The spectral profile of cortical activation during a visuospatial mental rotation task and its correlation with working memory.

Introduction: The search for a cortical signature of intelligent behavior has been a longtime motivation in Neuroscience. One noticeable characteristic of intelligence is its association with visuospatial skills. This has led to a steady focus on the functional and structural characteristics of the frontoparietal network (FPN) of areas involved with higher cognition and spatial behavior in humans, including the question of whether intelligence is correlated with larger or smaller activity in this important cortical circuit. This question has broad significance, including speculations about the evolution of human cognition. One way to indirectly measure cortical activity with millisecond precision is to evaluate the event-related spectral perturbation (ERSP) of alpha power (alpha ERSP) during cognitive tasks. Mental rotation, or the ability to transform a mental representation of an object to accurately predict how the object would look from a different angle, is an important feature of everyday activities and has been shown in previous work by our group to be positively correlated with intelligence. In the present work, we evaluate whether alpha ERSP recorded over the parietal, frontal, temporal, and occipital regions of adolescents performing easy and difficult trials of the Shepard-Metzler's mental rotation task, correlates or are predicted by intelligence measures of the Weschler's intelligence scale. Methods: We used a database obtained from a previous study of intellectually gifted (N = 15) and average intelligence (N = 15) adolescents. Results: Our findings suggest that in challenging task conditions, there is a notable difference in the prominence of alpha event-related spectral perturbation (ERSP) activity between various cortical regions. Specifically, we found that alpha ERSP in the parietal region was less prominent relative to those in the frontal, temporal and occipital regions. Working memory scores predict alpha ERSP values in the frontal and parietal regions. In the frontal cortex, alpha ERSP of difficult trials was negatively correlated with working memory scores. Discussion: Thus, our results suggest that even though the FPN is task-relevant during mental rotation tasks, only the frontal alpha ERSP is correlated with working memory score in mental rotation tasks.

The role of frontal and parietal cortex in the performance of gifted and average adolescents in a mental rotation task.

Visual-spatial abilities are usually neglected in academic settings, even though several studies have shown that their predictive power in science, technology, engineering, and mathematics domains exceeds that of math and verbal ability. This neglect means that many spatially talented youths are not identified and nurtured, at a great cost to society. In the present work, we aim to identify behavioral and electrophysiological markers associated with visual spatial-ability in intellectually gifted adolescents (N = 15) compared to age-matched controls (N = 15). The participants performed a classic three-dimensional mental rotation task developed by Shepard and Metzler (1971) [33] while event-related potentials were measured in both frontal and parietal regions of interest. While response time was similar in the two groups, gifted subjects performed the test with greater accuracy. There was no indication of interhemispheric asymmetry of ERPs over parietal regions in both groups, although interhemispheric differences were observed in the frontal lobes. Moreover, intelligence quotient and working memory measures predicted variance in ERP's amplitude in the right parietal and frontal hemispheres. We conclude that while gifted adolescents do not display a different pattern of electroencephalographic activity over the parietal cortex while performing the mental rotation task, their performance is correlated with the amplitude of ERPs in the frontal cortex during the execution of this task.

Health inequalities by region and social group based on data from household surveys (Brazil, 1998-2013). / Desigualdades regionais e sociais em saúde segundo inquéritos domiciliares (Brasil, 1998-2013).

This article discusses trends in health inequalities and access to health services across the regions of Brazil using data from household surveys conducted between 1998 and 2013. Social inequality was measured based on the ratio between the extremes of years of schooling considering two age groups (18 to 59 years and 60 years and over). The findings show a decline in health status and increase in prevalence of diabetes and hypertension in both age groups, which may be related to the expansion of primary healthcare. The findings regarding the percentage of people who had had a medical appointment in the last 12 months show that low levels of inequalities persist despite a general improvement in access. Despite an increase in the percentage of people with up to 3 years of schooling who had had a dental appointment in the last year, significant inequalities persist. The percentage of people who reported being admitted to hospital in the last 12 months was greater among people with up to 3 years of schooling throughout the study period. The hospitalization rate decreased in both age groups across almost all regions. The proportion of women aged between 50 and 69 years with up to 3 years of schooling who had had a mammogram increased, leading to a decrease in inequality. The findings show the need to ensure the continuity of household surveys to monitor inequalities in access to health care services by region and social group.

