[The characteristics of the development of endogenous intoxication after chronic radiation exposure and thermal trauma]. / Osobennosti razvitiia éndogennoi intoksikatsii posle khronicheskogo luchevogo vozdeistviia i termicheskoi travmy.

Chronic whole-body gamma irradiation of rats at the cumulative doses of 0.25 or 1 Gy results in a significant increase in the bacterial toxemia. A thermal injury suffered 3 months after the irradiation aggravates the bacterial toxemia and increases a number of medium-mass molecules. A thermal injury alone causes less pronounced changes in the toxemia indices as compared to the above combined damage.

[The characteristics of the development of bacterial enterotoxemia and endotoxemia in combined radiation and thermal lesions]. / Osobennosti razvitiia bakterial'noi énteroéndotoksemii pri kombinirovannykh radiatsionno-termicheskikh porazheniiakh.

Thermal burn of irradiated rats increases the level and the length of the postirradiation enteroendotoxemia and aggravates the postirradiation impairment of the hematoenterocitic barrier. The pharmacological correction of the small intestine motility and introduction of ciproheptadine, an agent that blocks serotonin receptors, ameliorates the above phenomenon in radiation and thermal injuries.

[Decrease in bacterial toxemia after radiation-thermal injury in the restoration of motor-evacuation function of the gastrointestinal tract]. / Snizhenie bakterial'noi intoksikatsii posle radiatsionno-termicheskogo porazheniia pri vosstanovlenii motorno-évakuatornoi funktsii zheludochno-kishechnogo trakta.

Experiments were conducted on male Wistar rats to study the possibility of restoration of the motor-evacuative function (MEF) of the gastrointestinal tract (GIT) after radiothermal injury (irradiation with a dose of 6 Gr+Stage IIIb burn). Changes in the development of bacterial intoxication in the injured organism were analysed. Restoration of GIT MEF in the injured rats leads to simultaneous diminution of the degree of bacterial toxemia which plays an important role in the pathogenesis of radiothermic injury.

[Functional changes in the small intestine under the influence of sorbents in rats with a radiation-thermal lesion]. / Izmenenie funktsii tonkoi kishki pod vliianiem sorbentov u krys s radiatsionno-termicheskim porazheniem.

Major small intestine functions of rats were inhibited after whole-body exposure to radiation and heat. The injection of sorbents varying in the chemical structure favored the recovery of the small intestine function.

[Changes in the severity of burn shock in irradiated animals under the influence of blood serum alpha- and beta-globulins]. / Izmenenie tiazhesti ozhogovogo shoka u obluchennykh zhivotnykh pod vliianiem al'fa- i beta-globulinov syvorotki krovi.

Injection of blood serum alpha-beta-globulins during burn shock normalizes the amount of middle mass molecular peptides, acid proteinase activity, acid-base balance, and hemodynamics in irradiated rats. The survival of animals in this period increases from 23% to 52%.

[Changes in small intestine function after radiation and thermal injury]. / Izmenenie funktsii tonkoi kishki posle radiatsionno-termicheskogo porazheniia.

A study of the small intestine functions after radiation and thermal affection of rats has revealed an inhibited absorption of carbohydrates, fats and proteins. The disturbance of the resorption of these substances results from a change in the motor-evacuator function and a decrease in the activity of the appropriate enzymes in the small intestine mucosa.

[Enzymatic differentiation and absorptive capacity of the epithelium of small intestine macrocolonies]. / Fermentativnaia differentsirovka i vsasyvaiushchaia sposobnost' épiteliia makrokolonii tonkoi kishki.

Research into the activity of the enzymes invertase, gamma-amylase, alkaline phosphatase in the macrocolonies of the rat small intestine has shown that each macrocolony has stringently individual functional properties and the predominance of one of the enzymes. The data have been also obtained, indicating different rate of lysin and leucin absorption by the macrocolony epithelium of the small intestine. The results prove the existence of a definite functional differentiation of epitheliocytes (macrocolonies) arising from the same stem cell of the intestinal epithelium.

[Radioprotective effect of pyrazolone derivatives]. / Radiozashchitnyi éffekt nekotorykh proizvodnykh pirazolona

The intraperitoneal injection of analgin (1000 mg/kg), antipurine (400 mg/kg), amidopyrine (100 mg/kg) 3 hours before the irradiation of mice in a dose of 800 R led to survival of 30 to 45% of the animals (against 12.5% in control) and to increase in the average duration of life of the animals that perished. 80-95% of mice survived the period of "intestinal deaths" (the 7th day after the irradiation) after combined prophylactic use of purasolone derivatives and cystamine before the irradiation of these animals in a dose of 1050 R. The radioprotective effect of pyrasolone derivatives given in therapeutic doses was less pronounced.