.
Ann Vasc Surg ; 24(8): 1034-7, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20800430

RESUMEN

BACKGROUND: This sequential retrospective monocentric study compares the results between general and local anesthesia for carotid endarterectomy (CEA). METHODS: Between November 2002 and October 2004, 428 CEAs were performed in our vascular unit. Two groups were formed: group GA (general anesthesia): 219 patients operated under general anesthesia; group LA (local anesthesia): 209 patients operated under local anesthesia. RESULTS: No mortality was found in both groups. After surgery, three strokes were detected in group GA and three in group LA (GA 1.36% vs. LA 1.43%, p = .9540); After CEA, there were three TIAs in GA group and none in LA group (GA 0.42% vs. LA 0%, p = .2634). CONCLUSION: The morbi-mortality was not influenced by the type of anesthesia used for carotid surgery. No statistical difference was detected in the perioperative neurological and cardiopulmonary complication rates between GA and LA.


Asunto(s)
Anestesia General , Anestesia Local , Estenosis Carotídea/cirugía , Endarterectomía Carotidea , Anciano , Anestesia General/efectos adversos , Anestesia Local/efectos adversos , Distribución de Chi-Cuadrado , Endarterectomía Carotidea/efectos adversos , Femenino , Humanos , Ataque Isquémico Transitorio/etiología , Italia , Masculino , Selección de Paciente , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Accidente Cerebrovascular/etiología , Resultado del Tratamiento
20.
Ann Vasc Surg ; 24(8): 1134.e9-13, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20599343

RESUMEN

True aneurysms of tibial artery are rare occurrences and their rupture is really rare. We report the case of a 59-year-old man who, after an episode of bacterial endocarditis, presented a posterior tibial aneurysm formation evolved in rupture. To our knowledge, this is the first case of a true giant aneurysm rupture of the posterior tibial artery (diameter, 6 cm). The treatment consisted of aneurysmectomy and surgical arterial ligation. A follow-up of 24 months was performed with good results.


Asunto(s)
Aneurisma Infectado/complicaciones , Aneurisma Roto/etiología , Arterias Tibiales , Aneurisma Infectado/diagnóstico , Aneurisma Infectado/cirugía , Aneurisma Roto/diagnóstico , Aneurisma Roto/cirugía , Antibacterianos/uso terapéutico , Humanos , Ligadura , Masculino , Persona de Mediana Edad , Arterias Tibiales/diagnóstico por imagen , Arterias Tibiales/cirugía , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Ultrasonografía Doppler en Color , Procedimientos Quirúrgicos Vasculares
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