[Effect of colchamine on the rates of cell proliferation in animal tissues]. / Vliianie kolkhamina na tempy kletochnogo razmnozheniia v tkaniakh zhivotnykh.

A significant decrease in the rate of cell entering into mitosis was discovered in exocrine cells of the pancreas and in liver parenchymal cells of 7-day-old rats after colchamine injections at varying times of day. These data indicate that the colchamine method should not be applied to the assessment of mitosis duration and cell proliferation rates in animal tissues.

[Diurnal changes in the number of mitoses and cells synthesizing DNA in the tissues of young rats]. / Sutochnye izmeneniia chisla mitozov i kletok, sinteziruiushchikh DNK, v tkaniakh molodykh krys

Regular circadian variations in the mitotic index and in the number of cells synthesizing DNA (labelled nuclei index) were shown in the liver, epidermis, and in the exocrine portion of the pancreas in 7-day-old rats. The nature of these changes differed in the tissues under study. No regular correlations between the carcadian variations in these two indices were revealed.

[Diurnal changes in the duration of mitosis in rats]. / O sutochnykh izmeneniiakh dlitel'nosti mitoza u krys

The colchicine method was applied to the study of the 24-hour changes in the duration of mitosis in 45-day rats. The average diurnal duration of mitosis in the pancreatic epithelium, the liver and the epidermis of adult animals was almost half of that in the 7-day-old rats. Diurnal variations of the mitotic index in the investigated tissues could be due both to the variation in the mitotic rate and to that of the duration of mitosis.

[Diurnal changes in the duration of mitosis in several tissues of young white rats]. / Sutochnye izmeneniia prodolzhitel'nosti mitoza v nekotorykh tkaniakh molodykh belykh krys

In the acinar cells of the pancreas of 7-day rats the duration of mitosis varied from 1.7 to 2.5 hours, in the hepatocytes--from 1.3 to 5.2 and in the epidermis--from 1.5 to 2.9 hours. The 24-hour variations in the mitotic index were expressed both by the changes in the duration of mitosis and by unequal rate of the cell entrance into mitosis. The peroid of renewal of the tissues under study markedly differing in adult animals proved to be approximately the same in rats aged 7 days (12,3 days in the pancreas and 20 days in the liver and the epidermis).