RESUMEN
This prospective study evaluated the prognostic value of early neurobiochemical markers, neuron-specific enolase and astroglial protein S-100B, for long-term cognitive outcome after cardiac arrest. Six months after admission of a cohort of 80 consecutive patients, 26 survivors were able to undergo a neuropsychological test battery. Survivors showed low test performances in attention, learning/memory, and executive functioning. Neuropsychological bedside screening during the first month significantly differentiated between patients with and without long-term cognitive impairment. The neurobiochemical marker S-100B at day 3 after admission was found to predict significant proportions of variance in specific cognitive domains (learning/memory and executive functioning). The results indicate that early neuropsychological assessment might help identify patients who run at risk of long-term neuropsychological dysfunction. This study also suggests that especially the protein S-100B provides valuable information on long-term cognitive outcomes. To understand the exact relationship, results have to be replicated in larger trials.
Asunto(s)
Trastornos del Conocimiento/diagnóstico , Trastornos del Conocimiento/etiología , Paro Cardíaco/complicaciones , Adulto , Anciano , Análisis de Varianza , Atención/fisiología , Trastornos del Conocimiento/metabolismo , Estudios de Cohortes , Femenino , Paro Cardíaco/metabolismo , Humanos , Aprendizaje/fisiología , Masculino , Escala del Estado Mental , Persona de Mediana Edad , Destreza Motora/fisiología , Factores de Crecimiento Nervioso/sangre , Pruebas Neuropsicológicas , Fosfopiruvato Hidratasa/sangre , Valor Predictivo de las Pruebas , Solución de Problemas/fisiología , Curva ROC , Análisis de Regresión , Estudios Retrospectivos , Subunidad beta de la Proteína de Unión al Calcio S100 , Proteínas S100/sangre , Factores de Tiempo , Percepción Visual/fisiologíaRESUMEN
OBJECTIVE: To determine the prognostic accuracy of biochemical, clinical, electrophysiological, and neuropsychological investigations in predicting outcomes after cardiac arrest. DESIGN: Prospective study. SETTING: Intensive care unit of the Hamburg-Eppendorf University Medical Center, Hamburg, Germany. PATIENTS: A total of 80 patients (mean age, 63.79 +/- 15.85 yrs) after cardiopulmonary resuscitation. INTERVENTIONS: Serial blood samples (days 2-4), clinical examinations (days 2 and 4), sensory-evoked potentials (day 4), and neuropsychological assessments (Asunto(s)
Reanimación Cardiopulmonar
, Potenciales Evocados Somatosensoriales
, Paro Cardíaco/terapia
, Factores de Crecimiento Nervioso/sangre
, Pruebas Neuropsicológicas
, Fosfopiruvato Hidratasa/sangre
, Proteínas S100/sangre
, Adolescente
, Adulto
, Anciano
, Anciano de 80 o más Años
, Biomarcadores/sangre
, Coma
, Femenino
, Paro Cardíaco/sangre
, Paro Cardíaco/fisiopatología
, Humanos
, Modelos Logísticos
, Masculino
, Persona de Mediana Edad
, Análisis Multivariante
, Pronóstico
, Modelos de Riesgos Proporcionales
, Estudios Prospectivos
, Curva ROC
, Subunidad beta de la Proteína de Unión al Calcio S100
, Sensibilidad y Especificidad
, Resultado del Tratamiento