Este artigo busca discutir a evolução das desigualdades em saúde e no acesso aos serviços de saúde nas grandes regiões a partir de inquéritos domiciliares realizados de 1998 a 2013. As desigualdades sociais foram analisadas pelas razões de extremos de anos de escolaridade, considerando duas faixas etárias (18 a 59 anos e 60 anos ou mais). Nas condições de saúde, observa-se, nos dois grupos etários, uma pior avaliação do estado de saúde e um aumento da prevalência de diabetes e hipertensão, o que pode estar relacionado à expansão da atenção básica. Quanto à realização de consultas médicas no último ano, encontra-se, no geral, maior acesso, com manutenção de pequenas desigualdades. A maior utilização de consulta odontológica entre os de menor escolaridade provoca uma redução nas desigualdades, que ainda são significativas. As internações hospitalares, ao longo da série, são maiores entre os menos escolarizados, e há uma redução nas taxas nos dois grupos etários, em quase todas as regiões. Percebe-se um aumento na realização de mamografia por mulheres menos escolarizadas, com diminuição da desigualdade. Os resultados corroboram a necessidade da continuidade dos inquéritos domiciliares para o monitoramento das desigualdades regionais e sociais no acesso ao sistema de saúde.

Desigualdades regionais e sociais em saúde segundo inquéritos domiciliares (Brasil, 1998-2013) / Health inequalities by region and social group based on data from household surveys (Brazil, 1998-2013)

Resumo Este artigo busca discutir a evolução das desigualdades em saúde e no acesso aos serviços de saúde nas grandes regiões a partir de inquéritos domiciliares realizados de 1998 a 2013. As desigualdades sociais foram analisadas pelas razões de extremos de anos de escolaridade, considerando duas faixas etárias (18 a 59 anos e 60 anos ou mais). Nas condições de saúde, observa-se, nos dois grupos etários, uma pior avaliação do estado de saúde e um aumento da prevalência de diabetes e hipertensão, o que pode estar relacionado à expansão da atenção básica. Quanto à realização de consultas médicas no último ano, encontra-se, no geral, maior acesso, com manutenção de pequenas desigualdades. A maior utilização de consulta odontológica entre os de menor escolaridade provoca uma redução nas desigualdades, que ainda são significativas. As internações hospitalares, ao longo da série, são maiores entre os menos escolarizados, e há uma redução nas taxas nos dois grupos etários, em quase todas as regiões. Percebe-se um aumento na realização de mamografia por mulheres menos escolarizadas, com diminuição da desigualdade. Os resultados corroboram a necessidade da continuidade dos inquéritos domiciliares para o monitoramento das desigualdades regionais e sociais no acesso ao sistema de saúde.

Abstract This article discusses trends in health inequalities and access to health services across the regions of Brazil using data from household surveys conducted between 1998 and 2013. Social inequality was measured based on the ratio between the extremes of years of schooling considering two age groups (18 to 59 years and 60 years and over). The findings show a decline in health status and increase in prevalence of diabetes and hypertension in both age groups, which may be related to the expansion of primary healthcare. The findings regarding the percentage of people who had had a medical appointment in the last 12 months show that low levels of inequalities persist despite a general improvement in access. Despite an increase in the percentage of people with up to 3 years of schooling who had had a dental appointment in the last year, significant inequalities persist. The percentage of people who reported being admitted to hospital in the last 12 months was greater among people with up to 3 years of schooling throughout the study period. The hospitalization rate decreased in both age groups across almost all regions. The proportion of women aged between 50 and 69 years with up to 3 years of schooling who had had a mammogram increased, leading to a decrease in inequality. The findings show the need to ensure the continuity of household surveys to monitor inequalities in access to health care services by region and social group.

Computer-aided structure-based design of multitarget leads for Alzheimer's disease.

