Enhancing End-of-Life Care With Home-Based Palliative Interventions: A Systematic Review.

CONTEXT: Home-Based Palliative Care (HPC) interventions have emerged as a promising approach to deliver patient-centered care in familiar surroundings, aligning with patients' preferences and improving quality of life (QOL). OBJECTIVES: This review aimed to systematically assess the impact of HPC interventions on symptom management, QOL, healthcare resource utilization and place of death among patients with severe, progressive illnesses requiring end-of-life care. METHODS: A comprehensive search was conducted across PubMed, Cochrane, and Scopus databases to identify relevant studies published between January 1, 2013, and December 31, 2023. Eligible studies included randomized controlled trials and clinical studies evaluating the effectiveness of HPC interventions compared to usual care. Risk of bias assessment was performed using Cochrane tools. RESULTS: Nine publications meeting inclusion criteria were identified. Findings indicate that HPC interventions, delivered by specialized teams or integrated care approaches, significantly improve QOL and increase the likelihood of patients dying at home. Moreover, HPC is associated with reduced healthcare utilization, including fewer hospital admissions, emergency department visits, and shorter hospital stays. No significant differences were observed in symptom management. CONCLUSION: HPC interventions demonstrate significant benefits in addressing the complex needs of patients with advanced illnesses. These findings underscore the importance of integrating HPC into healthcare systems to optimize outcomes and promote quality end-of-life care. Future research should focus on expanding access to HPC services, enhancing interdisciplinary collaboration, and incorporating patient preferences to further improve care delivery in this vulnerable population.

Optimizing breathlessness management in amyotrophic lateral sclerosis: insights from a comprehensive systematic review.

BACKGROUND: Breathlessness is a prevalent symptom affecting the quality of life (QOL) of Amyotrophic Lateral Sclerosis (ALS) patients. This systematic review explored the interventions for controlling breathlessness in ALS patients, emphasizing palliative care (PALC), non-invasive ventilation (NIV), opioids, and non-pharmacological strategies. METHODS: A comprehensive search of PubMed, Cochrane Library, and Web of Science databases was conducted. Eligibility criteria encompassed adults with ALS or motor neuron disease experiencing breathlessness. Outcomes included QOL and symptom control. Study designs comprised qualitative studies, cohort studies, and randomized controlled trials. RESULTS: Eight studies were included, most exhibiting low bias risk, comprising one randomized controlled trial, three cohort studies, two comparative retrospective studies, and two qualitative studies (interviews). Most studies originated from Europe, with one from the United States of America. The participants totaled 3423, with ALS patients constituting 95.6%. PALC consultations significantly improved symptom assessment, advance care planning, and discussions about goals of care. NIV demonstrated efficacy in managing breathlessness, with considerations for device limitations. Opioids were effective, though predominantly studied in non-ALS patients. Non-pharmacological strategies varied in efficacy among patients. CONCLUSION: The findings underscore the need for individualized approaches in managing breathlessness in ALS. PALC, NIV, opioids, and non-pharmacological strategies each play a role, with unique considerations. Further research, especially ALS-specific self-management studies, is warranted.

Bedside preoperative predictors of difficult laryngeal exposure in microlaryngeal surgery.

