Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety.

OBJECTIVES: To determine the psychopathological profile of patients with central sensitization (CS) in a sample of knee osteoarthritis, with and without CS, and fibromyalgia, and to compare their psychopathological profiles. METHODS: The final sample consists of 19 patients with osteoarthritis and CS (mean 66.37 years ± 8.77), 41 osteoarthritis patients without CS (mean 66.8 ± 7.39 years), 47 fibromyalgia patients (mean 46.47 years ± 7.92) and 26 control subjects (mean 51.56 years ± 11.41). The psychopathological profile was evaluated with the Millon Multiaxial Clinical Inventory. RESULTS: The average score of MCMI-III reflect higher scores in the fibromyalgia and osteoarthritis-CS groups. Patients with osteoarthritis-CS are more likely to report larger scores in Borderline and Major Depression scales. Fibromyalgia patients are more likely to report more increased scores in Somatoform and Major Depression, versus osteoarthritis-CS group. Fibromyalgia patients versus osteoarthritis without CS are more likely to report higher scores in Schizoid, Depression, Histrionic, Sadistic, Borderline, Somatoform, Posttraumatic Stress Disorder and Major Depression scales. DISCUSSION: Patients with CS have less differences in their psychopathological profiles as well as in both osteoarthritis groups and greatest differences are obtained between the fibromyalgia and osteoarthritis without CS, so perhaps presence of CS is the key to differentiate those groups and not chronic pain. An exhaustive assessment brings more accurate psychopathological profiles, thus better psychological treatment could be applied.

Reactantes de fase aguda en la artropatía psoriásica. Sensibilidad en la valoración de la actividad inflamatoria y correlación con la actividad articular / Clinical usefulness of acute phase reactants in psoriatic arthritis

Objetivos: Demostrar y cuantificar la correlación entre los reactantes de fase aguda, velocidad de sedimentación globular y proteína C reactiva, y la actividad articular en la artropatía psoriásica. Material y métodos: Estudio transversal prospectivo de 60 pacientes afectados de artropatía psoriásica, todos con afección articular periférica, en los que se ha valorado la actividad de la enfermedad, analizando variables clínicas (número de articulaciones dolorosas y tumefactas) y analíticas (reactantes de fase aguda). Resultados: Se demuestra una baja correlación, aunque estadísticamente significativa (r > 0,5; p < 0,05), entre la actividad articular y los reactantes de fase aguda. La proteína C reactiva resulta más sensible que la velocidad de sedimentación globular en este sentido (AU)

Vértebra osteoblástica de etiología poco frecuente / Osteoblastic vertebra of infrequent etiology rheumatology

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