Alzheimer's disease is a neurodegenerative pathology with unmet clinical needs. A highly desirable approach to this syndrome would be to find a single lead that could bind to some or all of the selected biomolecules that participate in the amyloid cascade, the most accepted route for Alzheimer disease genesis. In order to circumvent the challenge posed by the sizable differences in the binding sites of the molecular targets, we propose a computer-assisted protocol based on a pharmacophore and a set of required interactions with the targets that allows for the automated screening of candidates. We used a combination of docking and molecular dynamics protocols in order to discard nonbinders, optimize the best candidates, and provide a rationale for their potential as inhibitors. To provide a proof of concept, we proceeded to screen the literature and databases, a task that allowed us to identify a set of carbazole-containing compounds that initially showed affinity only for the cholinergic targets in our experimental assays. Two cycles of design based on our protocol led to a new set of analogues that were synthesized and assayed. The assay results revealed that the designed inhibitors had improved affinities for BACE-1 by more than 3 orders of magnitude and also displayed amyloid aggregation inhibition and affinity for AChE and BuChE, a result that led us to a group of multitarget amyloid cascade inhibitors that also could have a positive effect at the cholinergic level.

[Regional differences in access to coronary bypass surgery in Brazil, 2002-2010]. / Diferenças regionais no acesso a cirurgia cardiovascular no Brasil, 2002-2010.

The hospitalization rates for angioplasty and coronary bypass surgery have been used as proxies for access to highly specialized services. The scope of this study is to analyze the evolution of these rates and discuss what are the possible causes associated with regional inequalities. Standardized rates of angioplasty and coronary bypass surgery by age and sex per 100,000 inhabitants aged 20 and over, in the period from 2002 to 2010 were calculated. Comparison with international data shows that Brazil has lower rates than those observed in OECD countries. In Brazil, the standardized rates of hospitalization for angioplasty in the population aged 20 and over showed an upward trend, rising from 27.5 per 100,000 in 2002 to 39 in 2010. When mortality rates by age and sex from different geographical regions were compared, besides the marked differences in the north - south axis, what is notable is the maintenance of a stable pattern of these rates and regional differences over the period analyzed. The definition of regional health care networks for cardiac surgery is an important strategy to ensure the quality of care, optimization of operating costs and reduction of inequalities in access to healthcare between Brazilian regions.

Diferenças regionais no acesso a cirurgia cardiovascular no Brasil, 2002 -2010 / Regional differences in access to coronary bypass surgery in Brazil, 2002-2010

As taxas internação por angioplastia e cirurgia de revascularização vêm sendo usadas como proxies de acesso a serviços de alta complexidade. O objetivo é analisar sua evolução e discutir quais seriam as possíveis causas associadas às desigualdades regionais. Foram calculadas as taxas padronizadas de realização de angioplastia e cirurgia de revascularização por sexo e idade por 100 mil habitantes de 20 anos e mais, no período 2002 a 2010. A comparação com os dados internacionais mostra que o Brasil tem taxas menores que as observadas nos países da OECD. No Brasil, as taxas padronizadas de internação por angioplastia na população de 20 anos ou mais apresentaram uma tendência de crescimento, passando de 27,5 por 100 mil habitantes em 2002 para 39 por 100 mil em 2010. Na comparação das taxas padronizadas por idade e sexo entre as grandes regiões do Brasil, além das diferenças marcantes no eixo Norte - Sul, o que chama atenção é que mantenham um padrão estável e também as diferenças regionais. A constituição de redes assistenciais regionais hierarquizadas para cirurgias cardíacas constitui uma estratégia importante para: garantir a qualidade do cuidado, a optimização dos custos operacionais e reduzir as desigualdades no acesso entre as regiões brasileiras.

The hospitalization rates for angioplasty and coronary bypass surgery have been used as proxies for access to highly specialized services. The scope of this study is to analyze the evolution of these rates and discuss what are the possible causes associated with regional inequalities. Standardized rates of angioplasty and coronary bypass surgery by age and sex per 100,000 inhabitants aged 20 and over, in the period from 2002 to 2010 were calculated. Comparison with international data shows that Brazil has lower rates than those observed in OECD countries. In Brazil, the standardized rates of hospitalization for angioplasty in the population aged 20 and over showed an upward trend, rising from 27.5 per 100,000 in 2002 to 39 in 2010. When mortality rates by age and sex from different geographical regions were compared, besides the marked differences in the north - south axis, what is notable is the maintenance of a stable pattern of these rates and regional differences over the period analyzed. The definition of regional health care networks for cardiac surgery is an important strategy to ensure the quality of care, optimization of operating costs and reduction of inequalities in access to healthcare between Brazilian regions.

