RESUMEN
The IPEM has helped stakeholders in a very complex tertiary medical center to understand the importance of interactive planning. The need to do so was highlighted by nursing demand and shortage issues. Deliberate efforts to refine and to restructure patient care within a hospital necessitates multidisciplinary planning and problem solving, collaborative nurse/physician relationships, and sound recruitment/retention policies. The experience at one hospital shows how nurse executives can take ownership of issues that help to reduce nursing supply and demand problems. Restructuring of patient care is one method of addressing demand; supply can be addressed locally by collaborative relationships with schools of nursing to increase students' access to education. Enhancing professional nursing practice is the responsibility of nursing service executives as well as educators. Yet, ultimately, it is the hospital's professional environment and reward system that influences nurses' choice of practice setting.
Asunto(s)
Modelos Teóricos , Personal de Enfermería en Hospital/provisión & distribución , Técnicas de Planificación , Humanos , Enfermeras Administradoras , Admisión y Programación de Personal , Reorganización del Personal , Análisis de Sistemas , Estados UnidosRESUMEN
A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiosensitive. In part, the resistance of this T cell appears to relate to a reduced activity of a microsomal reductase responsible for converting mitomycin-C to its more active form. Discrepancies in reductase activity may represent a way to differentiate among subsets of lymphocytes.
Asunto(s)
Mitomicinas/farmacología , Linfocitos T/efectos de los fármacos , Animales , Composición de Base , Concanavalina A/farmacología , ADN/análisis , Relación Dosis-Respuesta a Droga , Resistencia a Medicamentos , Ganglios Linfáticos/metabolismo , Activación de Linfocitos/efectos de los fármacos , Ratones , Mitomicina , Mitomicinas/metabolismo , Oxidorreductasas/análisis , Bazo/metabolismoRESUMEN
In comparison with administration of mitomycin, lethal irradiation (2,000 rad) of the stimulator cells in a one-way mixed leukocyte culture results in a reduced response due at least in part to the release of inhibitory materials by the irradiated cells. These inhibitory molecules may be partially removed by washing and possess differential reactivity with respect to phytohemagglutinin, concanavalin A, lipopolysaccharide, and pokeweed mitogen.