PURPOSE: Successful microlaryngeal surgery relies on an adequate laryngeal exposure. Recognizing the likelihood of challenging exposure prior to microlaryngeal surgery may assist in selecting the appropriate surgical approach and even prompt consideration of alternative treatment options. We aim to apply the mini-Laryngoscore, a preoperative assessment tool, to our study population and incorporate novel variables to optimize the prediction model. METHODS: This single-center prospective cohort study included 80 consecutive patients undergoing elective microlaryngeal surgery, from January 1, to June 30, 2023. Each patient underwent a presurgical evaluation of 15 parameters and an intraoperative scoring of the anterior commissure visualization. These parameters were assessed for their association with difficult laryngeal exposure, using multiple logistic regression analysis. We created a novel prediction model for DLE and compared it with the existing model, the mini-Laryngoscore. RESULTS: Out of 80 patients, 24 (30%) patients had difficult laryngeal exposure, including 3 cases (3.8%) in which visualization of the anterior commissure was not possible. A large neck diameter (OR, 1.4; CI 1.1-1.9) and the presence of upper teeth (OR, 8.9; CI 1.3-62.8) were independent risk factors for a difficult laryngeal exposure, while a larger interincisors gap was the only independent protector factor (OR, 0.3; CI 0.1-0.8). The logistic regression model combining these three independent risk factors displayed a high discriminative value AUC = 0.89 (CI 0.81-0.97). The predictive performance of the mini-Laryngoscore was 0.73 (CI 0.62-0.85). CONCLUSION: Combining two parameters from the mini-Laryngoscore (upper jaw dental state and interincisors gap distance) with neck circumference measurement can accurately predict the risk of difficult laryngeal exposure.

Novel Epigenetic Modifiers of Histones Presenting Potent Inhibitory Effects on Adenoid Cystic Carcinoma Stemness and Invasive Properties.

Adenoid cystic carcinoma (ACC) is a rare neoplasm known for its indolent clinical course, risk of perineural invasion, and late onset of distant metastasis. Due to the scarcity of samples and the tumor's rarity, progress in developing effective treatments has been historically limited. To tackle this issue, a high-throughput screening of epigenetic drugs was conducted to identify compounds capable of disrupting the invasive properties of the tumor and its cancer stem cells (CSCs). ACC cells were screened for changes in tumor viability, chromatin decondensation, Snail inhibition along tumor migration, and disruption of cancer stem cells. Seven compounds showed potential clinical interest, and further validation showed that Scriptaid emerged as a promising candidate for treating ACC invasion. Scriptaid demonstrated a favorable cellular toxicity index, effectively inhibited Snail expression, induced hyperacetylation of histone, reduced cell migration, and effectively disrupted tumorspheres. Additionally, LMK235 displayed encouraging results in four out of five validation assays, further highlighting its potential in combating tumor invasion in ACC. By targeting the invasive properties of the tumor and CSCs, Scriptaid and LMK235 hold promise as potential treatments for ACC, with the potential to improve patient outcomes and pave the way for further research in this critical area.

Bilateral lipomatous hamartoma of the tongue: A case report in a child with oral-facial-digital syndrome type VI.

A hamartoma is a benign proliferation of typical mature cells specific to a particular anatomical site. In the oral cavity, they may occur as isolated cases or be associated with genetic syndromes. Oral-facial-digital syndrome type VI is a rare genetic disorder with an estimated incidence of one in 50,000-250,000 newborns. Here, we report a case of a 2-year-old boy diagnosed with oral-facial-digital syndrome type VI who was referred for evaluation of a bilateral and normochromic to slightly pinkish nodule on the lateral surface of the tongue. Clinically, the child presented hypotonia, low visual acuity, absence of oculocephalic reflex, delay in neuropsychomotor development, and polydactyly in the feet. Excisional biopsies of both sides of the tongue were performed using a 1.5 W high-power diode laser (wavelength of 980 nm), and histopathological analysis revealed abundant mature adipocytes predominantly arranged in lobules that mainly surrounded the minor salivary gland parenchyma. The surgical sites healed with no complications and the patient remains under follow-up for 10 months. Due to the limited literature on this syndrome and the frequent presence of tongue hamartomas in children, dentists need to be familiar with them.

Mindfulness on Symptom Control and Quality of Life in Patients in Palliative Care: A Systematic Review.

