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AIDS ; 7(6): 841-7, 1993 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-8103342

RESUMEN

OBJECTIVE: To evaluate the serological and epidemiological characteristics of HTLV-I/II-positive blood donors in continental France during the first 6 months of universal screening of blood donations (n = 1,816,927). METHOD: A collaborative investigation of all confirmed anti-HTLV-I/II-positive samples reported by blood transfusion centres was performed. Seventy-three out of 77 reported samples were retested at two reference laboratories. Epidemiological data on risk factors were compiled. RESULTS: Of the 73 retested samples, 66 were confirmed to be HTLV-I-positive and one to be HTLV-II-positive; six samples were designated false-positive, mainly because of non-specific reactivity to recombinant gp21 in Western blot. The overall prevalence of HTLV-I/II in continental France is 0.039 per thousand. The main risk factor identified for HTLV-I infection was directly (origin) or indirectly (heterosexual contact) linked to endemicity in the Caribbean. The cost per case of avoided contamination in the 6-month period of this study was 1.36 million French francs. CONCLUSIONS: Sixty-two per cent of HTLV-I/II-infected blood donations would not have been discarded through the previous targeted HTLV screening or through other mandatory tests, including anti-hepatitis B core. To avoid false-positive results, we propose a new algorithm of diagnosis.


Asunto(s)
Donantes de Sangre , Anticuerpos Antideltaretrovirus/sangre , Infecciones por HTLV-I/epidemiología , Infecciones por HTLV-II/epidemiología , Tamizaje Masivo , Adulto , Western Blotting , ADN Viral/sangre , Ensayo de Inmunoadsorción Enzimática , Reacciones Falso Positivas , Femenino , Francia/epidemiología , Infecciones por HTLV-I/sangre , Infecciones por HTLV-I/prevención & control , Infecciones por HTLV-II/sangre , Infecciones por HTLV-II/prevención & control , Virus Linfotrópico T Tipo 1 Humano/inmunología , Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación , Virus Linfotrópico T Tipo 2 Humano/inmunología , Virus Linfotrópico T Tipo 2 Humano/aislamiento & purificación , Humanos , Masculino , Tamizaje Masivo/economía , Reacción en Cadena de la Polimerasa , Prevalencia , Provirus/aislamiento & purificación , Ensayo de Radioinmunoprecipitación , Factores de Riesgo , Encuestas y Cuestionarios , Viremia/microbiología , Indias Occidentales/etnología
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