Evidence of insufficient genetic data and lack of regular genetic research on rabies virus in the Russian Federation: a study of the recent epizootic situation.

This paper attempts to point out a disparity between keeping rabies epidemiological statistics and rabies virus sequencing in the Russian Federation. While data on rabies prevention and laboratory detection are duly gathered, virus sequencing efforts remain insufficient. Along with a lack of public information and mass vaccination campaigns for wildlife and pets, this also might have an impact on the current rabies situation, which is of high risk in Russia. Additionally, drawing on GenBank data, it is suggested that some isolated rabies variants might be circulating in the country.

In Vivo Studies of a Liquid Embolic Compound.

A composition in the form of liquid polymer substance intended for embolization procedures was studied in in vivo experiment. The preparation was injected to rabbits into the femoral artery and abdominal aorta. The polymer composition exhibited properties previously demonstrated in vitro: strong adhesion to the vascular wall, high plasticity sufficient for embolization of the blood vessels, distal distribution, and the absence of toxic effects. The contrast substance remained in the embolus, which simplified its further localization. The agent underwent nether resorption nor organization. Injection of the agent in a volume of 0.1 ml was sufficient for embolization of an artery with a diameter of 0.1 cm. The polymer composition completely obstructed the vessel without inducing perforation of its wall. During the first day of the experiment, a slight infiltration of surrounding tissues with lymphoid cells was observed. By day 7, total dry necrosis of pelvic limb distal to the injection site was diagnosed. Inflammation of the surrounding tissues was shown histologically and was considered as the body response to impaired circulation and necrosis.