INTRODUCTION: Palliative care is a medical and humanitarian approach that improves the quality of life of patients, and their families, who are facing problems associated with chronic and life-threatening illnesses. Few studies have evaluated the effectiveness of mindfulness-based interventions for terminally ill or incurable patients. The aim of this study was to systematically review the literature on the effect of mindfulness-based interventions on symptom control and quality of life in patients in palliative care. METHODS: PubMed, Web of Science and Cochrane databases were searched for articles, published between January 2017 and December 2022, in English, including randomized controlled and clinical trials. Participants: terminally ill or incurable patients. Interventions: any mindfulness-based intervention. Comparators: any. Outcomes: symptom control and quality of life. The risk of bias was analysed through Cochrane's ROB-2 tool. RESULTS: Eight studies were included involving 609 patients and 75 dyads patients-spousal caregivers. The overall risk of bias was low to moderate. Mindfulness-based interventions are helpful in managing suffering, anxiety and depressive symptoms, fatigue, insomnia, drowsiness, appetite, and spiritual well-being. CONCLUSION: Mindfulness-based interventions control several symptoms and improve spiritual quality of life in patients in palliative care. Additionally, their informal caregivers also benefit from these interventions. Future trials are crucial to investigate other effects of mindfulness-based interventions, and their long-term benefits, in patients in palliative care.

Necrosis of the Tongue as a Late Complication of Radiotherapy.

Introduction: Irradiation to treat head and neck cancer, causing chronic tissue damage, is associated with the development of vascular disease. Interest has risen over the effects of radiotherapy on major vessels, due to its high morbidity and mortality rate. However, small-vessel disease has been poorly studied and described. Case Report: We present a case of a patient with bilateral necrosis of the anterior third of the tongue, occurring 3 years after chemoradiotherapy treatment for squamous cell carcinoma of the floor of the mouth. Contrast-enhanced CT scan showed multiple areas of stenosis concerning both external carotid arteries and their branches, and total opacification of lingual arteries. Conservative management was performed, with auto-amputation on the fifth day, which allowed healing by secondary intention. Conclusions: Necrosis of the tongue appears as a rare late complication of radiotherapy, possibly due to its acceleration effect on the atherosclerosis process. Following small-vessel disease, one can assume a higher potential risk of major-vessel disease, highlighting the importance of a routine assessment and prophylaxis of thrombotic events.

Palliative Extubation in Pediatric Patients in the Intensive Care Unit and at Home: A Scoping Review.

Aim: This scoping review is aimed at systematically mapping the evidence on palliative extubation in the pediatric intensive care unit. Methods: MEDLINE, EBSCO, and Cochrane databases were searched for articles published between January 2018 and December 2022, in English. Critical appraisal of sources of evidence was done using the Joanna Briggs Institute tools. PRISMA guidelines for scoping reviews were followed. Results: Six studies were included, with 366 patients, from the USA (n = 4), Brazil (n = 1), and Germany (n = 1). Three were high-quality studies, two were moderate, and one was a low-quality study. Most studies were retrospective analysis; two were narrative approaches; two were evidence-based recommendation and quality improvement project; one study was a prospective intervention. Conclusion: Symptom control is crucial pre- and postextubation. A checklist (symptom management and family support) and a postdebriefing template improve team communication and staff support postextubation. Critical care transports from the hospital are feasible to provide extubation at home. A framework addressing common planning challenges and resource management is recommended for extubation at home. The provision of pediatric palliative extubation is necessary since futile measures and prolongation of suffering violate the principle of nonmaleficence. Future research on this subject will result in more benefits for patients, parents, and professionals.

Palliative care interventions in chronic respiratory diseases: A systematic review.

INTRODUCTION: Chronic respiratory diseases represent a significant burden of disease globally, with high morbidity and mortality. Individuals living with these conditions, as well as their families, face considerable physical, emotional and social challenges. Palliative care might be a valuable approach to address their complex needs, but evidence to prove this is still scarce. OBJECTIVES: This systematic review aimed to study the effectiveness of palliative care interventions in health-related outcomes (quality of life, symptom control, symptom burden, psychological well-being, advance care planning, use of health services, and survival) in chronic respiratory patients. METHODS: Pubmed, Cochrane and Web of Science were searched for trials published in the last 10 years, comparing palliative care interventions to usual care, in patients with chronic respiratory diseases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. RESULTS: Eight studies were included, seven randomized controlled trials and one cluster-controlled trial; the former with moderate risk of bias and the latter with high risk of bias. Findings revealed that palliative interventions improve breathlessness control and advance care planning. There were no significant differences for the other outcomes. CONCLUSIONS: Palliative care appears to have a beneficial effect on breathlessness, one of the most distressing symptoms in patients suffering from chronic respiratory diseases and allows for advanced care planning. Additional research, with more robust trials, is needed to draw further conclusions about other health-related outcomes.

