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Kuznetsova, S A; Petrukov, K S; Pletnev, F I; Sergiev, P V; Dontsova, O A.

Biochemistry (Mosc) ; 84(8): 851-869, 2019 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-31522668

RESUMEN

The review summarizes the data on pro- and eukaryotic RNA (C5-cytosine) methyltransferases. The structure, intracellular location, RNA targets, and catalytic mechanisms of these enzymes, as well as the functional role of methylated cytosine residues in RNA are presented. The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention is given to the similarities and differences in the structures and mechanisms of action of RNA and DNA methyltransferases. The data on the association of mutations in the RNA (C5-cytosine) methyltransferases genes and human diseases are presented.

Asunto(s)

5-Metilcitosina/metabolismo , Metiltransferasas/química , Metiltransferasas/fisiología , Procesamiento Postranscripcional del ARN/fisiología , 5-Metilcitosina/química , Secuencia de Aminoácidos/genética , Animales , ADN (Citosina-5-)-Metiltransferasas/genética , ADN (Citosina-5-)-Metiltransferasas/fisiología , Humanos , Metilación , Metiltransferasas/genética , Ratones , Mutación , Filogenia , Estructura Secundaria de Proteína , ARN de Transferencia/genética , ARN de Transferencia/metabolismo , ARNt Metiltransferasas

RESUMEN

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