[Evaluation of performance of health systems: a model for analysis]. / Avaliação de Desempenho de Sistemas de Saúde: um modelo de análise.

This paper presents a review of the Dimension Matrix for Evaluation of the Brazilian Health System that was initially developed in 2003, as well as a conceptual update of some of the sub-dimensions for the evaluation of health service performance, namely effectiveness, access, efficiency and appropriateness of health care. It also describes the indicator selection process as well as the results obtained in each performance dimension. The behavior of the indicators used to assess the performance of health services in Brazil, with respect to each sub-dimension, was not uniform. Areas of marked improvement were found in indicators that are influenced by activities in the field of primary care. The most significant improvements were seen in the sub-dimensions of Effectiveness and Access. With respect to the Efficiency of health services, situations of high efficiency coexist with others with substandard performance. The performance of health services in the sub-dimension of Appropriateness of Health Care was the lowest of all indicators.

Avaliação de Desempenho de Sistemas de Saúde: um modelo de análise / Evaluation of performance of health systems: a model for analysis

Este artigo apresenta uma revisão da Matriz de Dimensões da Avaliação do Sistema de Saúde no Brasil desenvolvida em 2003, e uma atualização conceitual de parte das subdimensões de avaliação do desempenho dos serviços de saúde: efetividade, acesso, eficiência e adequação. Descreve o processo de seleção dos indicadores utilizados e uma síntese dos resultados para cada subdimensão do desempenho. O comportamento dos indicadores utilizados para avaliar o desempenho dos serviços de saúde no Brasil, no que se refere às quatro subdimensões selecionadas, não é uniforme e as melhorias mais acentuadas são observadas naquelas influenciadas pela atuação dos serviços no campo da atenção primária, as melhorias mais significativas foram observadas nas Efetividade e Acesso. Em relação à Eficiência dos serviços de saúde coexistem situações de alta eficiência com outras de baixo desempenho. A atuação dos serviços de saúde na subdimensão Adequação foi pior do que nas demais apresentadas.

This paper presents a review of the Dimension Matrix for Evaluation of the Brazilian Health System that was initially developed in 2003, as well as a conceptual update of some of the sub-dimensions for the evaluation of health service performance, namely effectiveness, access, efficiency and appropriateness of health care. It also describes the indicator selection process as well as the results obtained in each performance dimension. The behavior of the indicators used to assess the performance of health services in Brazil, with respect to each sub-dimension, was not uniform. Areas of marked improvement were found in indicators that are influenced by activities in the field of primary care. The most significant improvements were seen in the sub-dimensions of Effectiveness and Access. With respect to the Efficiency of health services, situations of high efficiency coexist with others with substandard performance. The performance of health services in the sub-dimension of Appropriateness of Health Care was the lowest of all indicators.

[An analysis of use of the health services by financing system: Brazil 1998-2008]. / Uma analise da utilização de serviços de saúde por sistema de financiamento: Brasil 1998 -2008.

This article analyzes the use of health services from the perspective of financing based on PNAD/IBGE micro-data related to 1998, 2003 and 2008. Among the main results, the following can be highlighted: 1) The Unified Health System (SUS) continues to be the major financing agent of most consultations and hospitalizations in Brazil; its participation increased significantly between 1998 and 2003 and remained almost stable between 2003 and 2008; 2) SUS participation in financing the use of the health services has been predominant in all Brazilian regions, especially in the North and North-East, which feature the most precarious socio-economic and health conditions; 3) SUS is the major financing agent of the two extreme levels of complexity of health care: primary care and high complexity services. 4) In spite of a significant rise in utilization rates of SUS services for consultations and hospitalizations, great inequities can still be observed between the population that exclusively uses SUS and that which has private health insurance; 5) There has been an increase in the use of SUS health services by part of the population with private health insurance plans.