Effects of cannabinoids on pain control, quality of life and opioid-sparing in cancer patients: systematic review / Utilização de canabinoides no controle da dor, na qualidade de vida e no efeito poupador de opioides em pacientes com câncer: revisão sistemática

ABSTRACT BACKGROUND AND OBJECTIVES: Cannabinoids, such as delta-9-tetrahydrocannabinol and cannabidiol, have several therapeutic properties that may be useful in medicine. The objective of this study was to analyze the impact of cannabinoid use on pain control, quality of life and opioid-sparing in patients with advanced cancer. CONTENTS: A systematic review of the evidence for the use of cannabinoids in patients with advanced cancer was conducted on 1) Pain control; 2) Quality of life; and 3) Opioid-sparing effect. PubMed, Web of Science and Cochrane databases were searched for articles, written in English, published between January 1, 2011, and December 31, 2022, with the filters "randomized controlled trials" and "clinical trials". Using oral formulations of cannabinoids was accepted as "intervention" and placebo as "control". Risk of bias analysis was performed with Cochrane's RoB 2 and ROBINS-I tools. This review followed the 2020 PRISMA- statement. Ten studies were included, with 1169 participants, most with moderate risk of bias. The studies were from Australia (n=4), Canada (n=1), Israel (n=1), Mexico (n=1), The United Kingdom (n=1); two were multinationals. Eight were randomized, placebo-controlled trials; two were non-randomized studies. The most used formulation was nabiximols oral spray. Cannabinoids provide a clinical improvement in pain control. Evidence of improved quality of life with cannabinoids is inconclusive. Cannabinoids do not affect the daily dose of opioids in refractory cancer pain. Cannabinoid use cannot be said to have an opioid-sparing effect. CONCLUSION: It is necessary to expand research on the prescription of cannabinoids in individuals with cancer and other progressive diseases, with several comorbidities and multiple medications, in different health contexts.

RESUMO JUSTIFICATIVA E OBJETIVOS: Os canabinoides, como o delta-9-tetrahidrocanabinol e o canabidiol, possuem propriedades terapêuticas que podem ser úteis em pacientes oncológicos. O objetivo deste estudo foi avaliar o impacto do uso de canabinoides no controle da dor, na melhoria da qualidade de vida, e no efeito poupador de opioides em pacientes com câncer avançado. CONTEÚDO: Realizou-se uma revisão sistemática sobre a evidência da utilização de canabinoides em pacientes com câncer avançado, relativamente a: 1) Controle da dor; 2) Qualidade de vida; e 3) Efeito poupador de opioides. Foram buscados artigos na Pubmed, Web of Science e Cochrane, em inglês, publicados entre 2011 e 2022, com os filtros "randomized controlled trials" e "clinical trials". Aceitaram-se como "intervenção" qualquer uso de formulações orais de canabinoides e como "controle" o uso de placebo. Fez-se análise de viés com as ferramentas da Cochrane RoB 2 e ROBINS-I. Seguiu-se a Declaração PRISMA 2020. Foram incluídos 10 estudos, com 1169 participantes, a maioria com risco moderado de viés. Os estudos provinham de Austrália (n=4), Canadá (n=1), Israel (n=1), México (n=1), Reino Unido (n=1); dois eram multinacionais. Oito eram ensaios randomizados controlados com placebo; dois eram não randomizados. A formulação mais usada foi spray bucal de nabiximóis. Os canabinoides proporcionam uma melhoria clínica do controle da dor. A evidência da melhoria da qualidade de vida com canabinoides é inconclusiva. Os canabinoides não afetam a dose diária de opioides na dor oncológica refratária. Não se pode afirmar que o uso de canabinoides tem um efeito poupador de opioides. CONCLUSÃO: É necessário incrementar a investigação sobre a prescrição de canabinoides em indivíduos com câncer e outras doenças progressivas, com comorbilidades e polimedicação, em diferentes contextos de saúde.

