RESUMEN
BACKGROUND: Renal impairment is common, affecting around 40% of acutely ill medical patients, and is associated with an increased risk of both venous thromboembolism (VTE) and bleeding. The clinical benefit of effective thromboprophylactic strategies may be outweighed in these patients by an excessive rate of hemorrhage. OBJECTIVE: To assess the safety and efficacy of lower prophylactic doses of fondaparinux in acutely ill medical patients with renal impairment. PATIENTS/METHODS: We carried out a multicenter, investigator-initiated, prospective cohort study. Patients at risk of VTE with a creatinine clearance between 20 and 50 mL min(-1) were treated with fondaparinux 1.5 mg qd for a minimum of 6 to a maximum of 15 days. The primary outcome was the incidence of major bleeding; secondary outcomes were clinically relevant non-major bleeding (CRNMB) and symptomatic VTE. RESULTS: We enrolled 206 patients with a mean age of 82 years, mean creatinine clearance of 33 mL min(-1) , and a mean Charlson co-morbidity index of 8.2. One patient had major bleeding (0.49%, 95% confidence interval [CI] 0.03-3.10), eight had CRNMB (3.88%, 95% CI 1.81-7.78) and three developed symptomatic VTE (1.46%, 0.38-4.55). Twenty-three patients (11.17%, 7.36-16.48) died. No independent predictors of bleeding were found at univariate analysis. CONCLUSIONS: The addition of moderate to severe renal impairment to patients with traditional risk factors for VTE identified a population of very elderly acutely ill medical patients potentially at high risk of both VTE and bleeding complications. The recently approved lower prophylactic dose of fondaparinux appears to be a safe and relatively effective strategy in these patients.
Asunto(s)
Anticoagulantes/administración & dosificación , Polisacáridos/administración & dosificación , Insuficiencia Renal/prevención & control , Tromboembolia Venosa/prevención & control , Anciano , Anciano de 80 o más Años , Creatinina/orina , Femenino , Fondaparinux , Hemorragia/etiología , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Embolia Pulmonar/complicaciones , Embolia Pulmonar/prevención & control , Insuficiencia Renal/complicaciones , Factores de Riesgo , Resultado del Tratamiento , Tromboembolia Venosa/complicaciones , Trombosis de la Vena/complicaciones , Trombosis de la Vena/prevención & controlAsunto(s)
Neoplasias/sangre , Neoplasias/complicaciones , Tromboembolia Venosa/complicaciones , Tromboembolia Venosa/diagnóstico , Anciano , Anticoagulantes/farmacología , Femenino , Fibrinolíticos/farmacología , Humanos , Masculino , Persona de Mediana Edad , Neoplasias/terapia , Pronóstico , Arteria Pulmonar/patología , Estudios Retrospectivos , Tomografía Computarizada por Rayos X/métodos , Resultado del TratamientoAsunto(s)
Diabetes Mellitus/fisiopatología , Alimentos , Insulina/metabolismo , Islotes Pancreáticos/metabolismo , Proinsulina/metabolismo , Anciano , Diabetes Mellitus/sangre , Diabetes Mellitus/metabolismo , Femenino , Humanos , Insulina/sangre , Secreción de Insulina , Masculino , Proinsulina/sangreRESUMEN
Eighteen patients affected with biopsy-proved primary biliary cirrhosis (PBC) (histological stage III and IV) received ursodeoxicholic acid (UDCA) 600 mg for 1 year. Signs and symptoms and biochemical tests (glutamic and oxalcetic transaminase, glutamic and pyruvic transaminase, bilirubine, gamma-glutamyl transpeptidase, alkaline phosphatase, leucine aminopeptidase, bile acids, plasma proteins electrophoresis, immunoglubulins A, G and M) and antimitochondrial antibodies were evaluated before the treatment and every four months during the treatment. The results were compared with those obtained in 8 untreated patients affected PBC. The control group of patients were comparable (as far as age, histological stage, biochemical tests are concerned) to the group who received UDCA. Bilirubine, ALP, gamma-GT and LAP decreased during the treatment with UDCA and remained lower than baseline values until the end of the observation (12 months), while no changes occurred in the untreated patients. Both in the treated and untreated group plasma protein electrophoresis, serum immunoglubulins A, G and M remained unchanged, as well as anti-mitochondrial antibody. A moderate reduction of transaminases and bile acids was observed in the group of patients receiving UDCA but it did not reach statistical significance. In 16 out of the 18 treated patients pruritus disappeared and resulted diminished in the remaining 2 patients. No significant amelioration of pruritus was observed in the patients who did not receive UDCA. In conclusion, our data show that prolonged treatment with UDCA drastically reduces pruritus and improves cholestasis biochemical tests in patients affected with symptomatic PBC.(ABSTRACT TRUNCATED AT 250 WORDS)