Uma analise da utilização de serviços de saúde por sistema de financiamento: Brasil 1998 -2008 / An analysis of use of the health services by financing system: Brazil 1998-2008

Este artigo analisa, a partir de microdados de 1998, 2003 e 2008 da PNAD/IBGE, a utilização de serviços de saúde sob a perspectiva de seu financiamento Entre os principais resultados da análise, destacam-se os seguintes: 1) o SUS continua financiando a maioria dos atendimentos e das internações realizados no País, participação que aumentou significativamente entre 1998 e 2003, mantendo-se praticamente estável entre 2003 e 2008; 2) a participação do SUS no financiamento da utilização dos serviços de saúde foi preponderante em todas as regiões, sendo maior nas regiões Norte e Nordeste com situações sanitárias e sócio-econômicas mais precárias; 3) o SUS é o principal financiador dos dois níveis extremos de complexidade da atenção à saúde: o de atenção básica e o da alta complexidade; 4) apesar do aumento verificado nas taxas de utilização do SUS, para atendimentos e internações, ainda persistem grandes inequidades no uso de serviços de saúde entre a população atendida pelo SUS e a população beneficiaria de planos e seguros de saúde privados; 5) foi observado um aumento na utilização de serviços do SUS por parte dessa população com asseguramento privado.

This article analyzes the use of health services from the perspective of financing based on PNAD/IBGE micro-data related to 1998, 2003 and 2008. Among the main results, the following can be highlighted: 1) The Unified Health System (SUS) continues to be the major financing agent of most consultations and hospitalizations in Brazil; its participation increased significantly between 1998 and 2003 and remained almost stable between 2003 and 2008; 2) SUS participation in financing the use of the health services has been predominant in all Brazilian regions, especially in the North and North-East, which feature the most precarious socio-economic and health conditions; 3) SUS is the major financing agent of the two extreme levels of complexity of health care: primary care and high complexity services. 4) In spite of a significant rise in utilization rates of SUS services for consultations and hospitalizations, great inequities can still be observed between the population that exclusively uses SUS and that which has private health insurance; 5) There has been an increase in the use of SUS health services by part of the population with private health insurance plans.

[Communicative approach of Situational Strategic Planning at the local level: health and equity in Venezuela]. / Enfoque comunicativo del Planeamiento Estratégico Situacional en el nivel local: salud y equidad en Venezuela.

The article discusses the results of operationalizing Situational Strategic Planning adapted to the local level in health, considering the communicative approach and equity in a parish in Venezuela. Two innovative criteria were used: estimated health needs and analysis of the actors' potential for participation. The problems identified were compared to the corresponding article on rights in the Venezuelan Constitution. The study measured inequalities using health indicators associated with the selected problems; equity criteria were incorporated into the action proposals and communicative elements. Priority was assigned to the problem of "low case-resolving capacity in the health services network", and five critical points were selected for the action plan, which finally consisted of 6 operations and 21 actions. The article concludes that the combination of epidemiology and planning expands the situational explanation. Incorporation of the communicative approach and the equity dimension into Situational Strategic Planning allows empowering health management and helps decrease the gaps from inequality.

Enfoque comunicativo del Planeamiento Estratégico Situacional en el nivel local: salud y equidad en Venezuela / Communicative approach of Situational Strategic Planning at the local level: health and equity in Venezuela

El artículo discute los resultados de la operacionalización del Planeamiento Estratégico Situacional (PES) adaptado al nivel local en salud, considerando el enfoque comunicativo y la dimensión de la equidad en una parroquia en Venezuela. Se utilizaron dos criterios innovadores: la estimativa de las necesidades de salud y el análisis del potencial participativo de los actores. Los problemas identificados fueron relacionados con los artículos referentes a derechos de la Constitución venezolana. Se midieron inequidades con indicadores de salud, asociados al problema seleccionado; se incorporaron criterios de equidad en las propuestas de acción y elementos comunicativos. Se dio prioridad al problema "baja capacidad resolutiva de la red de servicios de salud" y se seleccionaron cinco nudos críticos para el plan de acción, que quedó constituido por 6 operaciones y 21 acciones. Se concluyó que la articulación de la epidemiología y planeamiento amplía la explicación situacional. La incorporación del enfoque comunicativo y de la dimensión de equidad al PES permite potencializar la gestión en salud y contribuir a la disminución de las brechas por inequidad.