Factors That Influence the Prescription of Antibiotic Therapy at the End-of-Life: Construction and Validation of a Scale.

INTRODUCTION: End-of-life care is frequently discussed in clinical practice. Non-beneficial treatments and the need for decision-making regarding therapeutic institutions are increasingly addressed. There are no guidelines regarding prescribing or de-prescribing antibiotic therapy at the end of life, which depends on clinical decisions. In this study, we developed a scale to assess the factors influencing clinicians' decisions when prescribing antimicrobial agents. METHODS: This is a quantitative, exploratory, and descriptive study. After the literature review, the scale was constructed with an analysis of internal consistency and temporal stability. It was applied online together with a sociodemographic and clinical questionnaire. Statistical analysis of the scale, its construction, and final validation were performed. RESULTS: A total of 196 physicians participated in this study (76.5% female, 78.6% aged <40 years), 60.2% specialists, and 35.7% without palliative care training. Almost all of the participants (89.9%) reported having end-of-life care concerns with a high frequency. In this study, a scale was developed to assess factors associated with the prescription of antibiotic therapy in end-of-life patients. This scale revealed the presence of 3 factors: infection, patient/illness, and symptoms. Together, the three factors explain 57.4% of the clinician's decisions. The factors associated with symptoms were the most predominant in decision-making compared to those associated with infection. CONCLUSIONS: Among the multiple factors that may influence the institution of antibiotic therapy at the end of life, symptomatic control is the most important factor.

Impact of the COVID-19 pandemic on the non-cancer chronic pain and its management in the elderly / Impacto da pandemia do COVID-19 na dor crônica não oncológica e sua gestão em pessoas idosas

ABSTRACT BACKGROUND AND OBJECTIVES: Chronic non-cancer pain is considered a public health problem, affecting 37% of the Portuguese population. Pain treatment represents a fundamental human right. However, during the COVID-19 pandemic, the vast majority of these patient care services were considered non-urgent or non-emergent, and clinical appointments and treatment were postponed or un-scheduled. Imposed restrictions, such as measures to prevent a COVID-19 infection, became counterproductive with regard to the management of chronic pain. Its impact should be emphasized especially in the older population, due to the associated physical and psychological comorbidities. This study aimed to analyze the impact of the COVID-19 pandemic on the pain of older people in four aspects: i) intensity, treatment and management of pain; ii) mental health; iii) lifestyles; iv) quality of life. METHODS: Review in Pubmed, SCOPUS and SCIELO databases using the terms: chronic non-cancer pain, pain management, aged and COVID-19. 86 articles were found and 13 were selected. Articles included cumulatively addressed chronic pain, represented original research of a clinical nature, and analyzed the impact of the COVID-19 pandemic on the management of chronic pain. Preference was given to studies with participants aged 65 years or older. Studies in adults with no mention of age in the context of the COVID-19 pandemic impact on aspects infuencing chronic pain and its management were also included. Only one article exclusively studied the senior population. RESULTS: The pandemic affected: i) increased pain intensity (n=10), changes in its pharmacological and non-pharmacological treatment (n=3) and its management, that is, the adaption of the health professionals and patients (n=1); ii) negatively affected mental health: symptoms of stress and anxiety/depression (n=9), psychological distress (n=4), social isolation/loneliness (n=6); iii) lifestyles: physical activity (n=4), sleep quality (n=4) and physical performance (n=5); iv) reduction of quality of life (n=5). Despite the heterogeneous results, a worsening of pain and mental health was found, as well as alteration of styles and quality of life and disruption of medical services. CONCLUSION: The restrictions imposed by the pandemic affected several areas of pain in the short term. Telemedicine has emerged as an adopted solution, but the barriers in the senior population, such as lack of digital literacy and lack of technological equipment, cannot be overlooked. The lack of knowledge of the specific impact of COVID-19 on the pain of the senior population calls for more research that focuses on the long-term consequences, as well as the solutions to be adopted in order to contain the damage in this vulnerable population. HIGHLIGHTS Worsening of pain and mental health, change in lifestyles and decreased quality of life. Disruption of medical services generated by the pandemic period reinforce the need for a holistic and individual approach to health care. Impact of the pandemic on chronic pain management has been little explored in older people. Need for further research focusing on long-term consequences, as well as the solutions to be adopted in order to contain injuries or dysfunctions in this vulnerable population.

