Asunto(s)
Consumo de Bebidas Alcohólicas/epidemiología , Alcoholismo/epidemiología , Infecciones por VIH/transmisión , Educación en Salud , Conducta Sexual , Estudiantes/estadística & datos numéricos , Adolescente , Adulto , Consumo de Bebidas Alcohólicas/efectos adversos , Condones/estadística & datos numéricos , Femenino , Infecciones por VIH/prevención & control , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Factores de RiesgoRESUMEN
Only two cases of Noonan Syndrome (NS) associated with tumor have previously been reported. The authors describe two new cases of NS with acute lymphoblastic leukemia (ALL), which were part of a series of 370 consecutive ALL untreated patients.
Asunto(s)
Síndrome de Noonan/complicaciones , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones , Preescolar , Femenino , Humanos , Lactante , MasculinoRESUMEN
Langerhans cell histiocytosis (LCH) is a non-malignant disorder, whether localized or disseminated, and usually has a favourable prognosis. A possible relationship between LCH and neoplastic diseases has not been assessed up to now even if a few cases have been recorded. We report two new cases of acute leukemia in children with LCH. The first child had acute lymphoblastic leukemia after untreated LCH; the second developed acute promyelocytic leukemia after LCH treated with vinblastine and etoposide. To our knowledge, this is the first case of secondary leukemia after exposure to an epipodophyllotoxin derivative in a child with benign disease. Cooperative studies of large numbers of LCH patients are needed to evaluate a possible association between LCH and acute leukemia, and to identify common risk factors or predisposing agents if such be present.