[Effect of ammonium succinate on pharmacological effects of acetylsalicylic acid]. / Vliianie ammoniia suktsinata na farmacologicheskie éffekty kisloty atsetilsalitsilovoi.

Ammonia succinate potentiates the main pharmacological properties and reduces the toxic effects (ulcerogenic action and general toxicity) of acetylsalicylic acid. The new preparation astam, representing a combination of acetylsalicylic acid with ammonia succinate in a 2:1 ratio, is proposed. Astam exhibits antiexudative, capillary-reinforcing, antiproliferative, pain-relieving, antipyretic, antiaggregant, and antioxidant properties. In addition, the drug inhibits the development of structural-metabolic disorders in the case of chronic immune inflammation of joints and various internal organs.

[The therapeutic and prophylactic effect of 4-iodoantipyrine in experimental tick-borne encephalitis]. / Lechebnyi i profilakticheskii éffekt 4-iodantipirana pri éksperimental'nom kleshchevom éntsefalite.

The antiviral activity of iodantipyrine-4 belonging to the group of nonsteroid anti-inflammatory compounds was studied in inbred white mice of 10-12 g given a single subcutaneous injection of the Absettarov strain of tick-borne encephalitis virus. Iodantipyrine-4 in different doses was administered orally or parenterally, and the animals were observed for 21 days. In the group of mice infected with 10 LD50 of TBE virus which were treated with the drug orally in a dose of 50 mg/kg a reliable therapeutic effect was established in 60%, after parenteral injection in 53.4%. Prophylactic administration of the drug followed by challenge with 10 LD50 of virus was effective in 47% of mice. In the group of mice infected with 100 LD50 of the virus the therapeutic effect was observed in 38% and prophylactic in 30%. Iodantipyrine-4 was found to induce interferon production.

[Immunomodulating properties of non-steroidal anti-inflammatory drugs]. / Immunomoduliruiushchie svoistva nesteroidnykh protivovospalitel'- nykh sredstv.

There has been studied the influence of a number of nonsteroidal antiinflammatory agents (NSAID ) on the humoral immune response of mice in immunization with erythrocytic and viral antigen. It has been found out that NSAID have immunomodulating effect, stimulating humoral immune response (4-iodantipyrine, 4-bromantipyrine) or suppressing it (butadione, sodium salicylate). Apparently the mechanism of NSAID ++ immunostimulating effect is related to the inhibition of T-suppressors ++ function by the latter ones.

[Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment]. / Povyshenie izbiratel'nosti deistviia tsitostatikov tsiklofosfana i 5-ftoruratsila s pomoshch'iu ékstrakta shlemnika baikal'skogo v éksperimente.

In experiments with murine and rat transplantable tumors, Scutellaria baicalensis Georgii extract treatment was shown to ameliorate cyclophosphamide and 5-fluorouracil-induced myelotoxicity and to decrease tumor cell viability. This was partly attributed to a pronounced antistressor action of the extract and its normalizing effect on some homeostatic parameters.

[Antiviral inhibitor induction under the influence of some anti-inflammatory agents]. / Induktsiia antivirusnykh ingibitorov pod vliianiem nekotorykh protivovospalitel'nykh sredtsv

An investigation into the effect produced by a series of acyl-derivatives of pyrasolone and salicytates on the generation of antiviral inhibitors (AVI) to the RNA and DNA-carrying viruses in the tissue cultures and chick embryos ascertained the active AVI inhibitors to be derivatives of 4-amino- and 4-methylaminoantipyrine, acylated with higher fatty and substituted benzoic acids.