RESUMO JUSTIFICATIVA E OBJETIVOS: A dor crônica não oncológica é considerada um problema de saúde pública, afetando 37% da população portuguesa. O tratamento da dor representa um direito humano fundamental. Entretanto, durante a pandemia do COVID-19, a grande maioria destes serviços de assistência ao paciente foi considerada como não urgente ou não emergente, sendo consultas e tratamentos clínicos adiados ou desmarcados. Restrições impostas, como medidas de prevenção da infecção por COVID-19, tornaram-se contraproducentes no que se refere à gestão da dor crônica. O seu impacto deve ser realçado principalmente na população mais idosa, devido às comorbidades associadas quer físicas quer psicológicas. O objetivo deste estudo foi analisar o impacto da pandemia do COVID-19 na dor de pessoas idosas em quatro aspectos: i) intensidade, tratamento e gestão da dor; ii) saúde mental; iii) estilo de vida; iv) qualidade de vida. MÉTODOS: Revisão nas bases de dados Pubmed, SCOPUS e Scielo usando os termos: chronic non-cancer pain, pain management, aged e COVID-19. Foram encontrados 86 artigos e selecionados 13. Foram incluídos artigos que cumulativamente versavam sobre dor crônica, representavam pesquisa original de natureza clínica e analisavam o impacto da pandemia do COVID-19 na gestão da dor crônica. A preferência foi dada a estudos com participantes com idade igual ou superior a 65 anos. Também foram analisados estudos realizados em adultos sem menção de idade no âmbito do impacto da pandemia do COVID-19 sobre os aspetos que infuenciam a dor crônica e a sua gestão. Apenas um artigo estudou exclusivamente a população idosa. RESULTADOS: A pandemia afetou: i) aumento da intensidade da dor (n=10), alterações no seu tratamento farmacológico e não farmacológico (n=3) e a sua gestão, isto é, a adaptação dos profissionais de saúde e dos doentes (n=1); ii) negativamente a saúde mental: sintomas de estresse e ansiedade/depressão (n=9), distresse psicológico (n=4), isolamento social/solidão (n=6); iii) estilos de vida: atividade física (n=4), qualidade do sono (n=4) e desempenho físico (n=5); iv) redução da qualidade de vida (n=5). Apesar dos resultados heterogêneos, verificou-se o agravamento da dor e saúde mental, alteração dos estilos e qualidade de vida, disrupção dos serviços médicos. CONCLUSÃO: As restrições impostas pela pandemia afetaram vários domínios da dor em curto prazo. A telemedicina surgiu como uma solução adotada, não podendo descurar os entraves na população idosa, como a falta de literacia digital e falta de equipamentos tecnológicos. O desconhecimento do impacto específico da COVID-19 na dor da população idosa sugere mais investigação que incida sobre as consequências em longo prazo, assim como as soluções a adotar de modo a conter lesões ou disfunções nesta população vulnerável. DESTAQUES Agravamento da dor e saúde mental, alteração dos estilos e diminuição da qualidade de vida. A disrupção dos serviços médicos gerados pelo período pandêmico reforça a necessidade de uma abordagem holística e individual na assistência de saúde. Impacto da pandemia na gestão da dor crônica foi pouco explorado em pessoas idosas. Necessidade de mais investigações que incidam sobre as consequências em longo prazo, assim como as soluções a adotar de modo a conter lesões ou disfunções nesta população vulnerável.