The article discusses the results of operationalizing Situational Strategic Planning adapted to the local level in health, considering the communicative approach and equity in a parish in Venezuela. Two innovative criteria were used: estimated health needs and analysis of the actors' potential for participation. The problems identified were compared to the corresponding article on rights in the Venezuelan Constitution. The study measured inequalities using health indicators associated with the selected problems; equity criteria were incorporated into the action proposals and communicative elements. Priority was assigned to the problem of "low case-resolving capacity in the health services network", and five critical points were selected for the action plan, which finally consisted of 6 operations and 21 actions. The article concludes that the combination of epidemiology and planning expands the situational explanation. Incorporation of the communicative approach and the equity dimension into Situational Strategic Planning allows empowering health management and helps decrease the gaps from inequality.

O mix público-privado no Sistema de Saúde Brasileiro: financiamento, oferta e utilização de serviços de saúde / The public-private mix in the Brazilian Health System: financing, delivery and utilization of health services

O artigo analisa o mix público-privado do sistema de saúde brasileiro a partir da oferta, utilização e financiamento dos serviços de saúde. Contempla os subsídios públicos para o setor privado. Trata-se de um estudo quantitativo, baseado em dados secundários provenientes de bases de dados oficiais. Mostra que existem desigualdades na oferta e na utilização de serviços em prol da população com plano de saúde, em decorrência da peculiar inserção do setor suplementar, que oferece cobertura suplementar e duplicada ao sistema público (SUS), sem desconsiderar que outros fatores podem determinar o uso de serviços de saúde e aumentar as desigualdades. A análise é feita com base na tipologia de mix público-privado desenvolvida pela OECD em 2004, que auxilia a compreensão das desigualdades que ocorrem em cada tipo de mix, e mostra que as que ocorrem no sistema de saúde brasileiro se dão pelo fato de a cobertura de serviços ofertados pelo segmento de seguro privado ser duplicada à cobertura de serviços do SUS. Ainda, as desigualdades verificadas no sistema de saúde brasileiro ocorrem num sistema de saúde em que o financiamento público ao SUS é minoritário e existem grandes subsídios públicos para o setor privado.

This paper analyzes the public-private mix in the Brazilian Health System from the perspective of health care delivery, utilization and financing. Moreover, this quantitative study based on secondary data from official databases contemplates the subsidies granted by the government to the private sector. It shows the existence of some inequalities favoring the population having private health plans, a result of the peculiar participation of the private sector in the Brazilian Health System not only offering supplementary care but duplicating the coverage offered by the public system (called SUS). The analysis is made on the basis of the classification of public-private mix in Health Systems developed by the OECD in 2004, that helps understanding the kinds of inequalities occurring in each type of public-private mix. The inequalities that occur in the Brazilian system must be understood as the result of the duplicated coverage offered by the private market and of the weak public funding for the SUS while granting important subsidies to the private sector.

[The public-private mix in the Brazilian Health System: financing, delivery and utilization of health services]. / O mix público-privado no Sistema de Saúde Brasileiro: financiamento, oferta e utilização de serviços de saúde.

This paper analyzes the public-private mix in the Brazilian Health System from the perspective of health care delivery, utilization and financing. Moreover, this quantitative study based on secondary data from official databases contemplates the subsidies granted by the government to the private sector. It shows the existence of some inequalities favoring the population having private health plans, a result of the peculiar participation of the private sector in the Brazilian Health System not only offering supplementary care but duplicating the coverage offered by the public system (called SUS). The analysis is made on the basis of the classification of public-private mix in Health Systems developed by the OECD in 2004, that helps understanding the kinds of inequalities occurring in each type of public-private mix. The inequalities that occur in the Brazilian system must be understood as the result of the duplicated coverage offered by the private market and of the weak public funding for the SUS while granting important subsidies to the private sector.