Modulatory influence of rarely repeated of immobilization episodes on the interleukin-1ß-dependent reaction of blood leukocytes and hepatoprotective effect of restraint stress.

Repeated episodes of 1-h restraint stress were accompanied by a decrease in the sensitivity of blood leukocytes and cytochrome P450-dependent monooxygenases of the liver to recombinant IL-1ß. These changes are associated with the anti-inflammatory hepatoprotective effect of chronic stress.