Disease-Specific Vs Non-Specific Questionnaires on Septoplasty Outcomes.

Introduction: Validated questionnaires are a valuable tool in medical practice. The role of septoplasty in improving patients' non-nasal symptoms and their quality of life is still controversial. The aim of this study was to determine the differences in outcome after septoplasty measured by a disease-specific questionnaire vs a general QoL questionnaire. Materials and Methods: A total of 50 patients underwent septoplasty and completed the SNOT-22 and the SF-36v2 questionnaires preoperatively and at 6 months post-op. Pre-op, post-op and variation for each domain in both questionnaires were calculated and compared with a measure of self-reported health transition (Question 2 of SF-36v2) and with the Minimal important difference (MID) for our sample. Results: SNOT-22 scores significantly improved for each specific question and for the total score. SF-36v2 showed a significant improvement in scores for mental domains (Mental Health, Role Emotional, and Vitality) but less so for the physical domains. MID for our sample was 4.2 points. Patients with variations greater than 4.2 in SNOT-22 total score (74%) revealed significantly better variations in Physical Function, General Health, Social Function and Vitality. Conclusions: Validated questionnaires are a fundamental tool for assessing outcomes of commonly performed surgeries in ENT. Disease-specific questionnaire showed improvement in scores for the majority of patients. The general QoL showed improvement only in Mental Domains. This may suggest that the impact of septoplasty in patient's general health might not be significant.

"You Don't Want Your Parents Knowing That You're Taking Pre-exposure Prophylaxis": Pre-exposure Prophylaxis Stigma Among Black and Latinx Adolescents.

ABSTRACT: Pre-exposure prophylaxis (PrEP) stigma is an understudied barrier to PrEP uptake among Black and Latinx adolescents. U.S. Black and Latinx adolescents (13-17 years) completed an online survey or participated in focus groups/interviews. Associations between PrEP stigma, PrEP disclosure, and provider-initiated PrEP discussion preferences were examined using logistic-regression models. Qualitative data provided further context to quantitative findings. The survey sample included 208 adolescents (53% female; 58% Latinx; M = 15 years), with 98% endorsing PrEP stigma. The qualitative sample included 26 adolescents (54% female; 34% Latinx; M = 15 years). PrEP stigma was associated with lower odds of PrEP disclosure to parents/guardians, and preference for health care providers to initiate PrEP-related discussions only with patients the provider judged to be at high risk for HIV. Qualitative data supported quantitative results: Adolescents endorsed multiple negative stereotypes about PrEP users. Mitigating PrEP stigma among Black and Latinx adolescents is an important step in overcoming challenges related to PrEP uptake.

Prescription trends at the end of life in a palliative care unit: observational study.

BACKGROUND: Symptomatic control is essential in palliative care, particularly in end-of-life, in which the pathophysiological changes that characterize this last phase of life strengthen the need to carry out an early therapeutic review. Hence, we aim to evaluate the prescribing pattern at a palliative care unit at two different time points: on admission and the day of the patient's death. METHODS: Quantitative, analytic, longitudinal, retrospective and observational study. Participants were adult patients who were admitted and died in a palliative care unit, in Portugal. Sociodemographic, clinical and pharmacological data were collected, including frequencies and routes of administration of schedule prescribed drugs and rescue drugs, from the day of admission until the day of death. RESULTS: 115 patients were included with an average age of 70.0 ± 12.9 years old, 53.9 were male, mostly referred by the Hospital Palliative Care Support Teams. The most common pathology was cancer, mainly in advanced stage. On admission, the median scheduled prescription was seven and "as needed" was three drugs. On the day of death, a decrease of prescriptions was observed. Opioids were always the most prescribed drugs. Near death, there was a higher tendency to prescribe butylscopolamine, midazolam, diazepam and levomepromazine. The most frequent route of drug administration was oral on admission and subcutaneous on the day of death. CONCLUSIONS: Polypharmacy is a reality in palliative care despite specialist palliative care teams. A reduction of prescribed drugs was verified, essentially due less comorbidity-oriented drugs. Further studies are required to analyse the importance of Hospital Palliative Care Support Teams.

Clinical and histopathological features of congenital epulis in a newborn submitted to laser surgery.

Congenital epulis (CE) is a rare condition in newborns, whose histogenesis remains unclear. It mostly presents as a circumscribed mass in the maxilla alveolar ridge of female neonates and can interfere with their normal breathing and breastfeeding. This benign oral lesion usually appears as a pedunculated nodule covered with normal mucosa that extends from the anterior vestibular alveolar ridge up to the posterior region. There are some pathological conditions that show clinical and histopathological features similar to those of CE, such as granular cell tumor, gingival cyst of the newborn, vascular malformations and others. This case report aimed to describe the clinical and pathological features of a newborn patient with a clinical and histopathological diagnosis of CE on the right side of the maxillary alveolar ridge, treated with excision by laser surgery, with a follow-up of 5 months without any sign of recurrence.

Palliative Care in Patients with Advanced Heart Failure: A Systematic Review.

INTRODUCTION: Heart failure is a disease with survival estimates of around 10% after 10 years of the disease. Being a chronic and debilitatingillness, it is important to investigate the potential efficacy of a palliative care approach for these patients. The aim of this study is to systematically review the efficacy of integrating palliative care in patients with advanced heart failure, including the outcomes overall quality of life and well-being, overall symptom burden and possible specific symptoms, hospital admission rates and mortality. MATERIAL AND METHODS: The MEDLINE, Cochrane, EMBASE and CINAHL databases were searched for articles published between January 2010 and December 2020 about palliative care interventions in patients with heart failure. Clinical studies with humans with symptomatic heart failure were included, comparing the integration of palliative care with usual cardiac care. RESULTS: The search protocol resulted in seven eligible studies for review and qualitative synthesis. The overall risk of bias within studies was moderate to high. Most studies demonstrated improvements with the integration of palliative care in terms of quality of life and reduction of admission rates. The evidence to support a significant improvement in overall symptom burden was not so robust among studies. CONCLUSION: Palliative care interventions seem, overall, to be significantly effective in patients with heart failure. Future studies with more rigorous study designs are needed, in order, to further develop the role of palliative care in heart failure patients.

Introdução: A insuficiência cardíaca apresenta estimativas de sobrevivência de cerca de 10% após 10 anos de doença. Tendo em conta que se trata de uma doença crónica debilitante, é importante investigar os potenciais benefícios e eficácia de uma abordagem de cuidados paliativos. Foi objectivo deste estudo rever de forma sistemática a eficácia dos cuidados paliativos destinados a doentes com insuficiência cardíaca avançada, em termos de qualidade de vida, controlo sintomático, admissões hospitalares e mortalidade. Material e Métodos: Pesquisa na base de dados MEDLINE, Cochrane, EMBASE e CINAHL por artigos publicados entre janeiro de 2010 a dezembro de 2020, tendo sido incluídos estudos clínicos em humanos com insuficiência cardíaca sintomática que compararam a integração de cuidados paliativos com a terapêutica padrão. Os outcomes selecionados para extração de dados foram a qualidade de vida, controlo sintomático, internamentos hospitalares e mortalidade. Resultados: O protocolo de pesquisa resultou em sete estudos elegíveis para revisão e análise qualitativa. O risco geral de viés foi considerado moderado a alto. A maioria dos estudos demonstrou uma melhoria com a integração de cuidados paliativos em termos de qualidade de vida e redução de hospitalizações. A evidência de suporte de uma melhoria significativa no controlo sintomático geral não foi tão robusta. Conclusão: Os cuidados paliativos aparentam ser, em geral, significativamente eficazes para doentes com insuficiência cardíaca avançada. É necessária investigação futura, com estudos mais rigorosos, para realçar o papel dos cuidados paliativos nos doentes com insuficiência cardíaca.